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Q87KH4 (GPPA_VIBPA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

EC=3.6.1.40
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene names
Name:gppA
Ordered Locus Names:VP3003
OrganismVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) [Complete proteome] [HAMAP]
Taxonomic identifier223926 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity. HAMAP-Rule MF_01550

Catalytic activity

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate. HAMAP-Rule MF_01550

Pathway

Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2. HAMAP-Rule MF_01550

Sequence similarities

Belongs to the GppA/Ppx family. GppA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 497497Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase HAMAP-Rule MF_01550
PRO_0000194294

Sequences

Sequence LengthMass (Da)Tools
Q87KH4 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 28977E25011DD2CB

FASTA49754,689
        10         20         30         40         50         60 
MSQAGSSPLY AAIDLGSNSF HMLVVRHIDG SVQTMAKIKR KVRLAAGLDE HNSLSMEAMQ 

        70         80         90        100        110        120 
RGWDCLSLFA ERLQDIPTQN IRIVGTATLR TATNVDVFLE KANQILGQPI EVISGEEEAA 

       130        140        150        160        170        180 
TIYKGVAHTS GGSGRRLVVD IGGASTELII GEGFEAKALT SLKMGCVTWL ENFFKDRQLN 

       190        200        210        220        230        240 
ARNFEAAIEG AKQTIKPILE QYTDLGWDVC VGASGTVQAL QEIMLAQGMD EVITHSKLKR 

       250        260        270        280        290        300 
LQKQAMLADH LEELDIEGLT LERALVFPSG LSILIAIFEL LEIDAMTLAG GALREGLVYE 

       310        320        330        340        350        360 
MVDELRQNDI RARTICSVQS RYQLDCQYGE QVATLAGKLL EQAGGDEWIA EPQGKVLLET 

       370        380        390        400        410        420 
TAKLHEIGLT IDFKKGGEHS AYLLQNLDLP GYTRAQKFFI GEIARRYREQ LSSLPEQHAI 

       430        440        450        460        470        480 
SGTSAKRVLR LLRLAVLLTH RRNPSLEPQV ELLAEGDKLT LSIDAKWLEA NPLTAAELEI 

       490 
ESNRQTDIGW PLTITAC 

« Hide

References

[1]"Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
Lancet 361:743-749(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RIMD 2210633.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000031 Genomic DNA. Translation: BAC61266.1.
RefSeqNP_799382.1. NC_004603.1.

3D structure databases

ProteinModelPortalQ87KH4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING223926.VP3003.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC61266; BAC61266; BAC61266.
GeneID1190595.
KEGGvpa:VP3003.
PATRIC20144276. VBIVibPar50997_2888.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0248.
HOGENOMHOG000258672.
KOK01524.
OMAPPRVAEH.
OrthoDBEOG6M6JN6.
ProtClustDBPRK11031.

Enzyme and pathway databases

BioCycVPAR223926:GHK4-3139-MONOMER.
UniPathwayUPA00908; UER00884.

Family and domain databases

HAMAPMF_01550. GppA.
InterProIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamPF02541. Ppx-GppA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPPA_VIBPA
AccessionPrimary (citable) accession number: Q87KH4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2003
Last modified: February 19, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways