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Protein

Catalase-peroxidase 2

Gene

katG2

Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei95 – 951Transition state stabilizerUniRule annotation
Active sitei99 – 991Proton acceptorUniRule annotation
Metal bindingi267 – 2671Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciVPAR223926:GHK4-4001-MONOMER.

Protein family/group databases

PeroxiBasei2656. VpCP02_RIMD2210633.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidase 2UniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CP 2UniRule annotation
Alternative name(s):
Peroxidase/catalase 2UniRule annotation
Gene namesi
Name:katG2UniRule annotation
Ordered Locus Names:VPA0768
OrganismiVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Taxonomic identifieri223926 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000002493 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 724724Catalase-peroxidase 2PRO_0000354951Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki98 ↔ 226Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-252)UniRule annotation
Cross-linki226 ↔ 252Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-98)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiQ87I38.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi223926.VPA0768.

Structurei

3D structure databases

ProteinModelPortaliQ87I38.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiQPEEMML.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q87I38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNTNGGSVG KCPVMHGGQT STDKSVMDWW PNALNLDILH QHDSKTNPFG
60 70 80 90 100
PDFNYKEELK KLDVDALKQD LKDLMTNSQV WWPADWGHYG GLMIRMAWHA
110 120 130 140 150
AGSYRIADGR GGAATGNQRF APLNSWPDNA NLDKARRLLW PIKRKYGNKL
160 170 180 190 200
SWADLIILAG NMAYESMGFK TFGFGFGRED IWHPEKDTYW GSEQEWLAPS
210 220 230 240 250
GAKNSRYSGE RDLENPLAAV MMGLIYVNPE GVDGNPDPLK TAQDMRVTFA
260 270 280 290 300
RMAMNDEETV ALTAGGHTVG KCHGNGDAAN LGPDPEGADV HEQGLGWMNH
310 320 330 340 350
KTRGIGRDTV TSGLEGAWTT HPTQWDNGYF YLLFKYDWEL KKSPAGAWQW
360 370 380 390 400
EPIDIEEQDK PVDVEDGSKR YNPIMTDADM ALKMDPEYRK ISERFQQDPA
410 420 430 440 450
YFEDMFARAW FKLTHRDMGP KSCYLGPDVP SEDLIWQDPT PAGKTDYNVD
460 470 480 490 500
LVKGKIEASG LSIADLVATA WDSARTYRGS DRRGGANGAR IRLAPQKDWQ
510 520 530 540 550
GNEPERLSRV LAVLESIAAE EGCSVADAIV LAGNVGIELA ARAAGHDVSV
560 570 580 590 600
PFAPGRGDAS QDMTDVESFE VLEPVADGFR NWLKKDYVVK PEELLLDRAQ
610 620 630 640 650
LMGLTAPEMT VLIGGLRVLG SNYGGSKDGV FTDRVGTLSN DFFVNLTDMA
660 670 680 690 700
YTWKPAGENQ YEIRDRKTDQ VKWTATRVDL VFGSNSILRS YAEVYAQDDN
710 720
QEKFIHDFVA AWTKVMNADR FDLQ
Length:724
Mass (Da):80,704
Last modified:June 1, 2003 - v1
Checksum:i6F552DAA3ECD9EA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000032 Genomic DNA. Translation: BAC62111.1.
RefSeqiNP_800278.1. NC_004605.1.
WP_005481286.1. NC_004605.1.

Genome annotation databases

EnsemblBacteriaiBAC62111; BAC62111; BAC62111.
GeneIDi1191457.
KEGGivpa:VPA0768.
PATRICi20145937. VBIVibPar50997_3701.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000032 Genomic DNA. Translation: BAC62111.1.
RefSeqiNP_800278.1. NC_004605.1.
WP_005481286.1. NC_004605.1.

3D structure databases

ProteinModelPortaliQ87I38.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi223926.VPA0768.

Protein family/group databases

PeroxiBasei2656. VpCP02_RIMD2210633.

Proteomic databases

PRIDEiQ87I38.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC62111; BAC62111; BAC62111.
GeneIDi1191457.
KEGGivpa:VPA0768.
PATRICi20145937. VBIVibPar50997_3701.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiQPEEMML.

Enzyme and pathway databases

BioCyciVPAR223926:GHK4-4001-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG2_VIBPA
AccessioniPrimary (citable) accession number: Q87I38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: June 1, 2003
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.