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Protein

Histidine kinase

Gene

VPA0675

Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotation, Transferase

Keywords - Biological processi

Two-component regulatory systemSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciVPAR223926:GHK4-3908-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine kinaseSAAS annotation (EC:2.7.13.3SAAS annotation)
Gene namesi
Ordered Locus Names:VPA0675Imported
OrganismiVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)Imported
Taxonomic identifieri223926 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000002493 Componenti: Chromosome 2

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3726HelicalSequence analysisAdd
BLAST
Transmembranei334 – 35522HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

DIPiDIP-48299N.
STRINGi223926.VPA0675.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3I9YX-ray2.16A51-322[»]
3O1HX-ray3.10A51-322[»]
3O1IX-ray2.80A/B51-322[»]
3O1JX-ray2.95A/B51-322[»]
ProteinModelPortaliQ87ID1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ87ID1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini360 – 41253HAMPInterPro annotationAdd
BLAST
Domaini476 – 694219Histidine kinaseInterPro annotationAdd
BLAST
Domaini713 – 836124Response regulatoryInterPro annotationAdd
BLAST
Domaini894 – 98895HPtInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili140 – 16324Sequence analysisAdd
BLAST
Coiled coili413 – 46957Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains histidine kinase domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
HOGENOMiHOG000217952.
KOiK07647.
OMAiIAVSAHV.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
1.20.120.160. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
IPR008207. Sig_transdc_His_kin_Hpt_dom.
IPR014302. Sig_transdc_His_kinase_TorS.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF01627. Hpt. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PIRSFiPIRSF036437. HK_TorS. 1 hit.
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF47226. SSF47226. 1 hit.
SSF47384. SSF47384. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR02956. TMAO_torS. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
PS50894. HPT. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q87ID1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLATASIGR KLLLSFIAMA MLVMLSALIG VSGFSLVAKT ERNVVDAAIP
60 70 80 90 100
AMIEARQVSE LSTRIISSVQ MLSNAQNEQE RKEAGRVLFE QLESLLTHIK
110 120 130 140 150
ELGGESFDSK LLDALESNVQ NVINNLAELG VTVERKLWLA KEIDTRVEEM
160 170 180 190 200
RLLSEELEQL TRTQVQNTST IAVANVTHIY DLLEANKKDQ VYQALDALVE
210 220 230 240 250
VDLDLTERLH ELHLLAFKML NQIEEARTLT NVDRIQQIQT AFENNLKIMK
260 270 280 290 300
RRVLAVEDPT RSKQMSQLLT ELGKRQVVFT ILLQQYENNE QSQQLMQKTL
310 320 330 340 350
ELFSELNSTV NKLVDDSNKT TTFAVDQLTN TLKFAQWSLT VISIVGLIVV
360 370 380 390 400
VLILWRVVYV SVVKRLAEYS AALLSVAQGN LAVELEVKGK DELAHMGQAI
410 420 430 440 450
ITARNTAQAL KVVAEGEAKA KRELEEHKEH LEELIEQRTS QLRQANLRLN
460 470 480 490 500
EEVVNHAQAR NEAEQASRAK SAFLATMSHE IRTPMNGVLG TARLLMDSGL
510 520 530 540 550
NPIQKRYAEI INRSGKTLLA ILNDVLDYSK IEAGHLEIRR LGFDLHQMVE
560 570 580 590 600
DTFQLMNSRA QEKQLLFSYH IESDVSRYWK GDVTRISQVL NNLVGNAIKF
610 620 630 640 650
TEDGEIDIYV SLNPEDESQV LFEVSDTGIG ISKKDQKTLF DAFTQAEGGL
660 670 680 690 700
NQIGGTGLGL AISKRIVEAM GGVLEVDSEE GEGSRFWFSI PLEESEPVEI
710 720 730 740 750
GVVASARCKV KAKVLLVEDN EVNRVVAEGF LQSMGHQVVM AEDGLQAERI
760 770 780 790 800
IDKQDFDIAL VDINLPDCDG TDLIQRLKRI ERNKPGDKAL SPTPMIAVSA
810 820 830 840 850
HVFAEEVERY LAAGFDGYLP KPVEKEALAT LIQDVLDGKQ LLLPQSGECL
860 870 880 890 900
PLSETSDTNL TIENQVEQDH QQREEPEMVI INPSVIQSDM KILGREKMLH
910 920 930 940 950
IIDLFRNTSA DVLGQLVESA EKNDSLAVKN LAHKLKGSAG SLGLTALMNT
960 970 980
CQSIEIAAEP LDTYNAQQGL LDEQVATSVN ALDELMAE
Length:988
Mass (Da):109,883
Last modified:June 1, 2003 - v1
Checksum:i962F67DF6A44BC72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000032 Genomic DNA. Translation: BAC62018.1.
RefSeqiNP_800185.1. NC_004605.1.
WP_005477577.1. NC_004605.1.

Genome annotation databases

EnsemblBacteriaiBAC62018; BAC62018; BAC62018.
GeneIDi1191364.
KEGGivpa:VPA0675.
PATRICi20145757. VBIVibPar50997_3611.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000032 Genomic DNA. Translation: BAC62018.1.
RefSeqiNP_800185.1. NC_004605.1.
WP_005477577.1. NC_004605.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3I9YX-ray2.16A51-322[»]
3O1HX-ray3.10A51-322[»]
3O1IX-ray2.80A/B51-322[»]
3O1JX-ray2.95A/B51-322[»]
ProteinModelPortaliQ87ID1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48299N.
STRINGi223926.VPA0675.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC62018; BAC62018; BAC62018.
GeneIDi1191364.
KEGGivpa:VPA0675.
PATRICi20145757. VBIVibPar50997_3611.

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
HOGENOMiHOG000217952.
KOiK07647.
OMAiIAVSAHV.

Enzyme and pathway databases

BioCyciVPAR223926:GHK4-3908-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ87ID1.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
1.20.120.160. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
IPR008207. Sig_transdc_His_kin_Hpt_dom.
IPR014302. Sig_transdc_His_kinase_TorS.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF01627. Hpt. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PIRSFiPIRSF036437. HK_TorS. 1 hit.
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF47226. SSF47226. 1 hit.
SSF47384. SSF47384. 1 hit.
SSF52172. SSF52172. 1 hit.
SSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR02956. TMAO_torS. 1 hit.
PROSITEiPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
PS50894. HPT. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ87ID1_VIBPA
AccessioniPrimary (citable) accession number: Q87ID1
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.