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Q87M23

- TYPH_VIBPA

UniProt

Q87M23 - TYPH_VIBPA

Protein

Thymidine phosphorylase

Gene

deoA

Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.UniRule annotation

    Catalytic activityi

    Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. phosphorylase activity Source: InterPro
    2. pyrimidine-nucleoside phosphorylase activity Source: InterPro
    3. thymidine phosphorylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pyrimidine nucleobase metabolic process Source: InterPro
    2. pyrimidine nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciVPAR223926:GHK4-2492-MONOMER.
    UniPathwayiUPA00578; UER00638.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine phosphorylaseUniRule annotation (EC:2.4.2.4UniRule annotation)
    Alternative name(s):
    TdRPaseUniRule annotation
    Gene namesi
    Name:deoAUniRule annotation
    Ordered Locus Names:VP2435
    OrganismiVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
    Taxonomic identifieri223926 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000002493: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 442442Thymidine phosphorylasePRO_0000059072Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi223926.VP2435.

    Structurei

    3D structure databases

    ProteinModelPortaliQ87M23.
    SMRiQ87M23. Positions 1-437.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0213.
    HOGENOMiHOG000047313.
    KOiK00758.
    OMAiFINGVRD.
    OrthoDBiEOG61ZTGG.

    Family and domain databases

    Gene3Di3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPiMF_01628. Thymid_phosp.
    InterProiIPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR018090. Pyrmidine_PPas_bac/euk.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR013465. Thymidine_Pase.
    [Graphical view]
    PANTHERiPTHR10515. PTHR10515. 1 hit.
    PfamiPF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000478. TP_PyNP. 1 hit.
    SMARTiSM00941. PYNP_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsiTIGR02643. T_phosphoryl. 1 hit.
    TIGR02644. Y_phosphoryl. 1 hit.
    PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q87M23-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYLPQEIIRK KRDGEVLTAD EINFFIQGVA NNTVSEGQIA AFAMTIFFNE    50
    MTMDERIALT CAMRDSGMVI DWSHMNFGGP IVDKHSTGGV GDVTSLMLGP 100
    MVAACGGFVP MISGRGLGHT GGTLDKLEAI PGYNITPTNE VFGQVTKDAG 150
    VAIIGQTGDL APADKRVYAT RDITATVDNI SLITASILSK KLAAGLESLV 200
    MDVKVGSGAF MPTYEASEEL AKSIVAVANG AGTKTTAILT DMNQVLASSA 250
    GNAVEVREAV RFLTGEYRNP RLLEVTMASC AEMLVLAKLA ENTDDARAKL 300
    MEVLDNGKAA ACFGKMVAGL GGPADFVENY DNYLEKAEII KPVYATETGI 350
    VSAMDTRAIG MAVVSMGGGR RVATDEIDYA VGFDNFIRLG EVADSDKPLA 400
    VIHARSEGQW EEAAKALRSA IKVGGEYTPT PEVYRQIRAE DI 442
    Length:442
    Mass (Da):46,963
    Last modified:June 1, 2003 - v1
    Checksum:iCBFA67F6BE75341D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000031 Genomic DNA. Translation: BAC60698.1.
    RefSeqiNP_798814.1. NC_004603.1.

    Genome annotation databases

    EnsemblBacteriaiBAC60698; BAC60698; BAC60698.
    GeneIDi1189948.
    KEGGivpa:VP2435.
    PATRICi20143014. VBIVibPar50997_2336.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000031 Genomic DNA. Translation: BAC60698.1 .
    RefSeqi NP_798814.1. NC_004603.1.

    3D structure databases

    ProteinModelPortali Q87M23.
    SMRi Q87M23. Positions 1-437.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 223926.VP2435.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC60698 ; BAC60698 ; BAC60698 .
    GeneIDi 1189948.
    KEGGi vpa:VP2435.
    PATRICi 20143014. VBIVibPar50997_2336.

    Phylogenomic databases

    eggNOGi COG0213.
    HOGENOMi HOG000047313.
    KOi K00758.
    OMAi FINGVRD.
    OrthoDBi EOG61ZTGG.

    Enzyme and pathway databases

    UniPathwayi UPA00578 ; UER00638 .
    BioCyci VPAR223926:GHK4-2492-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPi MF_01628. Thymid_phosp.
    InterProi IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR018090. Pyrmidine_PPas_bac/euk.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR013465. Thymidine_Pase.
    [Graphical view ]
    PANTHERi PTHR10515. PTHR10515. 1 hit.
    Pfami PF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000478. TP_PyNP. 1 hit.
    SMARTi SM00941. PYNP_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsi TIGR02643. T_phosphoryl. 1 hit.
    TIGR02644. Y_phosphoryl. 1 hit.
    PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
      Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
      Lancet 361:743-749(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RIMD 2210633.

    Entry informationi

    Entry nameiTYPH_VIBPA
    AccessioniPrimary (citable) accession number: Q87M23
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3