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Protein

L-lactate dehydrogenase

Gene

lldD

Organism
Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain.UniRule annotation

Catalytic activityi

(S)-lactate + an oxidized electron acceptor = pyruvate + a reduced electron acceptor.UniRule annotation

Cofactori

FMNUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei24SubstrateUniRule annotation1
Binding sitei106FMNUniRule annotation1
Binding sitei127FMNUniRule annotation1
Binding sitei129SubstrateUniRule annotation1
Binding sitei155FMNUniRule annotation1
Binding sitei164SubstrateUniRule annotation1
Binding sitei251FMNUniRule annotation1
Active sitei275Proton acceptorUniRule annotation1
Binding sitei278SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi306 – 330FMNUniRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFlavoprotein, FMN

Enzyme and pathway databases

BioCyciVPAR223926:G1GTB-4738-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.-.-UniRule annotation)
Gene namesi
Name:lldDUniRule annotation
Ordered Locus Names:VPA1499
OrganismiVibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
Taxonomic identifieri223926 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000002493 Componenti: Chromosome 2

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002063531 – 379L-lactate dehydrogenaseAdd BLAST379

Proteomic databases

PRIDEiQ87G18

Interactioni

Protein-protein interaction databases

STRINGi223926.VPA1499

Structurei

3D structure databases

ProteinModelPortaliQ87G18
SMRiQ87G18
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 379FMN hydroxy acid dehydrogenaseUniRule annotationAdd BLAST379

Sequence similaritiesi

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DMF Bacteria
COG1304 LUCA
HOGENOMiHOG000217464
KOiK00101
OMAiDTPGFFQ

Family and domain databases

CDDicd02809 alpha_hydroxyacid_oxid_FMN, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01559 L_lact_dehydr, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR012133 Alpha-hydoxy_acid_DH_FMN
IPR000262 FMN-dep_DH
IPR037396 FMN_HAD
IPR008259 FMN_hydac_DH_AS
IPR020920 LldD
PfamiView protein in Pfam
PF01070 FMN_dh, 1 hit
PIRSFiPIRSF000138 Al-hdrx_acd_dh, 1 hit
PROSITEiView protein in PROSITE
PS00557 FMN_HYDROXY_ACID_DH_1, 1 hit
PS51349 FMN_HYDROXY_ACID_DH_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q87G18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIISASTDYR AAAKAKLPPF LFHYIDGGSY DERTLKRNTD DLGDVALRQR
60 70 80 90 100
VLRDMTDLSL ETEIFGEKLA MPIALAPVGL TGMYARRGEV QAAKAAEKKG
110 120 130 140 150
IPFTMSTVSV CPIEEVAPAI ERPMWFQLYV LKDRGFMKNV LERAKAAGVT
160 170 180 190 200
TLVFTVDMPV PGARYRDMHS GMSGPNAAMR RVFQAMRHPS WALDVGLLGK
210 220 230 240 250
PHDLGNISTY RGEPTKLEDY IGWLGANFDP SISWKDLEWI RDFWDGPMVI
260 270 280 290 300
KGILDEEDAK DAVRFGADGI VVSNHGGRQL DGVLSTAKAL PSIADAVKGD
310 320 330 340 350
LKIFVDSGIR TGLDVVRMLA LGADCTLLGR SFVYALAAQG GAGVENLLDL
360 370
YDKEMRVAMT LTGAKTIADL SRDSLVKIP
Length:379
Mass (Da):41,400
Last modified:June 1, 2003 - v1
Checksum:iF0D02D3D9BC0E390
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000032 Genomic DNA Translation: BAC62842.1
RefSeqiNP_801009.1, NC_004605.1
WP_005478054.1, NC_004605.1

Genome annotation databases

EnsemblBacteriaiBAC62842; BAC62842; BAC62842
GeneIDi1192195
KEGGivpa:VPA1499
PATRICifig|223926.6.peg.4424

Similar proteinsi

Entry informationi

Entry nameiLLDD_VIBPA
AccessioniPrimary (citable) accession number: Q87G18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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