Q87GM3 (ADE_VIBPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenine deaminase
Short name=ADE
EC=3.5.4.2

Alternative name(s):
Adenine aminohydrolase
Short name=AAH

Gene names

Ordered Locus Names:

VPA1292

Organism

Vibrio parahaemolyticus [Complete proteome] [HAMAP]

Taxonomic identifier

670 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism By similarity. HAMAP MF_01962
Catalytic activity	Adenine + H2O = hypoxanthine + NH3. HAMAP MF_01962
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_01962
Sequence similarities	Belongs to the adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	adenine deaminase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Adenine deaminase HAMAP MF_01962		PRO_0000194399
Sites
	Active site	197	1	Proton donor By similarity
	Metal binding	14	1	Zinc; catalytic By similarity
	Metal binding	16	1	Zinc; catalytic By similarity
	Metal binding	194	1	Zinc; catalytic By similarity
	Metal binding	275	1	Zinc; catalytic By similarity
	Binding site	276	1	Substrate By similarity
	Site	218	1	Important for catalytic activity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q87GM3 [UniParc]. Last modified May 30, 2003. Version 1. Checksum: FC6A2B523742F3BF	FASTA	337	37,998
	10 20 30 40 50 60 MNAFIQGLPK VELHLHIEGS LEPELMFKLA KRNGIDIPYS SPSELREAYQ FEDLQSFLDL 70 80 90 100 110 120 YYQGANVLRT EQDFYDLTWE YLEHCKADNV IHTEIFFDPQ THTERGIDFD TVLNGISRAL 130 140 150 160 170 180 TDGREKLGIT SQIIACFLRH LSEESAMETL QSVLKHRDKI IGVGLDSSEK GHPPAKFLRV 190 200 210 220 230 240 FQQAKEAGLL TVAHAGEEGP AQNITDAIEM LEVSRVDHGV RCVEDEALVG SLIETKMPLT 250 260 270 280 290 300 VCPLSNIKLC VFDEMGQHNI VELLRKGVAV TINSDDPVYF GGYMTDNFLA VNQAHPMIKE 310 320 330 ELAKFTLNAI DASFIDNELK AQYRHKVEQY VAQHSSM

References

[1]

"Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae." Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T. Lancet 361:743-749(2003) [PubMed: 12620739] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RIMD 2210633 / Serotype O3:K6.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000032 Genomic DNA. Translation: BAC62635.1.
RefSeq	NP_800802.1. NC_004605.1.
3D structure databases
ProteinModelPortal	Q87GM3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1191988.
GenomeReviews	Gene locus VPA1292 in contig BA000032_GR.
KEGG	vpa:VPA1292.
NMPDR	fig|223926.1.peg.4372.
PATRIC	20146983. VBIVibPar50997_4218.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG630382.
OMA	ENFHALY.
ProtClustDB	PRK09358.
Enzyme and pathway databases
BioCyc	VPAR223926:VPA1292-MONOMER.
Family and domain databases
HAMAP	MF_01962. Adenine_deaminase. [Tree]
InterPro	IPR001365. A/AMP_deaminase_dom. IPR006330. A_deaminase. [Graphical view]
KO	K01488.
PANTHER	PTHR11409:SF21. PTHR11409:SF21. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. Aden_deam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ADE_VIBPA

Accession

Primary (citable) accession number: Q87GM3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2003
Last sequence update:	May 30, 2003
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program