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Q87H52

- BETB_VIBPA

UniProt

Q87H52 - BETB_VIBPA

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Protein
NAD/NADP-dependent betaine aldehyde dehydrogenase
Gene
betB, VPA1113
Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid By similarity.UniRule annotation

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

Binds 2 potassium ions per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi23 – 231Potassium 1 By similarity
Metal bindingi90 – 901Potassium 1 By similarity
Active sitei159 – 1591Charge relay system By similarity
Metal bindingi241 – 2411Potassium 2; via carbonyl oxygen By similarity
Active sitei247 – 2471Proton acceptor By similarity
Binding sitei281 – 2811NAD/NADP By similarity
Binding sitei382 – 3821NAD/NADP By similarity
Metal bindingi452 – 4521Potassium 2; via carbonyl oxygen By similarity
Metal bindingi455 – 4551Potassium 2; via carbonyl oxygen By similarity
Active sitei459 – 4591Charge relay system By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi147 – 1504NAD/NADP By similarity
Nucleotide bindingi173 – 1764NAD/NADP By similarity
Nucleotide bindingi225 – 2306NAD/NADP By similarity

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, NADP, Potassium

Enzyme and pathway databases

BioCyciVPAR223926:GHK4-4353-MONOMER.
UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betB
Ordered Locus Names:VPA1113
OrganismiVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Taxonomic identifieri223926 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002493: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation
PRO_0000056555Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei281 – 2811Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Dimer of dimers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi223926.VPA1113.

Structurei

3D structure databases

ProteinModelPortaliQ87H52.
SMRiQ87H52. Positions 5-485.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00130.
OMAiRANDTTM.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00804. BADH.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01804. BADH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q87H52-1 [UniParc]FASTAAdd to Basket

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MEMKTHYIDG AMYIGCSEEH FTTYNPANGE PLANIKQANQ SDMEAAIESA    50
KRGFEVWSAM TAIERSRILN KAVAILRERN DELAALEVAD TGKPIQEAIA 100
VDITTGADVI EYYAGLAPSL QGEQQPLNEN QFFYTRREPL GICAGIGAWN 150
YPIQIAMWKS APALAAGNAM IFKPSEETPL TALKLAEIYS EAGLPDGVFN 200
VVQGDYRVGQ MLTAHPDIAK VSFTGESGTG KVVMGDSAKT LKQVTMELGG 250
KSPLIVFDDA KLDDAVSAAM VANFYTQGEV CTNGTRVFVH ESIYDDFVAQ 300
LKTRTEKLVV GDPLDENTQI GALISKEHES KVLSAIESAK ASGATLLTGG 350
YKVTDNGLQN GNFVAPTVFI DCDDSMSHVQ QEIFGPVMSV LKFSEEAEVI 400
ERANDTDYGL AAGVFTQNLS RAHRVIHKIQ AGICWVNAWG DSPAEMPVGG 450
YKQSGIGREN GVETLKHYTQ TKSVLVQLSD FESPYA 486
Length:486
Mass (Da):52,618
Last modified:June 1, 2003 - v1
Checksum:i1ECBF4B227E4C265
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000032 Genomic DNA. Translation: BAC62456.1.
RefSeqiNP_800623.1. NC_004605.1.

Genome annotation databases

EnsemblBacteriaiBAC62456; BAC62456; BAC62456.
GeneIDi1191809.
KEGGivpa:VPA1113.
PATRICi20146625. VBIVibPar50997_4039.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000032 Genomic DNA. Translation: BAC62456.1 .
RefSeqi NP_800623.1. NC_004605.1.

3D structure databases

ProteinModelPortali Q87H52.
SMRi Q87H52. Positions 5-485.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 223926.VPA1113.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC62456 ; BAC62456 ; BAC62456 .
GeneIDi 1191809.
KEGGi vpa:VPA1113.
PATRICi 20146625. VBIVibPar50997_4039.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
KOi K00130.
OMAi RANDTTM.
OrthoDBi EOG6BS8QW.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00386 .
BioCyci VPAR223926:GHK4-4353-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPi MF_00804. BADH.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR01804. BADH. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
    Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
    Lancet 361:743-749(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RIMD 2210633.

Entry informationi

Entry nameiBETB_VIBPA
AccessioniPrimary (citable) accession number: Q87H52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: June 1, 2003
Last modified: June 11, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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