Q87H53 (Q87H53_VIBPA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Choline dehydrogenase HAMAP MF_00750
Short name=CDH HAMAP MF_00750
Short name=CHD HAMAP MF_00750
EC=1.1.99.1 HAMAP MF_00750

Gene names

Name:	betA HAMAP MF_00750
Ordered Locus Names:	VPA1112

Organism

Vibrio parahaemolyticus [Complete proteome] [HAMAP]

Taxonomic identifier

670 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	581 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity. HAMAP MF_00750 SAAS SAAS007867
Catalytic activity	Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP MF_00750 RuleBase RU003969 SAAS SAAS007867
Cofactor	FAD By similarity. HAMAP MF_00750 SAAS SAAS007867 RuleBase RU003968
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP MF_00750 RuleBase RU003969 SAAS SAAS007867
Sequence similarities	Belongs to the GMC oxidoreductase family. HAMAP MF_00750 RuleBase RU003968

Ontologies

Keywords
Ligand	FAD HAMAP MF_00750 SAAS SAAS011533 Flavoprotein HAMAP MF_00750 SAAS SAAS011533 RuleBase RU003968
Molecular function	Oxidoreductase HAMAP MF_00750 SAAS SAAS007867
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP
Molecular function	choline dehydrogenase activity Inferred from electronic annotation. Source: HAMAP flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	6 – 35	30	FAD By similarity HAMAP MF_00750
Sites
	Active site	485	1	By similarity HAMAP MF_00750

Sequences

	Sequence		Length	Mass (Da)
	Q87H53 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: CAD4A2A7EBFEFBF2	FASTA	581	64,392
	10 20 30 40 50 60 MKQHYDYIIV GAGSAGCVLA DRLTESGQHS VLLLEAGGTD KSIFIQMPTA LSYPMNTEKY 70 80 90 100 110 120 AWQFETVQED GLDGRQLHCP RGKVLGGSSS INGMVYVRGH ACDFDQWEEE GAKGWNYQAC 130 140 150 160 170 180 LPYFRKAESW VGGADDYRGD SGPLGTCSGN DMKLNPLYEA FIEAGKEAGY PETDDYNGFQ 190 200 210 220 230 240 QEGFGPMHMT VDKGVRASTS NAYLSRAKKR KNFTLMKRVT VRRVLLEEAG SDEKGLEETG 250 260 270 280 290 300 LQGKKAVGVE FEKAGSIQQC FAKNEVISSA GSIGSVQLLQ LSGIGPKDVL EKAGIELKHQ 310 320 330 340 350 360 LEGVGKNLQD HLEVYFQYHC KQPITLNSKL GLVSKGLIGT EWILTRKGLG ATNHFESCAF 370 380 390 400 410 420 IRSREGLKWP NIQYHFLPAA MRYDGQAAFD GHGFQVHVGP NKPESRGSVE VVSSNPNDKP 430 440 450 460 470 480 KIEFNYISTE QDKQDWRDCI RLTREILNQP AMDEFRGDEI QPGLHITTDE QIDEWVKQNV 490 500 510 520 530 540 ESAYHPSCSC KMGADDDPLA VLDEQCQVRG IQGLRVVDSS IFPTIPNGNL NAPTIMVAER 550 560 570 580 AADMILGNAL EKANNTPVWI APNWQEMQRM HPPKRDLESI S

References

[1]

"Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae." Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T. Lancet 361:743-749(2003) [PubMed: 12620739] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RIMD 2210633 / Serotype O3:K6.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000032 Genomic DNA. Translation: BAC62455.1.
RefSeq	NP_800622.1. NC_004605.1.
3D structure databases
ProteinModelPortal	Q87H53.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1191808.
GenomeReviews	Gene locus VPA1112 in contig BA000032_GR.
KEGG	vpa:VPA1112.
NMPDR	fig|223926.1.peg.4192.
PATRIC	20146623. VBIVibPar50997_4038.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG734713.
OMA	HMTVKNG.
ProtClustDB	PRK02106.
Enzyme and pathway databases
BioCyc	VPAR223926:VPA1112-MONOMER.
Family and domain databases
HAMAP	MF_00750. Choline_dehydrogen. [Tree]
InterPro	IPR011533. Choline_dehydrogenase. IPR012132. GMC_OxRdtase. IPR000172. GMC_OxRdtase_N. IPR007867. GMC_OxRtase_C. [Graphical view]
KO	K00108.
Pfam	PF05199. GMC_oxred_C. 1 hit. PF00732. GMC_oxred_N. 1 hit. [Graphical view]
PIRSF	PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMs	TIGR01810. BetA. 1 hit.
PROSITE	PS00623. GMC_OXRED_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q87H53_VIBPA

Accession

Primary (citable) accession number: Q87H53

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	December 14, 2011
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)