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Q87DR8 (TRPA_XYLFT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan synthase alpha chain

EC=4.2.1.20
Gene names
Name:trpA
Ordered Locus Names:PD_0613
OrganismXylella fastidiosa (strain Temecula1 / ATCC 700964) [Complete proteome] [HAMAP]
Taxonomic identifier183190 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella

Protein attributes

Sequence length268 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate By similarity. HAMAP-Rule MF_00131

Catalytic activity

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O. HAMAP-Rule MF_00131

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5. HAMAP-Rule MF_00131

Subunit structure

Tetramer of two alpha and two beta chains By similarity.

Sequence similarities

Belongs to the TrpA family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
Tryptophan biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functiontryptophan synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 268268Tryptophan synthase alpha chain HAMAP-Rule MF_00131
PRO_0000098879

Sites

Active site491Proton acceptor By similarity
Active site601Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q87DR8 [UniParc].

Last modified June 16, 2003. Version 1.
Checksum: B9603DBC89020E4C

FASTA26828,079
        10         20         30         40         50         60 
MHRIDETFRR LRAQSRKALI PFITAGDPSL EAAVPVMHAL VRAGADVIEL GVPFSDPMAD 

        70         80         90        100        110        120 
GPVIQHSSER ALQRGVGLAY VLQTVDVFRQ SDAVTPVVLM GYLNPLEIYG IARFTQQALA 

       130        140        150        160        170        180 
SGVDGVLLVD LPPEEADEIR AIFSAAGLAL IVLASPTTSA SRLATLSGVA QGYLYYVSFA 

       190        200        210        220        230        240 
GVTGADRLDA QSAGDRLRGL RAQTQVPVVV GFGIRDAASA VVMAVDADGV VVGSALVTAL 

       250        260 
SDAPDVDTAC RRADAFLAPL RQALDAVK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE009442 Genomic DNA. Translation: AAO28485.1.
RefSeqNP_778836.1. NC_004556.1.

3D structure databases

ProteinModelPortalQ87DR8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING183190.PD0613.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO28485; AAO28485; PD_0613.
GeneID1144816.
KEGGxft:PD0613.
PATRIC24148974. VBIXylFas71109_0802.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0159.
KOK01695.
OMADYPPEEC.
OrthoDBEOG6RVG0K.
ProtClustDBPRK13111.

Enzyme and pathway databases

BioCycXFAS183190:GIX4-613-MONOMER.
UniPathwayUPA00035; UER00044.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00131. Trp_synth_alpha.
InterProIPR013785. Aldolase_TIM.
IPR011060. RibuloseP-bd_barrel.
IPR018204. Trp_synthase_alpha_AS.
IPR002028. Trp_synthase_suA.
[Graphical view]
PfamPF00290. Trp_syntA. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR00262. trpA. 1 hit.
PROSITEPS00167. TRP_SYNTHASE_ALPHA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRPA_XYLFT
AccessionPrimary (citable) accession number: Q87DR8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 16, 2003
Last modified: February 19, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways