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Q87HX2

- FTHS_VIBPA

UniProt

Q87HX2 - FTHS_VIBPA

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, VPA0834
Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVPAR223926:GHK4-4067-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:VPA0834
OrganismiVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Taxonomic identifieri223926 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002493: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 582582Formate--tetrahydrofolate ligaseUniRule annotationPRO_0000199409Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi223926.VPA0834.

Structurei

3D structure databases

ProteinModelPortaliQ87HX2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiAMTVIMS.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q87HX2-1 [UniParc]FASTAAdd to Basket

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MQSDIEICRN TPLSSIDVIA EKAGLLPEEF DTHGKYKAKV HPKCLARLND    50
NQNGKLVLVT AITPTPLGEG KTVTTIGLAQ GLAKLKQSVM ACIRQPSMGP 100
VFGIKGGAAG GGYSQVAPME ELNLHLTGDI HAVTAAHNLA SAALDARLFH 150
EQREGYDAFE ARTGLKALKI DVESITWKRV MDHNDRALRM VKIGLNEHGK 200
TINGFERNEG FDISAASELM AIIALAKNLK DLRQRIGKIV VAYDLDGQPI 250
TTEDLQVAGA MAVTLKEAIA PTLMQTLEGV PTLIHAGPFA NIAHGNSSII 300
ADEIALKLSR YTVTEAGFGS DMGFEKACNI KAAAANKAPD CVVIVATLRG 350
LKANSGHYDL RPGMAIPDSI FSPDQAALVA GFENLKWHIK NVHKYGIPAV 400
VAINQFPQDC EQELTALQDL IHAFDPNVKV AISTAFAQGG EGTRDLAQYV 450
VDACEKTTNF RPLYQKHQSL QEKLMSVCEA GYGATNVEMS ELATKQLAHF 500
EKLGFNELAV CIAKTPLSVT TDSSVKGAPV GFTVPIRELR LCAGAGFVYA 550
LSGSVMTMPG LPDKPAFMNL DLDEDGNIIG LS 582
Length:582
Mass (Da):62,338
Last modified:June 1, 2003 - v1
Checksum:iE8D2B79BE66F57D0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000032 Genomic DNA. Translation: BAC62177.1.
RefSeqiNP_800344.1. NC_004605.1.

Genome annotation databases

EnsemblBacteriaiBAC62177; BAC62177; BAC62177.
GeneIDi1191523.
KEGGivpa:VPA0834.
PATRICi20146063. VBIVibPar50997_3764.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000032 Genomic DNA. Translation: BAC62177.1 .
RefSeqi NP_800344.1. NC_004605.1.

3D structure databases

ProteinModelPortali Q87HX2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 223926.VPA0834.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC62177 ; BAC62177 ; BAC62177 .
GeneIDi 1191523.
KEGGi vpa:VPA0834.
PATRICi 20146063. VBIVibPar50997_3764.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi AMTVIMS.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci VPAR223926:GHK4-4067-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
    Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
    Lancet 361:743-749(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RIMD 2210633.

Entry informationi

Entry nameiFTHS_VIBPA
AccessioniPrimary (citable) accession number: Q87HX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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