Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q87JS8 (SPEA_VIBPA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Biosynthetic arginine decarboxylase

Short name=ADC
EC=4.1.1.19
Gene names
Name:speA
Ordered Locus Names:VPA0170
OrganismVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) [Complete proteome] [HAMAP]
Taxonomic identifier223926 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length640 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the biosynthesis of agmatine from arginine By similarity. HAMAP-Rule MF_01417

Catalytic activity

L-arginine = agmatine + CO2. HAMAP-Rule MF_01417

Cofactor

Magnesium By similarity. HAMAP-Rule MF_01417

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01417

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 640640Biosynthetic arginine decarboxylase HAMAP-Rule MF_01417
PRO_0000149984

Regions

Region290 – 30011Substrate-binding Potential

Amino acid modifications

Modified residue1051N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q87JS8 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 17371F21185F27A7

FASTA64072,065
        10         20         30         40         50         60 
MRIELEKATK LDRIRADYNV HYWSQGFYGI DDQGEVYVSP RSDRAHQIPF SAIVNELEAQ 

        70         80         90        100        110        120 
QLNLPVLVRF PQIVHQRVHG ICHAFNQAIE EYQYPNKYLL VYPIKVNQQR EVVDEILASQ 

       130        140        150        160        170        180 
AQLETKQLGL EAGSKPELLA VLALAQQGSS VIVCNGYKDR EYVRLALIGE KLGHKVFIVL 

       190        200        210        220        230        240 
EKLSELDLVL EEAKSLGVKP RLGLRIRLAS QGAGKWQASG GEKSKFGLSA SQVLSVIERL 

       250        260        270        280        290        300 
KREGSLDAMQ LVHFHLGSQM ANIRDVRNGV NESARFYCEL RALGANIEYF DVGGGLAVDY 

       310        320        330        340        350        360 
DGTRSQSSNS MNYGLAEYAR NIVNTVGDVC QQYEQPMPVI ISESGRSLTA HHAVLISNVI 

       370        380        390        400        410        420 
GTETYQPEEV HELGVDAPLL LQNMWRNWEN LQDGTDARAL IEIYNDTQSD LAEVHSQFAT 

       430        440        450        460        470        480 
GVLNLEQRAW AEQLSLRIYF ELSRKMSTKN RFHRPILDEL SERLADKFFV NFSLFQSLPD 

       490        500        510        520        530        540 
AWGIDQVFPV LPLSGLGDAE ERRAVMLDIT CDSDGAIDHY VDGQGIESTL PVPAWSKDKP 

       550        560        570        580        590        600 
YLMGFFLVGA YQEILGDMHN LFGDTHSAVV NVDEHGQFEI SYINEGDSVE DMMRYVHIDV 

       610        620        630        640 
DAIRDNYKQL VSQRVEANEQ AQILAELEQG LAGYTYLEDF 

« Hide

References

[1]"Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
Lancet 361:743-749(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RIMD 2210633.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000032 Genomic DNA. Translation: BAC61513.1.
RefSeqNP_799680.1. NC_004605.1.

3D structure databases

ProteinModelPortalQ87JS8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING223926.VPA0170.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC61513; BAC61513; BAC61513.
GeneID1190857.
KEGGvpa:VPA0170.
PATRIC20144787. VBIVibPar50997_3128.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1166.
HOGENOMHOG000029191.
KOK01585.
OMAMIHFHIG.
OrthoDBEOG676Z0R.
ProtClustDBPRK05354.

Enzyme and pathway databases

BioCycVPAR223926:GHK4-3401-MONOMER.

Family and domain databases

Gene3D2.40.37.10. 2 hits.
HAMAPMF_01417. SpeA.
InterProIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
[Graphical view]
PfamPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
TIGRFAMsTIGR01273. speA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSPEA_VIBPA
AccessionPrimary (citable) accession number: Q87JS8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: June 1, 2003
Last modified: February 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families