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Q87DR1 (GCSP_XYLFT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:PD_0620
OrganismXylella fastidiosa (strain Temecula1 / ATCC 700964) [Complete proteome] [HAMAP]
Taxonomic identifier183190 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella

Protein attributes

Sequence length993 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 993993Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000166951

Amino acid modifications

Modified residue7151N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q87DR1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: BCC04E829C442F43

FASTA993107,647
        10         20         30         40         50         60 
MFSASHFCSG SLMMSHPLSS LRDLEYHGAF VERHIGPNDV EIAQMLRVVG YDSLESLTDA 

        70         80         90        100        110        120 
IVPEKIRSTV ALDLPKGITE EEALAKIRVI ANKNRVFRSF IGQGYYGTHT PKVILRNILE 

       130        140        150        160        170        180 
NPAWYTAYTP YQAEISQGRM EALINFQTMC ADLTGMEIAN ASLLDEATAA AEAMSLAKRS 

       190        200        210        220        230        240 
AKSRSDLFFV HDAVHPQTLE LLRTRAEPLG IVLRVGTPEE ALQVDVFGIL LQYPDTFGRI 

       250        260        270        280        290        300 
GDHRVLADAV HARGGLVAVA SDLLALTLIT PPGEWGADIV VGNSQRFGVP FGFGGPHAGF 

       310        320        330        340        350        360 
MACRDIYKRS IPGRLIGVSV DAAGHPAYRL ALQTREQHIR REKATSNICT AQVLLAVMAS 

       370        380        390        400        410        420 
MYAVYHGPQG LLRIAWRTHR MAAILAAALR GAGLTVGEYF FDTLHIVGID ALAIHCAAAA 

       430        440        450        460        470        480 
AGMNLRMIDN AQIGISLDET VTRSDVVALG QVFGVQVDVE ALDAITADAL PAGLLRSSAF 

       490        500        510        520        530        540 
LTHPVFNTHH SEHELLRYLR MLADKDLAMD RTMIPLGSCT MKLNATAEMI PVTWQEFACI 

       550        560        570        580        590        600 
HPLAPVVQWS GYRQLIDELE AMLVECTGYD AISLQPNSGA QGEYAGLLAI RAYHRSRGEE 

       610        620        630        640        650        660 
RRNVCLIPES AHGTNPASAQ LCGMQVVIIK CDRSGNVDVD DLRMKAEKYS DTLAALMVTY 

       670        680        690        700        710        720 
PSTHGVFEEA ITEICEIVHA HGGQVYTDGA NMNALVGVAK PGRWGSDVSH LNLHKTFCIP 

       730        740        750        760        770        780 
HGGGGPGVGP CAVKAHLAPF LPKTLPLPGD AAGLPVQGTQ EAKVGMVSAA NFGSASILPV 

       790        800        810        820        830        840 
SWMYITMMGA AGLRKATQVA LLNANYIAKR LAPHYKTLYT GRHGLVAHEC ILDVRSLEKV 

       850        860        870        880        890        900 
SGVSAEDIAK RLIDFGFHAP TLSFPVAGTL MVEPTESESQ QELDRFVDAM IQIRGEIAAI 

       910        920        930        940        950        960 
EKGHLDPEDN PLKQAPHTAV QVMASQWGHA YSRELAAFPL GVLHHAKYWP PVARVDNVYG 

       970        980        990 
DKHVMCACIP VEAYKEKGDS EIQDLIEEDA SRC 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE009442 Genomic DNA. Translation: AAO28492.1.
RefSeqNP_778843.1. NC_004556.1.

3D structure databases

ProteinModelPortalQ87DR1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING183190.PD0620.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO28492; AAO28492; PD_0620.
GeneID1144823.
KEGGxft:PD0620.
PATRIC24148996. VBIXylFas71109_0813.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
KOK00281.
OMAIRVQVII.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycXFAS183190:GIX4-620-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_XYLFT
AccessionPrimary (citable) accession number: Q87DR1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2003
Last modified: February 19, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families