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Q87JE4 (PNCB_VIBPA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nicotinate phosphoribosyltransferase

Short name=NAPRTase
EC=6.3.4.21
Gene names
Name:pncB
Ordered Locus Names:VPA0309
OrganismVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) [Complete proteome] [HAMAP]
Taxonomic identifier223926 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length436 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity. HAMAP-Rule MF_00570

Catalytic activity

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate. HAMAP-Rule MF_00570

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP-Rule MF_00570

Sequence similarities

Belongs to the NAPRTase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 436436Nicotinate phosphoribosyltransferase HAMAP-Rule MF_00570
PRO_0000205848

Sequences

Sequence LengthMass (Da)Tools
Q87JE4 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: A9B4404D6D35D780

FASTA43650,210
        10         20         30         40         50         60 
MTTTLFSSRI IQSALDFDVY KVNMMSAVAA LYPDAMVSYK FIVRSEEDLS ELLPEVKAEV 

        70         80         90        100        110        120 
LKLQDVRFTE DEIAYMKRVA PYLKPEFVEA LRHFRFNPQS DVSFHNKTMS DGSSQLRITI 

       130        140        150        160        170        180 
NGLWKETILY ETIIMSIVSE VRSRQRWSDI PFEQFQTVLE DKVRYLKAEL ERRNITNFKF 

       190        200        210        220        230        240 
ADMSTRRRFS FQAQRTMLEY LSKELPQCLT GTSNYHLARE LDLTPIGTVA HEWFMGHQAL 

       250        260        270        280        290        300 
VNVRDSQKIA LQRWQKMFNG ALGIALTDTI GIDAFLKDFD EELSHAYVGV RHDSGCPFTW 

       310        320        330        340        350        360 
GEKMIAHYES LGIDPMTKTL VFTDGLNFEQ ALDICEHFQG RVQVSFGIGT SLANDMGNYV 

       370        380        390        400        410        420 
NDQGEAYQPL SIVIKMVTCN GSPVAKISDE PEKAMCEDIF FLMNLKRRFE QPLDLNECRK 

       430 
LIDRLESEGQ NYLIDA 

« Hide

References

[1]"Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
Lancet 361:743-749(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RIMD 2210633.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000032 Genomic DNA. Translation: BAC61652.1.
RefSeqNP_799819.1. NC_004605.1.

3D structure databases

ProteinModelPortalQ87JE4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING223926.VPA0309.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC61652; BAC61652; BAC61652.
GeneID1190997.
KEGGvpa:VPA0309.
PATRIC20145055. VBIVibPar50997_3261.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1488.
HOGENOMHOG000284928.
KOK00763.
OMAQAVFHRY.
OrthoDBEOG6X10XB.

Enzyme and pathway databases

BioCycVPAR223926:GHK4-3541-MONOMER.
UniPathwayUPA00253; UER00457.

Family and domain databases

HAMAPMF_00570. NAPRTase.
InterProIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PfamPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFPIRSF000484. NAPRT. 1 hit.
SUPFAMSSF51690. SSF51690. 1 hit.
TIGRFAMsTIGR01514. NAPRTase. 1 hit.
ProtoNetSearch...

Entry information

Entry namePNCB_VIBPA
AccessionPrimary (citable) accession number: Q87JE4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways