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Q87HG4

- ALR2_VIBPA

UniProt

Q87HG4 - ALR2_VIBPA

Protein

Alanine racemase 2

Gene

alr2

Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei76 – 761Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei175 – 1751SubstrateUniRule annotation
    Active sitei301 – 3011Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei349 – 3491Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciVPAR223926:GHK4-4238-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemase 2UniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alr2
    Ordered Locus Names:VPA1001
    OrganismiVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
    Taxonomic identifieri223926 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000002493: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 409409Alanine racemase 2PRO_0000114594Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei76 – 761N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi223926.VPA1001.

    Structurei

    3D structure databases

    ProteinModelPortaliQ87HG4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    HOGENOMiHOG000279190.
    KOiK01775.
    OMAiQQIPCVA.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q87HG4-1 [UniParc]FASTAAdd to Basket

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    MRLKKTLLSI AIAAATFTPA MHSIAAPLQL QATLDQESQI QSSNTWLEID    50
    LGQFKQNIEQ FKSHMNDQTK ICAVMKADAY GNGIAGLMPT IIEQQIPCVA 100
    IASNAEAQVV RDSGFKGQLM RVRSAEIGEI EGALDLNVEE LIGTLDQAKA 150
    IAALSKKANK TVKVHLALND GGMGRNGIDM TTENGKKEAL AIAKQSGVEI 200
    VGIMTHFPNY NAEEVRAKLG SFKESSAWLI KEANLKREDI LLHVANSYTA 250
    LNVPEAQLDM VRPGGVLYGD LPTNLEYPSI VSFKTRVASL HHLPKNSTVG 300
    YDSSFTTTKE SVMANLPVGY SDGYPRKMGN TADVLINGQR AKVVGVTSMN 350
    TTMIDVSDIK GVKPGSEVVL FGNQKSQTIN AAEIEKNADV IFPELYTIWG 400
    TSNPRVYVK 409
    Length:409
    Mass (Da):44,326
    Last modified:June 1, 2003 - v1
    Checksum:i8BF46C9023224E8B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000032 Genomic DNA. Translation: BAC62344.1.
    RefSeqiNP_800511.1. NC_004605.1.

    Genome annotation databases

    EnsemblBacteriaiBAC62344; BAC62344; BAC62344.
    GeneIDi1191694.
    KEGGivpa:VPA1001.
    PATRICi20146405. VBIVibPar50997_3932.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000032 Genomic DNA. Translation: BAC62344.1 .
    RefSeqi NP_800511.1. NC_004605.1.

    3D structure databases

    ProteinModelPortali Q87HG4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 223926.VPA1001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC62344 ; BAC62344 ; BAC62344 .
    GeneIDi 1191694.
    KEGGi vpa:VPA1001.
    PATRICi 20146405. VBIVibPar50997_3932.

    Phylogenomic databases

    eggNOGi COG0787.
    HOGENOMi HOG000279190.
    KOi K01775.
    OMAi QQIPCVA.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci VPAR223926:GHK4-4238-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
      Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
      Lancet 361:743-749(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RIMD 2210633.

    Entry informationi

    Entry nameiALR2_VIBPA
    AccessioniPrimary (citable) accession number: Q87HG4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 15, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3