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Reviewed, UniProtKB/Swiss-Prot Q87G18 (LLDD_VIBPA)

Last modified January 19, 2010. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    L-lactate dehydrogenase [cytochrome]
    EC=1.1.2.3
Gene names
Name: lldD
Ordered Locus Names: VPA1499
OrganismVibrio parahaemolyticus [Complete proteome] [HAMAP]
Taxonomic identifier670 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

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Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

(S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H+. HAMAP MF_01559

Cofactor

FMN By similarity. HAMAP MF_01559

Sequence similarities

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

Contains 1 FMN hydroxy acid dehydrogenase domain.

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Ontologies

Keywords
   LigandFMN
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processlactate metabolic process

Inferred from electronic annotation. Source: InterPro

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionFMN binding

Inferred from electronic annotation. Source: InterPro

L-lactate dehydrogenase (cytochrome) activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 379379L-lactate dehydrogenase [cytochrome] HAMAP MF_01559
PRO_0000206353

Regions

Domain1 – 379379FMN hydroxy acid dehydrogenase
Nucleotide binding306 – 33025FMN By similarity

Sites

Active site2751Proton acceptor By similarity
Binding site241Substrate Potential
Binding site1061FMN By similarity
Binding site1271FMN By similarity
Binding site1291Substrate By similarity
Binding site1551FMN By similarity
Binding site1641Substrate By similarity
Binding site2511FMN By similarity
Binding site2781Substrate Potential

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Sequences

Sequence LengthMass (Da)Tools
Q87G18-1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: F0D02D3D9BC0E390

FASTA37941,400
        10         20         30         40         50         60 
MIISASTDYR AAAKAKLPPF LFHYIDGGSY DERTLKRNTD DLGDVALRQR VLRDMTDLSL 

        70         80         90        100        110        120 
ETEIFGEKLA MPIALAPVGL TGMYARRGEV QAAKAAEKKG IPFTMSTVSV CPIEEVAPAI 

       130        140        150        160        170        180 
ERPMWFQLYV LKDRGFMKNV LERAKAAGVT TLVFTVDMPV PGARYRDMHS GMSGPNAAMR 

       190        200        210        220        230        240 
RVFQAMRHPS WALDVGLLGK PHDLGNISTY RGEPTKLEDY IGWLGANFDP SISWKDLEWI 

       250        260        270        280        290        300 
RDFWDGPMVI KGILDEEDAK DAVRFGADGI VVSNHGGRQL DGVLSTAKAL PSIADAVKGD 

       310        320        330        340        350        360 
LKIFVDSGIR TGLDVVRMLA LGADCTLLGR SFVYALAAQG GAGVENLLDL YDKEMRVAMT 

       370 
LTGAKTIADL SRDSLVKIP

« Hide

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References

[1]"Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae."
Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.
Lancet 361:743-749(2003) [PubMed: 12620739] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RIMD 2210633 / Serotype O3:K6.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000032 Genomic DNA. Translation: BAC62842.1.
RefSeqNP_801009.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID1192195.
GenomeReviewsGene locus VPA1499 in contig BA000032_GR.
KEGGvpa:VPA1499.
NMPDRfig|223926.1.peg.4579.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG517781.
OMAWIREFWE.

Enzyme and pathway databases

BioCycVPAR223926:VPA1499-MONOMER.
BRENDA1.1.2.3. 3063.

Family and domain databases

HAMAPMF_01559. L-lact_dehydr.
[Tree]
InterProIPR012133. a-Hydoxy_acid_DH_FMN.
IPR013785. Aldolase_TIM.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
IPR020920. L-lactate_DHase_cyt.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PfamPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameLLDD_VIBPA
AccessionPrimary (citable) accession number: Q87G18
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 1, 2003
Last modified: January 19, 2010
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents