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Q87F49 (DAPE_XYLFT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Succinyl-diaminopimelate desuccinylase

Short name=SDAP desuccinylase
EC=3.5.1.18
Alternative name(s):
N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase
Gene names
Name:dapE
Ordered Locus Names:PD_0088
OrganismXylella fastidiosa (strain Temecula1 / ATCC 700964) [Complete proteome] [HAMAP]
Taxonomic identifier183190 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls By similarity. HAMAP-Rule MF_01690

Catalytic activity

N-succinyl-LL-2,6-diaminoheptanedioate + H2O = succinate + LL-2,6-diaminoheptanedioate. HAMAP-Rule MF_01690

Cofactor

Binds 1 Zn2+ ion per subunit By similarity. HAMAP-Rule MF_01690

Binds 1 Co2+ ion per subunit By similarity. HAMAP-Rule MF_01690

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 3/3. HAMAP-Rule MF_01690

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01690

Sequence similarities

Belongs to the peptidase M20A family. DapE subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 377377Succinyl-diaminopimelate desuccinylase HAMAP-Rule MF_01690
PRO_0000375792

Sites

Active site681 By similarity
Active site1331Proton acceptor By similarity
Metal binding661Cobalt or zinc 1 By similarity
Metal binding991Cobalt or zinc 1 By similarity
Metal binding991Cobalt or zinc 2 By similarity
Metal binding1341Cobalt or zinc 2 By similarity
Metal binding1621Cobalt or zinc 1 By similarity
Metal binding3481Cobalt or zinc 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q87F49 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 7269AD1D6B67C98F

FASTA37740,992
        10         20         30         40         50         60 
MSDVLDLACD LISRPSMTPD DAGCQEMIAK RLERAGFICE HLRYAAVSNL WATHGRGAPV 

        70         80         90        100        110        120 
LVLLGHTDVV PPGPVEAWTS DPFMPDMRNG ILYGRGAADM KGSVAAFVIA AERFLAAYPQ 

       130        140        150        160        170        180 
HPGTLAILLT SDEEGQAIDG VRKVAETLRQ RGQGIDWCLT GEPSSSKRLG DLLRVGRRGS 

       190        200        210        220        230        240 
LSATLHVKGV QGHVAYPHQA RNPIHLALPA FAALTARHWD DGYESFPSTS LQISNIHAGT 

       250        260        270        280        290        300 
GANNVIPGAL EVAFNLRYNP HWIAPRLESE IVALLDQHGL DYTLHWHRSG EPFYTPEGKL 

       310        320        330        340        350        360 
RRIAREVLER FSGAPPEEST GGGTSDARFI APLGAQCIEV GPVNASIHQV DEHVCLSDLE 

       370 
ALPDLYQLLI ERLLAEH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE009442 Genomic DNA. Translation: AAO27988.1.
RefSeqNP_778339.1. NC_004556.1.

3D structure databases

ProteinModelPortalQ87F49.
SMRQ87F49. Positions 2-374.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING183190.PD0088.

Protein family/group databases

MEROPSM20.010.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO27988; AAO27988; PD_0088.
GeneID1144300.
KEGGxft:PD0088.
PATRIC24147572. VBIXylFas71109_0122.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0624.
KOK01439.
OMALNSTIHK.
OrthoDBEOG60651W.

Enzyme and pathway databases

BioCycXFAS183190:GIX4-88-MONOMER.
UniPathwayUPA00034; UER00021.

Family and domain databases

Gene3D3.30.70.360. 1 hit.
HAMAPMF_01690. DapE.
InterProIPR001261. ArgE/DapE_CS.
IPR005941. DapE_proteobac.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
SUPFAMSSF55031. SSF55031. 1 hit.
TIGRFAMsTIGR01246. dapE_proteo. 1 hit.
PROSITEPS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPE_XYLFT
AccessionPrimary (citable) accession number: Q87F49
Entry history
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

PATHWAY comments

Index of metabolic and biosynthesis pathways