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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Xylella fastidiosa (strain Temecula1 / ATCC 700964)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (pncB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Transferase
Biological processPyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:PD_0393
OrganismiXylella fastidiosa (strain Temecula1 / ATCC 700964)
Taxonomic identifieri183190 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella
Proteomesi
  • UP000002516 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002058541 – 394Nicotinate phosphoribosyltransferaseAdd BLAST394

Structurei

3D structure databases

ProteinModelPortaliQ87EC4
SMRiQ87EC4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

KOiK00763
OMAiKLTMQCA

Family and domain databases

CDDicd01401 PncB_like, 1 hit
HAMAPiMF_00570 NAPRTase, 1 hit
InterProiView protein in InterPro
IPR006406 Nic_PRibTrfase
IPR007229 Nic_PRibTrfase-Fam
IPR036068 Nicotinate_pribotase_like_C
PANTHERiPTHR11098 PTHR11098, 1 hit
PfamiView protein in Pfam
PF04095 NAPRTase, 1 hit
PIRSFiPIRSF000484 NAPRT, 1 hit
SUPFAMiSSF51690 SSF51690, 1 hit
TIGRFAMsiTIGR01514 NAPRTase, 1 hit

Sequencei

Sequence statusi: Complete.

Q87EC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFIIKSLLD TDLYKFTMMQ AVLHQYPGAQ VEYRFKCRTP GVDLARFINE
60 70 80 90 100
ISHEIDGLCG LCFSKEELDY LRGLRFMKPD FVDFLGLFHL DRKYLQLRAS
110 120 130 140 150
SQVPGEIELD IRGPWLHTIL FEVPLLAIIN EVWFRNTSVL NLDVGRDRLD
160 170 180 190 200
AKVRLLKDES GYEECSIADY GTRRRYSRQW HAELLPLLAQ GLGSNFVGTS
210 220 230 240 250
NVYFAKQYGY TPLGTMAHEY LQAFQALGPR LRDSQVAGLE AWAREYRGDL
260 270 280 290 300
GIALSDVVGL DAFLGDFDLY FCKLFDGMRH DSGDPFKWGE RIIMHLESHR
310 320 330 340 350
IDPRTKVLVF SDGLDMNKVM RLYQHFRGRC RLAFGVGTSL TNDLGPTPLQ
360 370 380 390
IVIKMVRCNG QPVAKLSDSP GKSMCDDPGY LHYLRQVFGV SADV
Length:394
Mass (Da):45,007
Last modified:June 16, 2003 - v1
Checksum:iC7D5F4DE7EC8595B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009442 Genomic DNA Translation: AAO28273.1
RefSeqiWP_011097631.1, NC_004556.1

Genome annotation databases

EnsemblBacteriaiAAO28273; AAO28273; PD_0393
KEGGixft:PD_0393

Similar proteinsi

Entry informationi

Entry nameiPNCB_XYLFT
AccessioniPrimary (citable) accession number: Q87EC4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 16, 2003
Last modified: April 25, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health