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Q87DR1

- GCSP_XYLFT

UniProt

Q87DR1 - GCSP_XYLFT

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Xylella fastidiosa (strain Temecula1 / ATCC 700964)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciXFAS183190:GIX4-620-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:PD_0620
    OrganismiXylella fastidiosa (strain Temecula1 / ATCC 700964)
    Taxonomic identifieri183190 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella
    ProteomesiUP000002516: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 993993Glycine dehydrogenase (decarboxylating)PRO_0000166951Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei715 – 7151N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi183190.PD0620.

    Structurei

    3D structure databases

    ProteinModelPortaliQ87DR1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    KOiK00281.
    OMAiAELMPVS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q87DR1-1 [UniParc]FASTAAdd to Basket

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    MFSASHFCSG SLMMSHPLSS LRDLEYHGAF VERHIGPNDV EIAQMLRVVG    50
    YDSLESLTDA IVPEKIRSTV ALDLPKGITE EEALAKIRVI ANKNRVFRSF 100
    IGQGYYGTHT PKVILRNILE NPAWYTAYTP YQAEISQGRM EALINFQTMC 150
    ADLTGMEIAN ASLLDEATAA AEAMSLAKRS AKSRSDLFFV HDAVHPQTLE 200
    LLRTRAEPLG IVLRVGTPEE ALQVDVFGIL LQYPDTFGRI GDHRVLADAV 250
    HARGGLVAVA SDLLALTLIT PPGEWGADIV VGNSQRFGVP FGFGGPHAGF 300
    MACRDIYKRS IPGRLIGVSV DAAGHPAYRL ALQTREQHIR REKATSNICT 350
    AQVLLAVMAS MYAVYHGPQG LLRIAWRTHR MAAILAAALR GAGLTVGEYF 400
    FDTLHIVGID ALAIHCAAAA AGMNLRMIDN AQIGISLDET VTRSDVVALG 450
    QVFGVQVDVE ALDAITADAL PAGLLRSSAF LTHPVFNTHH SEHELLRYLR 500
    MLADKDLAMD RTMIPLGSCT MKLNATAEMI PVTWQEFACI HPLAPVVQWS 550
    GYRQLIDELE AMLVECTGYD AISLQPNSGA QGEYAGLLAI RAYHRSRGEE 600
    RRNVCLIPES AHGTNPASAQ LCGMQVVIIK CDRSGNVDVD DLRMKAEKYS 650
    DTLAALMVTY PSTHGVFEEA ITEICEIVHA HGGQVYTDGA NMNALVGVAK 700
    PGRWGSDVSH LNLHKTFCIP HGGGGPGVGP CAVKAHLAPF LPKTLPLPGD 750
    AAGLPVQGTQ EAKVGMVSAA NFGSASILPV SWMYITMMGA AGLRKATQVA 800
    LLNANYIAKR LAPHYKTLYT GRHGLVAHEC ILDVRSLEKV SGVSAEDIAK 850
    RLIDFGFHAP TLSFPVAGTL MVEPTESESQ QELDRFVDAM IQIRGEIAAI 900
    EKGHLDPEDN PLKQAPHTAV QVMASQWGHA YSRELAAFPL GVLHHAKYWP 950
    PVARVDNVYG DKHVMCACIP VEAYKEKGDS EIQDLIEEDA SRC 993
    Length:993
    Mass (Da):107,647
    Last modified:June 1, 2003 - v1
    Checksum:iBCC04E829C442F43
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009442 Genomic DNA. Translation: AAO28492.1.
    RefSeqiNP_778843.1. NC_004556.1.
    WP_011097725.1. NC_004556.1.

    Genome annotation databases

    EnsemblBacteriaiAAO28492; AAO28492; PD_0620.
    GeneIDi1144823.
    KEGGixft:PD0620.
    PATRICi24148996. VBIXylFas71109_0813.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009442 Genomic DNA. Translation: AAO28492.1 .
    RefSeqi NP_778843.1. NC_004556.1.
    WP_011097725.1. NC_004556.1.

    3D structure databases

    ProteinModelPortali Q87DR1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 183190.PD0620.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO28492 ; AAO28492 ; PD_0620 .
    GeneIDi 1144823.
    KEGGi xft:PD0620.
    PATRICi 24148996. VBIXylFas71109_0813.

    Phylogenomic databases

    eggNOGi COG1003.
    KOi K00281.
    OMAi AELMPVS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci XFAS183190:GIX4-620-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative analyses of the complete genome sequences of Pierce's disease and citrus variegated chlorosis strains of Xylella fastidiosa."
      Van Sluys M.A., de Oliveira M.C., Monteiro-Vitorello C.B., Miyaki C.Y., Furlan L.R., Camargo L.E.A., da Silva A.C.R., Moon D.H., Takita M.A., Lemos E.G.M., Machado M.A., Ferro M.I.T., da Silva F.R., Goldman M.H.S., Goldman G.H., Lemos M.V.F., El-Dorry H., Tsai S.M.
      , Carrer H., Carraro D.M., de Oliveira R.C., Nunes L.R., Siqueira W.J., Coutinho L.L., Kimura E.T., Ferro E.S., Harakava R., Kuramae E.E., Marino C.L., Giglioti E., Abreu I.L., Alves L.M.C., do Amaral A.M., Baia G.S., Blanco S.R., Brito M.S., Cannavan F.S., Celestino A.V., da Cunha A.F., Fenille R.C., Ferro J.A., Formighieri E.F., Kishi L.T., Leoni S.G., Oliveira A.R., Rosa V.E. Jr., Sassaki F.T., Sena J.A.D., de Souza A.A., Truffi D., Tsukumo F., Yanai G.M., Zaros L.G., Civerolo E.L., Simpson A.J.G., Almeida N.F. Jr., Setubal J.C., Kitajima J.P.
      J. Bacteriol. 185:1018-1026(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Temecula1 / ATCC 700964.

    Entry informationi

    Entry nameiGCSP_XYLFT
    AccessioniPrimary (citable) accession number: Q87DR1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3