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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (pncB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Transferase
Biological processPyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciVPAR223926:G1GTB-3540-MONOMER
UniPathwayiUPA00253; UER00457

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:VPA0309
OrganismiVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Taxonomic identifieri223926 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000002493 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002058481 – 436Nicotinate phosphoribosyltransferaseAdd BLAST436

Interactioni

Protein-protein interaction databases

STRINGi223926.VPA0309

Structurei

3D structure databases

ProteinModelPortaliQ87JE4
SMRiQ87JE4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RH7 Bacteria
COG1488 LUCA
HOGENOMiHOG000284928
KOiK00763
OMAiKLTMQCA

Family and domain databases

CDDicd01401 PncB_like, 1 hit
HAMAPiMF_00570 NAPRTase, 1 hit
InterProiView protein in InterPro
IPR006406 Nic_PRibTrfase
IPR007229 Nic_PRibTrfase-Fam
IPR036068 Nicotinate_pribotase_like_C
PANTHERiPTHR11098 PTHR11098, 1 hit
PfamiView protein in Pfam
PF04095 NAPRTase, 1 hit
PIRSFiPIRSF000484 NAPRT, 1 hit
SUPFAMiSSF51690 SSF51690, 1 hit
TIGRFAMsiTIGR01514 NAPRTase, 1 hit

Sequencei

Sequence statusi: Complete.

Q87JE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTTLFSSRI IQSALDFDVY KVNMMSAVAA LYPDAMVSYK FIVRSEEDLS
60 70 80 90 100
ELLPEVKAEV LKLQDVRFTE DEIAYMKRVA PYLKPEFVEA LRHFRFNPQS
110 120 130 140 150
DVSFHNKTMS DGSSQLRITI NGLWKETILY ETIIMSIVSE VRSRQRWSDI
160 170 180 190 200
PFEQFQTVLE DKVRYLKAEL ERRNITNFKF ADMSTRRRFS FQAQRTMLEY
210 220 230 240 250
LSKELPQCLT GTSNYHLARE LDLTPIGTVA HEWFMGHQAL VNVRDSQKIA
260 270 280 290 300
LQRWQKMFNG ALGIALTDTI GIDAFLKDFD EELSHAYVGV RHDSGCPFTW
310 320 330 340 350
GEKMIAHYES LGIDPMTKTL VFTDGLNFEQ ALDICEHFQG RVQVSFGIGT
360 370 380 390 400
SLANDMGNYV NDQGEAYQPL SIVIKMVTCN GSPVAKISDE PEKAMCEDIF
410 420 430
FLMNLKRRFE QPLDLNECRK LIDRLESEGQ NYLIDA
Length:436
Mass (Da):50,210
Last modified:June 1, 2003 - v1
Checksum:iA9B4404D6D35D780
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000032 Genomic DNA Translation: BAC61652.1
RefSeqiNP_799819.1, NC_004605.1
WP_005479835.1, NC_004605.1

Genome annotation databases

EnsemblBacteriaiBAC61652; BAC61652; BAC61652
GeneIDi1190997
KEGGivpa:VPA0309
PATRICifig|223926.6.peg.3261

Similar proteinsi

Entry informationi

Entry nameiPNCB_VIBPA
AccessioniPrimary (citable) accession number: Q87JE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health