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Q87KH4

- GPPA_VIBPA

UniProt

Q87KH4 - GPPA_VIBPA

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Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene
gppA, VP3003
Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. guanosine pentaphosphate catabolic process Source: InterPro
  2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciVPAR223926:GHK4-3139-MONOMER.
UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (EC:3.6.1.40)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene namesi
Name:gppA
Ordered Locus Names:VP3003
OrganismiVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Taxonomic identifieri223926 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002493: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotationPRO_0000194294Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi223926.VP3003.

Structurei

3D structure databases

ProteinModelPortaliQ87KH4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OMAiSYVHWAL.
OrthoDBiEOG6M6JN6.

Family and domain databases

HAMAPiMF_01550. GppA.
InterProiIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q87KH4-1 [UniParc]FASTAAdd to Basket

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MSQAGSSPLY AAIDLGSNSF HMLVVRHIDG SVQTMAKIKR KVRLAAGLDE    50
HNSLSMEAMQ RGWDCLSLFA ERLQDIPTQN IRIVGTATLR TATNVDVFLE 100
KANQILGQPI EVISGEEEAA TIYKGVAHTS GGSGRRLVVD IGGASTELII 150
GEGFEAKALT SLKMGCVTWL ENFFKDRQLN ARNFEAAIEG AKQTIKPILE 200
QYTDLGWDVC VGASGTVQAL QEIMLAQGMD EVITHSKLKR LQKQAMLADH 250
LEELDIEGLT LERALVFPSG LSILIAIFEL LEIDAMTLAG GALREGLVYE 300
MVDELRQNDI RARTICSVQS RYQLDCQYGE QVATLAGKLL EQAGGDEWIA 350
EPQGKVLLET TAKLHEIGLT IDFKKGGEHS AYLLQNLDLP GYTRAQKFFI 400
GEIARRYREQ LSSLPEQHAI SGTSAKRVLR LLRLAVLLTH RRNPSLEPQV 450
ELLAEGDKLT LSIDAKWLEA NPLTAAELEI ESNRQTDIGW PLTITAC 497
Length:497
Mass (Da):54,689
Last modified:June 1, 2003 - v1
Checksum:i28977E25011DD2CB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000031 Genomic DNA. Translation: BAC61266.1.
RefSeqiNP_799382.1. NC_004603.1.

Genome annotation databases

EnsemblBacteriaiBAC61266; BAC61266; BAC61266.
GeneIDi1190595.
KEGGivpa:VP3003.
PATRICi20144276. VBIVibPar50997_2888.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000031 Genomic DNA. Translation: BAC61266.1 .
RefSeqi NP_799382.1. NC_004603.1.

3D structure databases

ProteinModelPortali Q87KH4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 223926.VP3003.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC61266 ; BAC61266 ; BAC61266 .
GeneIDi 1190595.
KEGGi vpa:VP3003.
PATRICi 20144276. VBIVibPar50997_2888.

Phylogenomic databases

eggNOGi COG0248.
HOGENOMi HOG000258672.
KOi K01524.
OMAi SYVHWAL.
OrthoDBi EOG6M6JN6.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .
BioCyci VPAR223926:GHK4-3139-MONOMER.

Family and domain databases

HAMAPi MF_01550. GppA.
InterProi IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view ]
Pfami PF02541. Ppx-GppA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
    Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
    Lancet 361:743-749(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RIMD 2210633.

Entry informationi

Entry nameiGPPA_VIBPA
AccessioniPrimary (citable) accession number: Q87KH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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