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Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation
  • pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPolyamine biosynthesis, Spermidine biosynthesis
LigandMagnesium, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciVPAR223926:G1GTB-3400-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
Short name:
ADCUniRule annotation
Gene namesi
Name:speAUniRule annotation
Ordered Locus Names:VPA0170
OrganismiVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Taxonomic identifieri223926 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000002493 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001499841 – 640Biosynthetic arginine decarboxylaseAdd BLAST640

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei105N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ87JS8

Interactioni

Protein-protein interaction databases

STRINGi223926.VPA0170

Structurei

3D structure databases

ProteinModelPortaliQ87JS8
SMRiQ87JS8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni290 – 300Substrate-bindingUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DP5 Bacteria
COG1166 LUCA
HOGENOMiHOG000029191
KOiK01585
OMAiLFPIMPI

Family and domain databases

CDDicd06830 PLPDE_III_ADC, 1 hit
Gene3Di2.40.37.10, 3 hits
3.20.20.10, 1 hit
HAMAPiMF_01417 SpeA, 1 hit
InterProiView protein in InterPro
IPR009006 Ala_racemase/Decarboxylase_C
IPR002985 Arg_decrbxlase
IPR022644 De-COase2_N
IPR000183 Orn/DAP/Arg_de-COase
IPR029066 PLP-binding_barrel
PANTHERiPTHR43295 PTHR43295, 1 hit
PfamiView protein in Pfam
PF02784 Orn_Arg_deC_N, 1 hit
PIRSFiPIRSF001336 Arg_decrbxlase, 1 hit
PRINTSiPR01180 ARGDCRBXLASE
PR01179 ODADCRBXLASE
SUPFAMiSSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR01273 speA, 1 hit

Sequencei

Sequence statusi: Complete.

Q87JS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIELEKATK LDRIRADYNV HYWSQGFYGI DDQGEVYVSP RSDRAHQIPF
60 70 80 90 100
SAIVNELEAQ QLNLPVLVRF PQIVHQRVHG ICHAFNQAIE EYQYPNKYLL
110 120 130 140 150
VYPIKVNQQR EVVDEILASQ AQLETKQLGL EAGSKPELLA VLALAQQGSS
160 170 180 190 200
VIVCNGYKDR EYVRLALIGE KLGHKVFIVL EKLSELDLVL EEAKSLGVKP
210 220 230 240 250
RLGLRIRLAS QGAGKWQASG GEKSKFGLSA SQVLSVIERL KREGSLDAMQ
260 270 280 290 300
LVHFHLGSQM ANIRDVRNGV NESARFYCEL RALGANIEYF DVGGGLAVDY
310 320 330 340 350
DGTRSQSSNS MNYGLAEYAR NIVNTVGDVC QQYEQPMPVI ISESGRSLTA
360 370 380 390 400
HHAVLISNVI GTETYQPEEV HELGVDAPLL LQNMWRNWEN LQDGTDARAL
410 420 430 440 450
IEIYNDTQSD LAEVHSQFAT GVLNLEQRAW AEQLSLRIYF ELSRKMSTKN
460 470 480 490 500
RFHRPILDEL SERLADKFFV NFSLFQSLPD AWGIDQVFPV LPLSGLGDAE
510 520 530 540 550
ERRAVMLDIT CDSDGAIDHY VDGQGIESTL PVPAWSKDKP YLMGFFLVGA
560 570 580 590 600
YQEILGDMHN LFGDTHSAVV NVDEHGQFEI SYINEGDSVE DMMRYVHIDV
610 620 630 640
DAIRDNYKQL VSQRVEANEQ AQILAELEQG LAGYTYLEDF
Length:640
Mass (Da):72,065
Last modified:June 1, 2003 - v1
Checksum:i17371F21185F27A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000032 Genomic DNA Translation: BAC61513.1
RefSeqiNP_799680.1, NC_004605.1
WP_005459323.1, NC_004605.1

Genome annotation databases

EnsemblBacteriaiBAC61513; BAC61513; BAC61513
GeneIDi1190857
KEGGivpa:VPA0170
PATRICifig|223926.6.peg.3128

Similar proteinsi

Entry informationi

Entry nameiSPEA_VIBPA
AccessioniPrimary (citable) accession number: Q87JS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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