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Q87DR1

- GCSP_XYLFT

UniProt

Q87DR1 - GCSP_XYLFT

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, PD_0620
Organism
Xylella fastidiosa (strain Temecula1 / ATCC 700964)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciXFAS183190:GIX4-620-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:PD_0620
OrganismiXylella fastidiosa (strain Temecula1 / ATCC 700964)
Taxonomic identifieri183190 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella
ProteomesiUP000002516: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 993993Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_0000166951Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei715 – 7151N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi183190.PD0620.

Structurei

3D structure databases

ProteinModelPortaliQ87DR1.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
KOiK00281.
OMAiAELMPVS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q87DR1-1 [UniParc]FASTAAdd to Basket

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MFSASHFCSG SLMMSHPLSS LRDLEYHGAF VERHIGPNDV EIAQMLRVVG    50
YDSLESLTDA IVPEKIRSTV ALDLPKGITE EEALAKIRVI ANKNRVFRSF 100
IGQGYYGTHT PKVILRNILE NPAWYTAYTP YQAEISQGRM EALINFQTMC 150
ADLTGMEIAN ASLLDEATAA AEAMSLAKRS AKSRSDLFFV HDAVHPQTLE 200
LLRTRAEPLG IVLRVGTPEE ALQVDVFGIL LQYPDTFGRI GDHRVLADAV 250
HARGGLVAVA SDLLALTLIT PPGEWGADIV VGNSQRFGVP FGFGGPHAGF 300
MACRDIYKRS IPGRLIGVSV DAAGHPAYRL ALQTREQHIR REKATSNICT 350
AQVLLAVMAS MYAVYHGPQG LLRIAWRTHR MAAILAAALR GAGLTVGEYF 400
FDTLHIVGID ALAIHCAAAA AGMNLRMIDN AQIGISLDET VTRSDVVALG 450
QVFGVQVDVE ALDAITADAL PAGLLRSSAF LTHPVFNTHH SEHELLRYLR 500
MLADKDLAMD RTMIPLGSCT MKLNATAEMI PVTWQEFACI HPLAPVVQWS 550
GYRQLIDELE AMLVECTGYD AISLQPNSGA QGEYAGLLAI RAYHRSRGEE 600
RRNVCLIPES AHGTNPASAQ LCGMQVVIIK CDRSGNVDVD DLRMKAEKYS 650
DTLAALMVTY PSTHGVFEEA ITEICEIVHA HGGQVYTDGA NMNALVGVAK 700
PGRWGSDVSH LNLHKTFCIP HGGGGPGVGP CAVKAHLAPF LPKTLPLPGD 750
AAGLPVQGTQ EAKVGMVSAA NFGSASILPV SWMYITMMGA AGLRKATQVA 800
LLNANYIAKR LAPHYKTLYT GRHGLVAHEC ILDVRSLEKV SGVSAEDIAK 850
RLIDFGFHAP TLSFPVAGTL MVEPTESESQ QELDRFVDAM IQIRGEIAAI 900
EKGHLDPEDN PLKQAPHTAV QVMASQWGHA YSRELAAFPL GVLHHAKYWP 950
PVARVDNVYG DKHVMCACIP VEAYKEKGDS EIQDLIEEDA SRC 993
Length:993
Mass (Da):107,647
Last modified:June 1, 2003 - v1
Checksum:iBCC04E829C442F43
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009442 Genomic DNA. Translation: AAO28492.1.
RefSeqiNP_778843.1. NC_004556.1.
WP_011097725.1. NC_004556.1.

Genome annotation databases

EnsemblBacteriaiAAO28492; AAO28492; PD_0620.
GeneIDi1144823.
KEGGixft:PD0620.
PATRICi24148996. VBIXylFas71109_0813.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009442 Genomic DNA. Translation: AAO28492.1 .
RefSeqi NP_778843.1. NC_004556.1.
WP_011097725.1. NC_004556.1.

3D structure databases

ProteinModelPortali Q87DR1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 183190.PD0620.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO28492 ; AAO28492 ; PD_0620 .
GeneIDi 1144823.
KEGGi xft:PD0620.
PATRICi 24148996. VBIXylFas71109_0813.

Phylogenomic databases

eggNOGi COG1003.
KOi K00281.
OMAi AELMPVS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci XFAS183190:GIX4-620-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative analyses of the complete genome sequences of Pierce's disease and citrus variegated chlorosis strains of Xylella fastidiosa."
    Van Sluys M.A., de Oliveira M.C., Monteiro-Vitorello C.B., Miyaki C.Y., Furlan L.R., Camargo L.E.A., da Silva A.C.R., Moon D.H., Takita M.A., Lemos E.G.M., Machado M.A., Ferro M.I.T., da Silva F.R., Goldman M.H.S., Goldman G.H., Lemos M.V.F., El-Dorry H., Tsai S.M.
    , Carrer H., Carraro D.M., de Oliveira R.C., Nunes L.R., Siqueira W.J., Coutinho L.L., Kimura E.T., Ferro E.S., Harakava R., Kuramae E.E., Marino C.L., Giglioti E., Abreu I.L., Alves L.M.C., do Amaral A.M., Baia G.S., Blanco S.R., Brito M.S., Cannavan F.S., Celestino A.V., da Cunha A.F., Fenille R.C., Ferro J.A., Formighieri E.F., Kishi L.T., Leoni S.G., Oliveira A.R., Rosa V.E. Jr., Sassaki F.T., Sena J.A.D., de Souza A.A., Truffi D., Tsukumo F., Yanai G.M., Zaros L.G., Civerolo E.L., Simpson A.J.G., Almeida N.F. Jr., Setubal J.C., Kitajima J.P.
    J. Bacteriol. 185:1018-1026(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Temecula1 / ATCC 700964.

Entry informationi

Entry nameiGCSP_XYLFT
AccessioniPrimary (citable) accession number: Q87DR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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