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Q87H52

- BETB_VIBPA

UniProt

Q87H52 - BETB_VIBPA

Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase

Gene

betB

Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    • Comment

    Functioni

    Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.UniRule annotation

    Catalytic activityi

    Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

    Cofactori

    Binds 2 potassium ions per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi23 – 231Potassium 1UniRule annotation
    Metal bindingi90 – 901Potassium 1UniRule annotation
    Active sitei159 – 1591Charge relay systemUniRule annotation
    Metal bindingi241 – 2411Potassium 2; via carbonyl oxygenUniRule annotation
    Active sitei247 – 2471Proton acceptorUniRule annotation
    Binding sitei281 – 2811NAD/NADPUniRule annotation
    Binding sitei382 – 3821NAD/NADPUniRule annotation
    Metal bindingi452 – 4521Potassium 2; via carbonyl oxygenUniRule annotation
    Metal bindingi455 – 4551Potassium 2; via carbonyl oxygenUniRule annotation
    Active sitei459 – 4591Charge relay systemUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi147 – 1504NAD/NADPUniRule annotation
    Nucleotide bindingi173 – 1764NAD/NADPUniRule annotation
    Nucleotide bindingi225 – 2306NAD/NADPUniRule annotation

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Metal-binding, NAD, NADP, Potassium

    Enzyme and pathway databases

    BioCyciVPAR223926:GHK4-4353-MONOMER.
    UniPathwayiUPA00529; UER00386.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
    Short name:
    BADHUniRule annotation
    Gene namesi
    Name:betBUniRule annotation
    Ordered Locus Names:VPA1113
    OrganismiVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
    Taxonomic identifieri223926 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000002493: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 486486NAD/NADP-dependent betaine aldehyde dehydrogenasePRO_0000056555Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei281 – 2811Cysteine sulfenic acid (-SOH)UniRule annotation

    Keywords - PTMi

    Oxidation

    Interactioni

    Subunit structurei

    Dimer of dimers.UniRule annotation

    Protein-protein interaction databases

    STRINGi223926.VPA1113.

    Structurei

    3D structure databases

    ProteinModelPortaliQ87H52.
    SMRiQ87H52. Positions 5-485.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271505.
    KOiK00130.
    OMAiRANDTTM.
    OrthoDBiEOG6BS8QW.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    HAMAPiMF_00804. BADH.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR011264. BADH.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR01804. BADH. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q87H52-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEMKTHYIDG AMYIGCSEEH FTTYNPANGE PLANIKQANQ SDMEAAIESA    50
    KRGFEVWSAM TAIERSRILN KAVAILRERN DELAALEVAD TGKPIQEAIA 100
    VDITTGADVI EYYAGLAPSL QGEQQPLNEN QFFYTRREPL GICAGIGAWN 150
    YPIQIAMWKS APALAAGNAM IFKPSEETPL TALKLAEIYS EAGLPDGVFN 200
    VVQGDYRVGQ MLTAHPDIAK VSFTGESGTG KVVMGDSAKT LKQVTMELGG 250
    KSPLIVFDDA KLDDAVSAAM VANFYTQGEV CTNGTRVFVH ESIYDDFVAQ 300
    LKTRTEKLVV GDPLDENTQI GALISKEHES KVLSAIESAK ASGATLLTGG 350
    YKVTDNGLQN GNFVAPTVFI DCDDSMSHVQ QEIFGPVMSV LKFSEEAEVI 400
    ERANDTDYGL AAGVFTQNLS RAHRVIHKIQ AGICWVNAWG DSPAEMPVGG 450
    YKQSGIGREN GVETLKHYTQ TKSVLVQLSD FESPYA 486
    Length:486
    Mass (Da):52,618
    Last modified:June 1, 2003 - v1
    Checksum:i1ECBF4B227E4C265
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000032 Genomic DNA. Translation: BAC62456.1.
    RefSeqiNP_800623.1. NC_004605.1.

    Genome annotation databases

    EnsemblBacteriaiBAC62456; BAC62456; BAC62456.
    GeneIDi1191809.
    KEGGivpa:VPA1113.
    PATRICi20146625. VBIVibPar50997_4039.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000032 Genomic DNA. Translation: BAC62456.1 .
    RefSeqi NP_800623.1. NC_004605.1.

    3D structure databases

    ProteinModelPortali Q87H52.
    SMRi Q87H52. Positions 5-485.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 223926.VPA1113.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC62456 ; BAC62456 ; BAC62456 .
    GeneIDi 1191809.
    KEGGi vpa:VPA1113.
    PATRICi 20146625. VBIVibPar50997_4039.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271505.
    KOi K00130.
    OMAi RANDTTM.
    OrthoDBi EOG6BS8QW.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00386 .
    BioCyci VPAR223926:GHK4-4353-MONOMER.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    HAMAPi MF_00804. BADH.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR011264. BADH.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR01804. BADH. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
      Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
      Lancet 361:743-749(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RIMD 2210633.

    Entry informationi

    Entry nameiBETB_VIBPA
    AccessioniPrimary (citable) accession number: Q87H52
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3