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Q87JS8

- SPEA_VIBPA

UniProt

Q87JS8 - SPEA_VIBPA

Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

    Catalytic activityi

    L-arginine = agmatine + CO2.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation
    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. arginine decarboxylase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. arginine catabolic process Source: InterPro
    2. spermidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Polyamine biosynthesis, Spermidine biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding, Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciVPAR223926:GHK4-3401-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
    Short name:
    ADCUniRule annotation
    Gene namesi
    Name:speAUniRule annotation
    Ordered Locus Names:VPA0170
    OrganismiVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
    Taxonomic identifieri223926 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000002493: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 640640Biosynthetic arginine decarboxylasePRO_0000149984Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei105 – 1051N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi223926.VPA0170.

    Structurei

    3D structure databases

    ProteinModelPortaliQ87JS8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni290 – 30011Substrate-bindingUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1166.
    HOGENOMiHOG000029191.
    KOiK01585.
    OMAiIDHYVDG.
    OrthoDBiEOG676Z0R.

    Family and domain databases

    Gene3Di2.40.37.10. 2 hits.
    3.20.20.10. 1 hit.
    HAMAPiMF_01417. SpeA.
    InterProiIPR009006. Ala_racemase/Decarboxylase_C.
    IPR002985. Arg_decrbxlase.
    IPR022643. De-COase2_C.
    IPR022644. De-COase2_N.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
    PRINTSiPR01180. ARGDCRBXLASE.
    PR01179. ODADCRBXLASE.
    SUPFAMiSSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR01273. speA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q87JS8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRIELEKATK LDRIRADYNV HYWSQGFYGI DDQGEVYVSP RSDRAHQIPF    50
    SAIVNELEAQ QLNLPVLVRF PQIVHQRVHG ICHAFNQAIE EYQYPNKYLL 100
    VYPIKVNQQR EVVDEILASQ AQLETKQLGL EAGSKPELLA VLALAQQGSS 150
    VIVCNGYKDR EYVRLALIGE KLGHKVFIVL EKLSELDLVL EEAKSLGVKP 200
    RLGLRIRLAS QGAGKWQASG GEKSKFGLSA SQVLSVIERL KREGSLDAMQ 250
    LVHFHLGSQM ANIRDVRNGV NESARFYCEL RALGANIEYF DVGGGLAVDY 300
    DGTRSQSSNS MNYGLAEYAR NIVNTVGDVC QQYEQPMPVI ISESGRSLTA 350
    HHAVLISNVI GTETYQPEEV HELGVDAPLL LQNMWRNWEN LQDGTDARAL 400
    IEIYNDTQSD LAEVHSQFAT GVLNLEQRAW AEQLSLRIYF ELSRKMSTKN 450
    RFHRPILDEL SERLADKFFV NFSLFQSLPD AWGIDQVFPV LPLSGLGDAE 500
    ERRAVMLDIT CDSDGAIDHY VDGQGIESTL PVPAWSKDKP YLMGFFLVGA 550
    YQEILGDMHN LFGDTHSAVV NVDEHGQFEI SYINEGDSVE DMMRYVHIDV 600
    DAIRDNYKQL VSQRVEANEQ AQILAELEQG LAGYTYLEDF 640
    Length:640
    Mass (Da):72,065
    Last modified:June 1, 2003 - v1
    Checksum:i17371F21185F27A7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000032 Genomic DNA. Translation: BAC61513.1.
    RefSeqiNP_799680.1. NC_004605.1.

    Genome annotation databases

    EnsemblBacteriaiBAC61513; BAC61513; BAC61513.
    GeneIDi1190857.
    KEGGivpa:VPA0170.
    PATRICi20144787. VBIVibPar50997_3128.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000032 Genomic DNA. Translation: BAC61513.1 .
    RefSeqi NP_799680.1. NC_004605.1.

    3D structure databases

    ProteinModelPortali Q87JS8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 223926.VPA0170.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC61513 ; BAC61513 ; BAC61513 .
    GeneIDi 1190857.
    KEGGi vpa:VPA0170.
    PATRICi 20144787. VBIVibPar50997_3128.

    Phylogenomic databases

    eggNOGi COG1166.
    HOGENOMi HOG000029191.
    KOi K01585.
    OMAi IDHYVDG.
    OrthoDBi EOG676Z0R.

    Enzyme and pathway databases

    BioCyci VPAR223926:GHK4-3401-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 2 hits.
    3.20.20.10. 1 hit.
    HAMAPi MF_01417. SpeA.
    InterProi IPR009006. Ala_racemase/Decarboxylase_C.
    IPR002985. Arg_decrbxlase.
    IPR022643. De-COase2_C.
    IPR022644. De-COase2_N.
    IPR000183. Orn/DAP/Arg_de-COase.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF02784. Orn_Arg_deC_N. 1 hit.
    PF00278. Orn_DAP_Arg_deC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
    PRINTSi PR01180. ARGDCRBXLASE.
    PR01179. ODADCRBXLASE.
    SUPFAMi SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR01273. speA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
      Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
      Lancet 361:743-749(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RIMD 2210633.

    Entry informationi

    Entry nameiSPEA_VIBPA
    AccessioniPrimary (citable) accession number: Q87JS8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3