Reviewed, UniProtKB/Swiss-Prot Q87KN5 (STHA_VIBPA)

Names and origin

Protein names

Recommended name:
    Soluble pyridine nucleotide transhydrogenase
      Short name=STH
    EC=1.6.1.1
Alternative name(s):
    NAD(P)(+) transhydrogenase [B-specific]

Gene names

Name:	sthA
Ordered Locus Names:	VP2942

Organism

Vibrio parahaemolyticus [Complete proteome] [HAMAP]

Taxonomic identifier

670 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	466 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation By similarity.
Catalytic activity	NADPH + NAD(+) = NADP(+) + NADH.
Cofactor	Binds 1 FAD per subunit By similarity.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	FAD Flavoprotein NAD NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NADP metabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	NAD(P)+ transhydrogenase (B-specific) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 466	466	Soluble pyridine nucleotide transhydrogenase		PRO_0000068076
Regions
	Nucleotide binding	36 – 45	10	FAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q87KN5-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: F05180E3BFA56C4D	FASTA	466	51,349
	10 20 30 40 50 60 MAHVNHYDVI VIGSGPGGEG AAMGLTKAGL NVAIVEKESS VGGGCTHWGT IPSKALRHAV 70 80 90 100 110 120 SRIIEFNSNP LFCRNNTSLH ATFSDILGHA KTVIDKQTRL RQGFYDRNDC TLLFGTARFI 130 140 150 160 170 180 DTHSIAVMQN DGTEETYSAD KFVIATGSRP YRPSDVDFLH ERIYDSDSIL SLKHDPRHII 190 200 210 220 230 240 IYGAGVIGCE YASIFRGLGV KTDLINTRDR LLEFLDNEVS DALSYHFWNS GVVIRNDETY 250 260 270 280 290 300 EKIEGTEDGV IIHLQSGKKM RADCLLYANG RTGNTDKLSL DVVGLESDSR GQLKVNRNYQ 310 320 330 340 350 360 TAVEHIYAVG DVIGYPSLAS AAYDQGRFVA QAITKGQAEN YLIEDIPTGI YTIPEISSVG 370 380 390 400 410 420 KTEQELTAAK VPYEVGRSSF KHLARAQIAG KDVGSLKILF HRETKEILGI HCFGERAAEI 430 440 450 460 IHIGQAIMEQ KGQANTIEYF VNTTFNYPTM AEAYRVAALN GLNRLF

References

[1]

"Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae." Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T. Lancet 361:743-749(2003) [PubMed: 12620739] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RIMD 2210633 / Serotype O3:K6.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000031 Genomic DNA. Translation: BAC61205.1.
RefSeq	NP_799321.1.
3D structure databases
HSSP	HSSP built from PDB template 1LPF based on UniProtKB P14218.
ModBase	Search...
Genome annotation databases
GeneID	1190528.
GenomeReviews	Gene locus VP2942 in contig BA000031_GR.
KEGG	vpa:VP2942.
NMPDR	fig|223926.1.peg.2942.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q87KN5.
Enzyme and pathway databases
BioCyc	VPAR223926:VP2942-MON.
Family and domain databases
HAMAP	MF_00247. [Tree]
InterPro	IPR000759. Adrndx_reductase. IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR000815. Hg_reductase. IPR001100. Pyr_nuc-diS_OxRdtase. IPR004099. Pyr_nucl-diS_OxRdtase_dimer. IPR001327. Pyr_OxRdtase_NAD_bd. [Graphical view]
Gene3D	G3DSA:3.30.390.30. Pyr_redox_dim. 1 hit.
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. PF02852. Pyr_redox_dim. 1 hit. [Graphical view]
PRINTS	PR00419. ADXRDTASE. PR00368. FADPNR. PR00945. HGRDTASE. PR00411. PNDRDTASEI.
ProDom	PD000139. FAD_pyr_redox. 1 hit. [Graphical view] [Entries sharing at least one domain]
BLOCKS	Search...
ProtoNet	Search...

Entry information

Entry name

STHA_VIBPA

Accession

Primary (citable) accession number: Q87KN5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2003
Last sequence update:	June 1, 2003
Last modified:	November 4, 2008
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)