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Q87HX2 (FTHS_VIBPA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:VPA0834
OrganismVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) [Complete proteome] [HAMAP]
Taxonomic identifier223926 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length582 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 582582Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199409

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q87HX2 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: E8D2B79BE66F57D0

FASTA58262,338
        10         20         30         40         50         60 
MQSDIEICRN TPLSSIDVIA EKAGLLPEEF DTHGKYKAKV HPKCLARLND NQNGKLVLVT 

        70         80         90        100        110        120 
AITPTPLGEG KTVTTIGLAQ GLAKLKQSVM ACIRQPSMGP VFGIKGGAAG GGYSQVAPME 

       130        140        150        160        170        180 
ELNLHLTGDI HAVTAAHNLA SAALDARLFH EQREGYDAFE ARTGLKALKI DVESITWKRV 

       190        200        210        220        230        240 
MDHNDRALRM VKIGLNEHGK TINGFERNEG FDISAASELM AIIALAKNLK DLRQRIGKIV 

       250        260        270        280        290        300 
VAYDLDGQPI TTEDLQVAGA MAVTLKEAIA PTLMQTLEGV PTLIHAGPFA NIAHGNSSII 

       310        320        330        340        350        360 
ADEIALKLSR YTVTEAGFGS DMGFEKACNI KAAAANKAPD CVVIVATLRG LKANSGHYDL 

       370        380        390        400        410        420 
RPGMAIPDSI FSPDQAALVA GFENLKWHIK NVHKYGIPAV VAINQFPQDC EQELTALQDL 

       430        440        450        460        470        480 
IHAFDPNVKV AISTAFAQGG EGTRDLAQYV VDACEKTTNF RPLYQKHQSL QEKLMSVCEA 

       490        500        510        520        530        540 
GYGATNVEMS ELATKQLAHF EKLGFNELAV CIAKTPLSVT TDSSVKGAPV GFTVPIRELR 

       550        560        570        580 
LCAGAGFVYA LSGSVMTMPG LPDKPAFMNL DLDEDGNIIG LS 

« Hide

References

[1]"Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
Lancet 361:743-749(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RIMD 2210633.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000032 Genomic DNA. Translation: BAC62177.1.
RefSeqNP_800344.1. NC_004605.1.

3D structure databases

ProteinModelPortalQ87HX2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING223926.VPA0834.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC62177; BAC62177; BAC62177.
GeneID1191523.
KEGGvpa:VPA0834.
PATRIC20146063. VBIVibPar50997_3764.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMARIFHERT.
OrthoDBEOG6PCPSP.
ProtClustDBPRK13506.

Enzyme and pathway databases

BioCycVPAR223926:GHK4-4067-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_VIBPA
AccessionPrimary (citable) accession number: Q87HX2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways