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Protein

Glutaminase

Gene

glsA

Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei64 – 641SubstrateUniRule annotation
Binding sitei115 – 1151SubstrateUniRule annotation
Binding sitei159 – 1591SubstrateUniRule annotation
Binding sitei166 – 1661SubstrateUniRule annotation
Binding sitei190 – 1901SubstrateUniRule annotation
Binding sitei242 – 2421SubstrateUniRule annotation
Binding sitei260 – 2601Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciVPAR223926:GHK4-2691-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GlutaminaseUniRule annotation (EC:3.5.1.2UniRule annotation)
Gene namesi
Name:glsAUniRule annotation
Ordered Locus Names:VP2623
OrganismiVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Taxonomic identifieri223926 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002493 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306GlutaminasePRO_0000110630Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi223926.VP2623.

Structurei

3D structure databases

ProteinModelPortaliQ87LI9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiVNSIMAT.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q87LI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPTAEILTD ILAEVRPLIG QGKVADYIPA LAKVPNNKLA IAVYTNEGEV
60 70 80 90 100
IKAGDADESF SIQSISKALS LTLAMCLYKQ EEIWARVGKE PSGQAFNSLI
110 120 130 140 150
QLEMEQGIPR NPFINAGAIV VADLLQSRLS APRQRLLEFV RQLSGDTHIV
160 170 180 190 200
YDKVVAASEM MHGDRNAAIA YLMRSFGNFE NEVIPVLQNY FHACALKMSC
210 220 230 240 250
VDLAKTFSYL ANKGTSVQTG KPVVSPTQTK QLNALLATCG LYDGAGEFAY
260 270 280 290 300
RVGMPGKSGV GGGIIAVVPG EMTIAVWSPE LDASGNSLAG TKALELLSER

IGRSIF
Length:306
Mass (Da):32,854
Last modified:June 16, 2003 - v1
Checksum:i80120402FF68CC18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000031 Genomic DNA. Translation: BAC60886.1.
RefSeqiNP_799002.1. NC_004603.1.
WP_005482494.1. NC_004603.1.

Genome annotation databases

EnsemblBacteriaiBAC60886; BAC60886; BAC60886.
GeneIDi1190147.
KEGGivpa:VP2623.
PATRICi20143402. VBIVibPar50997_2519.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000031 Genomic DNA. Translation: BAC60886.1.
RefSeqiNP_799002.1. NC_004603.1.
WP_005482494.1. NC_004603.1.

3D structure databases

ProteinModelPortaliQ87LI9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi223926.VP2623.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC60886; BAC60886; BAC60886.
GeneIDi1190147.
KEGGivpa:VP2623.
PATRICi20143402. VBIVibPar50997_2519.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiVNSIMAT.
OrthoDBiEOG6N94BK.

Enzyme and pathway databases

BioCyciVPAR223926:GHK4-2691-MONOMER.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
    Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
    Lancet 361:743-749(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RIMD 2210633.

Entry informationi

Entry nameiGLSA_VIBPA
AccessioniPrimary (citable) accession number: Q87LI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 16, 2003
Last modified: May 27, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.