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Q87JE4

- PNCB_VIBPA

UniProt

Q87JE4 - PNCB_VIBPA

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Protein
Nicotinate phosphoribosyltransferase
Gene
pncB, VPA0309
Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate phosphoribosyltransferase activity Source: InterPro
  3. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciVPAR223926:GHK4-3541-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
Short name:
NAPRTase
Gene namesi
Name:pncB
Ordered Locus Names:VPA0309
OrganismiVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Taxonomic identifieri223926 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002493: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436Nicotinate phosphoribosyltransferaseUniRule annotation
PRO_0000205848Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi223926.VPA0309.

Structurei

3D structure databases

ProteinModelPortaliQ87JE4.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
KOiK00763.
OMAiQAVFHRY.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q87JE4-1 [UniParc]FASTAAdd to Basket

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MTTTLFSSRI IQSALDFDVY KVNMMSAVAA LYPDAMVSYK FIVRSEEDLS    50
ELLPEVKAEV LKLQDVRFTE DEIAYMKRVA PYLKPEFVEA LRHFRFNPQS 100
DVSFHNKTMS DGSSQLRITI NGLWKETILY ETIIMSIVSE VRSRQRWSDI 150
PFEQFQTVLE DKVRYLKAEL ERRNITNFKF ADMSTRRRFS FQAQRTMLEY 200
LSKELPQCLT GTSNYHLARE LDLTPIGTVA HEWFMGHQAL VNVRDSQKIA 250
LQRWQKMFNG ALGIALTDTI GIDAFLKDFD EELSHAYVGV RHDSGCPFTW 300
GEKMIAHYES LGIDPMTKTL VFTDGLNFEQ ALDICEHFQG RVQVSFGIGT 350
SLANDMGNYV NDQGEAYQPL SIVIKMVTCN GSPVAKISDE PEKAMCEDIF 400
FLMNLKRRFE QPLDLNECRK LIDRLESEGQ NYLIDA 436
Length:436
Mass (Da):50,210
Last modified:June 1, 2003 - v1
Checksum:iA9B4404D6D35D780
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000032 Genomic DNA. Translation: BAC61652.1.
RefSeqiNP_799819.1. NC_004605.1.

Genome annotation databases

EnsemblBacteriaiBAC61652; BAC61652; BAC61652.
GeneIDi1190997.
KEGGivpa:VPA0309.
PATRICi20145055. VBIVibPar50997_3261.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000032 Genomic DNA. Translation: BAC61652.1 .
RefSeqi NP_799819.1. NC_004605.1.

3D structure databases

ProteinModelPortali Q87JE4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 223926.VPA0309.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC61652 ; BAC61652 ; BAC61652 .
GeneIDi 1190997.
KEGGi vpa:VPA0309.
PATRICi 20145055. VBIVibPar50997_3261.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000284928.
KOi K00763.
OMAi QAVFHRY.
OrthoDBi EOG6X10XB.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .
BioCyci VPAR223926:GHK4-3541-MONOMER.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
    Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
    Lancet 361:743-749(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RIMD 2210633.

Entry informationi

Entry nameiPNCB_VIBPA
AccessioniPrimary (citable) accession number: Q87JE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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