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Reviewed, UniProtKB/Swiss-Prot Q87HJ2 (FABH2_VIBPA)

Last modified February 9, 2010. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 2
    EC=2.3.1.180
Alternative name(s):
    3-oxoacyl-[acyl-carrier-protein] synthase III protein 2
    Beta-ketoacyl-ACP synthase III 2
      Short name=KAS III 2
Gene names
Name: fabH2
Ordered Locus Names: VPA0971
OrganismVibrio parahaemolyticus [Complete proteome] [HAMAP]
Taxonomic identifier670 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

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Protein attributes

Sequence length364 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815

Subunit structure

Homodimer By similarity. HAMAP MF_01815

Subcellular location

Cytoplasm Probable HAMAP MF_01815.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/acpP and fabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the fabH family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3643643-oxoacyl-[acyl-carrier-protein] synthase 3 protein 2 HAMAP MF_01815
PRO_0000110505

Regions

Region252 – 2565ACP-binding By similarity

Sites

Active site1131 By similarity
Active site2511 By similarity
Active site2811 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q87HJ2-1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: ACD68181569A3D56

FASTA36439,450
        10         20         30         40         50         60 
MTNYYAEITG WGKCVPPTVL SNDDLSTFLD TSDEWIRTRT GIENRRISHV NTSDMATVAA 

        70         80         90        100        110        120 
QHALARAGVE ASEIDLIIVA TCSPDSLIPN IASKVQQNLG IRSAAAFDLN AACTGFVYGL 

       130        140        150        160        170        180 
ETGTRLIQSG NYRHAIIIGA ERLSFYIDWA MRDTAVLFGD GAGAVILSRT EKETGLLQSQ 

       190        200        210        220        230        240 
IGCDAKGRDI LSVPKFGTCM DRFAEDNGYW DFNFVGQEIF KRAVKGMGLA AKTVLKASQL 

       250        260        270        280        290        300 
TTEQIDVVIP HQANIRIIQT LCDLSGIPQD KAFVNIQNYG NTSAATVPIA LCEAVEQGRV 

       310        320        330        340        350        360 
NPGDNMLLAA FGAGLTWGAA VLKWGDRVTP IGESDAALPE CEQSALELLE RAIKLCNERR 


RDEV

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References

[1]"Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
Lancet 361:743-749(2003) [PubMed: 12620739] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RIMD 2210633 / Serotype O3:K6.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000032 Genomic DNA. Translation: BAC62314.1.
RefSeqNP_800481.1.

3D structure databases

SMRQ87HJ2. Positions 7-324.
ModBaseSearch...

Genome annotation databases

GeneID1191660.
GenomeReviewsGene locus VPA0971 in contig BA000032_GR.
KEGGvpa:VPA0971.
NMPDRfig|223926.1.peg.4051.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG649927.
OMAYIVPHQA.

Enzyme and pathway databases

BioCycVPAR223926:VPA0971-MONOMER.
BRENDA2.3.1.180. 3063.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
TIGRFAMsTIGR00747. fabH. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameFABH2_VIBPA
AccessionPrimary (citable) accession number: Q87HJ2
Entry history
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: June 1, 2003
Last modified: February 9, 2010
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents