Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q87F49

- DAPE_XYLFT

UniProt

Q87F49 - DAPE_XYLFT

Protein

Succinyl-diaminopimelate desuccinylase

Gene

dapE

Organism
Xylella fastidiosa (strain Temecula1 / ATCC 700964)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.UniRule annotation

    Catalytic activityi

    N-succinyl-LL-2,6-diaminoheptanedioate + H2O = succinate + LL-2,6-diaminoheptanedioate.UniRule annotation

    Cofactori

    Binds 1 Zn2+ ion per subunit.UniRule annotation
    Binds 1 Co2+ ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi66 – 661Cobalt or zinc 1UniRule annotation
    Active sitei68 – 681UniRule annotation
    Metal bindingi99 – 991Cobalt or zinc 1UniRule annotation
    Metal bindingi99 – 991Cobalt or zinc 2UniRule annotation
    Active sitei133 – 1331Proton acceptorUniRule annotation
    Metal bindingi134 – 1341Cobalt or zinc 2UniRule annotation
    Metal bindingi162 – 1621Cobalt or zinc 1UniRule annotation
    Metal bindingi348 – 3481Cobalt or zinc 2UniRule annotation

    GO - Molecular functioni

    1. cobalt ion binding Source: UniProtKB-HAMAP
    2. metallopeptidase activity Source: InterPro
    3. succinyl-diaminopimelate desuccinylase activity Source: UniProtKB-HAMAP
    4. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. diaminopimelate biosynthetic process Source: UniProtKB-HAMAP
    2. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Amino-acid biosynthesis, Diaminopimelate biosynthesis, Lysine biosynthesis

    Keywords - Ligandi

    Cobalt, Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciXFAS183190:GIX4-88-MONOMER.
    UniPathwayiUPA00034; UER00021.

    Protein family/group databases

    MEROPSiM20.010.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinyl-diaminopimelate desuccinylaseUniRule annotation (EC:3.5.1.18UniRule annotation)
    Short name:
    SDAP desuccinylaseUniRule annotation
    Alternative name(s):
    N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolaseUniRule annotation
    Gene namesi
    Name:dapEUniRule annotation
    Ordered Locus Names:PD_0088
    OrganismiXylella fastidiosa (strain Temecula1 / ATCC 700964)
    Taxonomic identifieri183190 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella
    ProteomesiUP000002516: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 377377Succinyl-diaminopimelate desuccinylasePRO_0000375792Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi183190.PD0088.

    Structurei

    3D structure databases

    ProteinModelPortaliQ87F49.
    SMRiQ87F49. Positions 2-374.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M20A family. DapE subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0624.
    KOiK01439.
    OMAiLNSTIHK.
    OrthoDBiEOG60651W.

    Family and domain databases

    Gene3Di3.30.70.360. 1 hit.
    HAMAPiMF_01690. DapE.
    InterProiIPR001261. ArgE/DapE_CS.
    IPR005941. DapE_proteobac.
    IPR002933. Peptidase_M20.
    IPR011650. Peptidase_M20_dimer.
    [Graphical view]
    PfamiPF07687. M20_dimer. 1 hit.
    PF01546. Peptidase_M20. 1 hit.
    [Graphical view]
    SUPFAMiSSF55031. SSF55031. 1 hit.
    TIGRFAMsiTIGR01246. dapE_proteo. 1 hit.
    PROSITEiPS00759. ARGE_DAPE_CPG2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q87F49-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDVLDLACD LISRPSMTPD DAGCQEMIAK RLERAGFICE HLRYAAVSNL    50
    WATHGRGAPV LVLLGHTDVV PPGPVEAWTS DPFMPDMRNG ILYGRGAADM 100
    KGSVAAFVIA AERFLAAYPQ HPGTLAILLT SDEEGQAIDG VRKVAETLRQ 150
    RGQGIDWCLT GEPSSSKRLG DLLRVGRRGS LSATLHVKGV QGHVAYPHQA 200
    RNPIHLALPA FAALTARHWD DGYESFPSTS LQISNIHAGT GANNVIPGAL 250
    EVAFNLRYNP HWIAPRLESE IVALLDQHGL DYTLHWHRSG EPFYTPEGKL 300
    RRIAREVLER FSGAPPEEST GGGTSDARFI APLGAQCIEV GPVNASIHQV 350
    DEHVCLSDLE ALPDLYQLLI ERLLAEH 377
    Length:377
    Mass (Da):40,992
    Last modified:June 1, 2003 - v1
    Checksum:i7269AD1D6B67C98F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009442 Genomic DNA. Translation: AAO27988.1.
    RefSeqiNP_778339.1. NC_004556.1.

    Genome annotation databases

    EnsemblBacteriaiAAO27988; AAO27988; PD_0088.
    GeneIDi1144300.
    KEGGixft:PD0088.
    PATRICi24147572. VBIXylFas71109_0122.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009442 Genomic DNA. Translation: AAO27988.1 .
    RefSeqi NP_778339.1. NC_004556.1.

    3D structure databases

    ProteinModelPortali Q87F49.
    SMRi Q87F49. Positions 2-374.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 183190.PD0088.

    Protein family/group databases

    MEROPSi M20.010.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO27988 ; AAO27988 ; PD_0088 .
    GeneIDi 1144300.
    KEGGi xft:PD0088.
    PATRICi 24147572. VBIXylFas71109_0122.

    Phylogenomic databases

    eggNOGi COG0624.
    KOi K01439.
    OMAi LNSTIHK.
    OrthoDBi EOG60651W.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00021 .
    BioCyci XFAS183190:GIX4-88-MONOMER.

    Family and domain databases

    Gene3Di 3.30.70.360. 1 hit.
    HAMAPi MF_01690. DapE.
    InterProi IPR001261. ArgE/DapE_CS.
    IPR005941. DapE_proteobac.
    IPR002933. Peptidase_M20.
    IPR011650. Peptidase_M20_dimer.
    [Graphical view ]
    Pfami PF07687. M20_dimer. 1 hit.
    PF01546. Peptidase_M20. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55031. SSF55031. 1 hit.
    TIGRFAMsi TIGR01246. dapE_proteo. 1 hit.
    PROSITEi PS00759. ARGE_DAPE_CPG2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative analyses of the complete genome sequences of Pierce's disease and citrus variegated chlorosis strains of Xylella fastidiosa."
      Van Sluys M.A., de Oliveira M.C., Monteiro-Vitorello C.B., Miyaki C.Y., Furlan L.R., Camargo L.E.A., da Silva A.C.R., Moon D.H., Takita M.A., Lemos E.G.M., Machado M.A., Ferro M.I.T., da Silva F.R., Goldman M.H.S., Goldman G.H., Lemos M.V.F., El-Dorry H., Tsai S.M.
      , Carrer H., Carraro D.M., de Oliveira R.C., Nunes L.R., Siqueira W.J., Coutinho L.L., Kimura E.T., Ferro E.S., Harakava R., Kuramae E.E., Marino C.L., Giglioti E., Abreu I.L., Alves L.M.C., do Amaral A.M., Baia G.S., Blanco S.R., Brito M.S., Cannavan F.S., Celestino A.V., da Cunha A.F., Fenille R.C., Ferro J.A., Formighieri E.F., Kishi L.T., Leoni S.G., Oliveira A.R., Rosa V.E. Jr., Sassaki F.T., Sena J.A.D., de Souza A.A., Truffi D., Tsukumo F., Yanai G.M., Zaros L.G., Civerolo E.L., Simpson A.J.G., Almeida N.F. Jr., Setubal J.C., Kitajima J.P.
      J. Bacteriol. 185:1018-1026(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Temecula1 / ATCC 700964.

    Entry informationi

    Entry nameiDAPE_XYLFT
    AccessioniPrimary (citable) accession number: Q87F49
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 26, 2009
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3