Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q87I05

- GCSP_VIBPA

UniProt

Q87I05 - GCSP_VIBPA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciVPAR223926:GHK4-4034-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:VPA0801
OrganismiVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Taxonomic identifieri223926 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002493: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 954954Glycine dehydrogenase (decarboxylating)PRO_0000166945Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei704 – 7041N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PRIDEiQ87I05.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi223926.VPA0801.

Structurei

3D structure databases

ProteinModelPortaliQ87I05.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiIRVQVII.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q87I05-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTELLQSLST QNEFVGRHNG PKLSDQQKML EAINAVSLDA LISETVPANI
60 70 80 90 100
RLEQPMTLAE AKSEADMLAT MKQFAKQNQV KRTFIGQGYY NTFTPNVILR
110 120 130 140 150
NVLENPGWYT AYTPYQPEIS QGRLESLLNF QQMVIDLTGM EIANASLLDE
160 170 180 190 200
ATAAAEAMTL CKRAGKSKSN VFFVADDVHP QTIEVVKTRA KFIGFEVLVG
210 220 230 240 250
SLESLPEQDV FGALVQYPST TGEVRDLTDI IAKAQANKTL VTVATDLLAC
260 270 280 290 300
TLLKPAGEMG ADVAIGSAQR FGVPMGYGGP HAAFMATRDK HKRTMPGRVI
310 320 330 340 350
GVSIDAKGNQ ALRMAMQTRE QHIRREKATS NICTAQALLA NMASFYAVYH
360 370 380 390 400
GAEGLRTIAR RTHHMTAILA AGLTKGGFEL AHNSFFDTIT INTGEKTQDL
410 420 430 440 450
YTKALAADIN LRVLPGKLGI SLDETTTVAD VEALFAIFGV KEDVTALSTE
460 470 480 490 500
VAGNEFAAIP EALRRTSEYL THPVFNTYHS ETQMMRYLKQ LENKDFSLTH
510 520 530 540 550
GMIPLGSCTM KLNAAAEMIP ITWPEFGSIH PFAPAEQAAG YAALAKDLKE
560 570 580 590 600
KLCEITGYDA FSLQPNSGAS GEYAGLIAIQ RYHESRGEGH RNVCLIPSSA
610 620 630 640 650
HGTNPATASM VSMKVVVVKC DDEGNIDIDD LAAKIEKHKD NLSSIMITYP
660 670 680 690 700
STHGVYEEKV KEVCEMVHAA GGQVYLDGAN MNAQVGLTSP GFIGSDVSHL
710 720 730 740 750
NLHKTFCIPH GGGGPGMGPI GVKSHLAPFL PGHIENGVEG EDFAVSAADF
760 770 780 790 800
GSASILPISW AYIAMMGEAG LSNATKVAIL NANYVMERLR PHYPVLYRGK
810 820 830 840 850
NGRVAHECII DIRPLKEETG ISEEDIAKRL MDYGFHAPTM SFPVAGTLMV
860 870 880 890 900
EPTESEDLAE LNRFCDAMIS IREEMTKVKN GEWPLENNPL VNAPHTQVDL
910 920 930 940 950
SAEEWDRPYS RELGCFPSKA TKSWKYWPTV NRVDNVYGDR NLICSCPSID

NYED
Length:954
Mass (Da):104,123
Last modified:June 1, 2003 - v1
Checksum:i06CE72937E173D84
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000032 Genomic DNA. Translation: BAC62144.1.
RefSeqiNP_800311.1. NC_004605.1.

Genome annotation databases

EnsemblBacteriaiBAC62144; BAC62144; BAC62144.
GeneIDi1191490.
KEGGivpa:VPA0801.
PATRICi20145999. VBIVibPar50997_3732.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000032 Genomic DNA. Translation: BAC62144.1 .
RefSeqi NP_800311.1. NC_004605.1.

3D structure databases

ProteinModelPortali Q87I05.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 223926.VPA0801.

Proteomic databases

PRIDEi Q87I05.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC62144 ; BAC62144 ; BAC62144 .
GeneIDi 1191490.
KEGGi vpa:VPA0801.
PATRICi 20145999. VBIVibPar50997_3732.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi IRVQVII.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci VPAR223926:GHK4-4034-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
    Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
    Lancet 361:743-749(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RIMD 2210633.

Entry informationi

Entry nameiGCSP_VIBPA
AccessioniPrimary (citable) accession number: Q87I05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2003
Last modified: October 1, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3