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Q87H52 (BETB_VIBPA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betB
Ordered Locus Names:VPA1113
OrganismVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) [Complete proteome] [HAMAP]
Taxonomic identifier223926 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio ›

Protein attributes

Sequence length486 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00804

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP-Rule MF_00804

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycine betaine biosynthetic process from choline

Inferred from electronic annotation. Source: HAMAP

   Molecular_functionbetaine-aldehyde dehydrogenase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 486486Betaine aldehyde dehydrogenase HAMAP-Rule MF_00804
PRO_0000056555

Regions

Nucleotide binding225 – 2306NAD By similarity

Sites

Active site2471 By similarity
Active site2811 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q87H52 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 1ECBF4B227E4C265

FASTA48652,618
        10         20         30         40         50         60 
MEMKTHYIDG AMYIGCSEEH FTTYNPANGE PLANIKQANQ SDMEAAIESA KRGFEVWSAM 

        70         80         90        100        110        120 
TAIERSRILN KAVAILRERN DELAALEVAD TGKPIQEAIA VDITTGADVI EYYAGLAPSL 

       130        140        150        160        170        180 
QGEQQPLNEN QFFYTRREPL GICAGIGAWN YPIQIAMWKS APALAAGNAM IFKPSEETPL 

       190        200        210        220        230        240 
TALKLAEIYS EAGLPDGVFN VVQGDYRVGQ MLTAHPDIAK VSFTGESGTG KVVMGDSAKT 

       250        260        270        280        290        300 
LKQVTMELGG KSPLIVFDDA KLDDAVSAAM VANFYTQGEV CTNGTRVFVH ESIYDDFVAQ 

       310        320        330        340        350        360 
LKTRTEKLVV GDPLDENTQI GALISKEHES KVLSAIESAK ASGATLLTGG YKVTDNGLQN 

       370        380        390        400        410        420 
GNFVAPTVFI DCDDSMSHVQ QEIFGPVMSV LKFSEEAEVI ERANDTDYGL AAGVFTQNLS 

       430        440        450        460        470        480 
RAHRVIHKIQ AGICWVNAWG DSPAEMPVGG YKQSGIGREN GVETLKHYTQ TKSVLVQLSD 


FESPYA

« Hide

References

[1]"Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
Lancet 361:743-749(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RIMD 2210633.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000032 Genomic DNA. Translation: BAC62456.1.
RefSeqNP_800623.1. NC_004605.1.

3D structure databases

ProteinModelPortalQ87H52.
SMRQ87H52. Positions 5-485.
ModBaseSearch...

Protein-protein interaction databases

STRING223926.VPA1113.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC62456; BAC62456; BAC62456.
GeneID1191809.
KEGGvpa:VPA1113.
PATRIC20146625. VBIVibPar50997_4039.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271505.
KOK00130.
OMASKEHESK.
ProtClustDBPRK13252.

Enzyme and pathway databases

UniPathwayUPA00529; UER00386.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPMF_00804. BADH.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. Betaine_Ald_DH.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR01804. BADH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETB_VIBPA
AccessionPrimary (citable) accession number: Q87H52
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: June 1, 2003
Last modified: May 1, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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