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Q87HX2

- FTHS_VIBPA

UniProt

Q87HX2 - FTHS_VIBPA

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciVPAR223926:GHK4-4067-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:VPA0834
    OrganismiVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
    Taxonomic identifieri223926 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000002493: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 582582Formate--tetrahydrofolate ligasePRO_0000199409Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi223926.VPA0834.

    Structurei

    3D structure databases

    ProteinModelPortaliQ87HX2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiAMTVIMS.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q87HX2-1 [UniParc]FASTAAdd to Basket

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    MQSDIEICRN TPLSSIDVIA EKAGLLPEEF DTHGKYKAKV HPKCLARLND    50
    NQNGKLVLVT AITPTPLGEG KTVTTIGLAQ GLAKLKQSVM ACIRQPSMGP 100
    VFGIKGGAAG GGYSQVAPME ELNLHLTGDI HAVTAAHNLA SAALDARLFH 150
    EQREGYDAFE ARTGLKALKI DVESITWKRV MDHNDRALRM VKIGLNEHGK 200
    TINGFERNEG FDISAASELM AIIALAKNLK DLRQRIGKIV VAYDLDGQPI 250
    TTEDLQVAGA MAVTLKEAIA PTLMQTLEGV PTLIHAGPFA NIAHGNSSII 300
    ADEIALKLSR YTVTEAGFGS DMGFEKACNI KAAAANKAPD CVVIVATLRG 350
    LKANSGHYDL RPGMAIPDSI FSPDQAALVA GFENLKWHIK NVHKYGIPAV 400
    VAINQFPQDC EQELTALQDL IHAFDPNVKV AISTAFAQGG EGTRDLAQYV 450
    VDACEKTTNF RPLYQKHQSL QEKLMSVCEA GYGATNVEMS ELATKQLAHF 500
    EKLGFNELAV CIAKTPLSVT TDSSVKGAPV GFTVPIRELR LCAGAGFVYA 550
    LSGSVMTMPG LPDKPAFMNL DLDEDGNIIG LS 582
    Length:582
    Mass (Da):62,338
    Last modified:June 1, 2003 - v1
    Checksum:iE8D2B79BE66F57D0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000032 Genomic DNA. Translation: BAC62177.1.
    RefSeqiNP_800344.1. NC_004605.1.

    Genome annotation databases

    EnsemblBacteriaiBAC62177; BAC62177; BAC62177.
    GeneIDi1191523.
    KEGGivpa:VPA0834.
    PATRICi20146063. VBIVibPar50997_3764.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000032 Genomic DNA. Translation: BAC62177.1 .
    RefSeqi NP_800344.1. NC_004605.1.

    3D structure databases

    ProteinModelPortali Q87HX2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 223926.VPA0834.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC62177 ; BAC62177 ; BAC62177 .
    GeneIDi 1191523.
    KEGGi vpa:VPA0834.
    PATRICi 20146063. VBIVibPar50997_3764.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi AMTVIMS.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci VPAR223926:GHK4-4067-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
      Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
      Lancet 361:743-749(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RIMD 2210633.

    Entry informationi

    Entry nameiFTHS_VIBPA
    AccessioniPrimary (citable) accession number: Q87HX2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3