SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q87DR8

- TRPA_XYLFT

UniProt

Q87DR8 - TRPA_XYLFT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Tryptophan synthase alpha chain
Gene
trpA, PD_0613
Organism
Xylella fastidiosa (strain Temecula1 / ATCC 700964)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate By similarity.UniRule annotation

Catalytic activityi

L-serine + 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + D-glyceraldehyde 3-phosphate + H2O.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei49 – 491Proton acceptor By similarity
Active sitei60 – 601Proton acceptor By similarity

GO - Molecular functioni

  1. tryptophan synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

    Enzyme and pathway databases

    BioCyciXFAS183190:GIX4-613-MONOMER.
    UniPathwayiUPA00035; UER00044.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan synthase alpha chain (EC:4.2.1.20)
    Gene namesi
    Name:trpA
    Ordered Locus Names:PD_0613
    OrganismiXylella fastidiosa (strain Temecula1 / ATCC 700964)
    Taxonomic identifieri183190 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella
    ProteomesiUP000002516: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 268268Tryptophan synthase alpha chainUniRule annotation
    PRO_0000098879Add
    BLAST

    Interactioni

    Subunit structurei

    Tetramer of two alpha and two beta chains By similarity.

    Protein-protein interaction databases

    STRINGi183190.PD0613.

    Structurei

    3D structure databases

    ProteinModelPortaliQ87DR8.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TrpA family.

    Phylogenomic databases

    eggNOGiCOG0159.
    KOiK01695.
    OMAiNSEGYTY.
    OrthoDBiEOG6RVG0K.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00131. Trp_synth_alpha.
    InterProiIPR013785. Aldolase_TIM.
    IPR011060. RibuloseP-bd_barrel.
    IPR018204. Trp_synthase_alpha_AS.
    IPR002028. Trp_synthase_suA.
    [Graphical view]
    PfamiPF00290. Trp_syntA. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR00262. trpA. 1 hit.
    PROSITEiPS00167. TRP_SYNTHASE_ALPHA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q87DR8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHRIDETFRR LRAQSRKALI PFITAGDPSL EAAVPVMHAL VRAGADVIEL    50
    GVPFSDPMAD GPVIQHSSER ALQRGVGLAY VLQTVDVFRQ SDAVTPVVLM 100
    GYLNPLEIYG IARFTQQALA SGVDGVLLVD LPPEEADEIR AIFSAAGLAL 150
    IVLASPTTSA SRLATLSGVA QGYLYYVSFA GVTGADRLDA QSAGDRLRGL 200
    RAQTQVPVVV GFGIRDAASA VVMAVDADGV VVGSALVTAL SDAPDVDTAC 250
    RRADAFLAPL RQALDAVK 268
    Length:268
    Mass (Da):28,079
    Last modified:June 16, 2003 - v1
    Checksum:iB9603DBC89020E4C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009442 Genomic DNA. Translation: AAO28485.1.
    RefSeqiNP_778836.1. NC_004556.1.

    Genome annotation databases

    EnsemblBacteriaiAAO28485; AAO28485; PD_0613.
    GeneIDi1144816.
    KEGGixft:PD0613.
    PATRICi24148974. VBIXylFas71109_0802.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009442 Genomic DNA. Translation: AAO28485.1 .
    RefSeqi NP_778836.1. NC_004556.1.

    3D structure databases

    ProteinModelPortali Q87DR8.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 183190.PD0613.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO28485 ; AAO28485 ; PD_0613 .
    GeneIDi 1144816.
    KEGGi xft:PD0613.
    PATRICi 24148974. VBIXylFas71109_0802.

    Phylogenomic databases

    eggNOGi COG0159.
    KOi K01695.
    OMAi NSEGYTY.
    OrthoDBi EOG6RVG0K.

    Enzyme and pathway databases

    UniPathwayi UPA00035 ; UER00044 .
    BioCyci XFAS183190:GIX4-613-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00131. Trp_synth_alpha.
    InterProi IPR013785. Aldolase_TIM.
    IPR011060. RibuloseP-bd_barrel.
    IPR018204. Trp_synthase_alpha_AS.
    IPR002028. Trp_synthase_suA.
    [Graphical view ]
    Pfami PF00290. Trp_syntA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR00262. trpA. 1 hit.
    PROSITEi PS00167. TRP_SYNTHASE_ALPHA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative analyses of the complete genome sequences of Pierce's disease and citrus variegated chlorosis strains of Xylella fastidiosa."
      Van Sluys M.A., de Oliveira M.C., Monteiro-Vitorello C.B., Miyaki C.Y., Furlan L.R., Camargo L.E.A., da Silva A.C.R., Moon D.H., Takita M.A., Lemos E.G.M., Machado M.A., Ferro M.I.T., da Silva F.R., Goldman M.H.S., Goldman G.H., Lemos M.V.F., El-Dorry H., Tsai S.M.
      , Carrer H., Carraro D.M., de Oliveira R.C., Nunes L.R., Siqueira W.J., Coutinho L.L., Kimura E.T., Ferro E.S., Harakava R., Kuramae E.E., Marino C.L., Giglioti E., Abreu I.L., Alves L.M.C., do Amaral A.M., Baia G.S., Blanco S.R., Brito M.S., Cannavan F.S., Celestino A.V., da Cunha A.F., Fenille R.C., Ferro J.A., Formighieri E.F., Kishi L.T., Leoni S.G., Oliveira A.R., Rosa V.E. Jr., Sassaki F.T., Sena J.A.D., de Souza A.A., Truffi D., Tsukumo F., Yanai G.M., Zaros L.G., Civerolo E.L., Simpson A.J.G., Almeida N.F. Jr., Setubal J.C., Kitajima J.P.
      J. Bacteriol. 185:1018-1026(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Temecula1 / ATCC 700964.

    Entry informationi

    Entry nameiTRPA_XYLFT
    AccessioniPrimary (citable) accession number: Q87DR8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2003
    Last sequence update: June 16, 2003
    Last modified: May 14, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi