Reviewed, UniProtKB/Swiss-Prot Q87DF8 (PIP_XYLFT)

Names and origin

Protein names

Recommended name:
    Proline iminopeptidase
      Short name=PIP
    EC=3.4.11.5
Alternative name(s):
    Prolyl aminopeptidase
      Short name=PAP

Gene names

Name:	pip
Ordered Locus Names:	PD_0727

Organism

Xylella fastidiosa (strain Temecula1 / ATCC 700964) [Complete proteome] [HAMAP]

Taxonomic identifier

183190 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xylella

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Specifically catalyzes the removal of N-terminal proline residues from peptides By similarity.
Catalytic activity	Release of N-terminal proline from a peptide.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the peptidase S33 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Aminopeptidase Hydrolase Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 313	313	Proline iminopeptidase		PRO_0000080849
Sites
	Active site	110	1	Nucleophile By similarity
	Active site	266	1	By similarity
	Active site	294	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q87DF8-1 [UniParc]. Last modified June 16, 2003. Version 1. Checksum: 0E2A201E7FA9F0FD	FASTA	313	35,519
	10 20 30 40 50 60 MRTLYPEVTP FDHGMLCVDD SHRLYYEQCG NPHGKPVVIL HGGPGGGCND KMRRFHDPDK 70 80 90 100 110 120 YRIVLFDQRG AGRSMPHANL TNNTTWDLVA DIEKLRVALG ITRWQVFGGS WGSTLALAYA 130 140 150 160 170 180 QTHPEQTTEL VLRGIFMLRR WELEWFYQEG ASRLFPDAWD RYIAAIPPVE RHDLISAFHR 190 200 210 220 230 240 RLTSDDEATR LAAAQAWSLW EGATSCLYMD QDFIASHENP HFALAFARIE NHYFVNGGFF 250 260 270 280 290 300 EVEDQLLRDA QRIANIPGVI VHGRYDVVCP LQNAWDLHKA WPKASLKITP GAGHSAFEPQ 310 NIDALVCATD SFV

References

[1]

"Comparative analyses of the complete genome sequences of Pierce's disease and citrus variegated chlorosis strains of Xylella fastidiosa." Van Sluys M.A., de Oliveira M.C., Monteiro-Vitorello C.B., Miyaki C.Y., Furlan L.R., Camargo L.E.A., da Silva A.C.R., Moon D.H., Takita M.A., Lemos E.G.M., Machado M.A., Ferro M.I.T., da Silva F.R., Goldman M.H.S., Goldman G.H., Lemos M.V.F., El-Dorry H., Tsai S.M. , Carrer H., Carraro D.M., de Oliveira R.C., Nunes L.R., Siqueira W.J., Coutinho L.L., Kimura E.T., Ferro E.S., Harakava R., Kuramae E.E., Marino C.L., Giglioti E., Abreu I.L., Alves L.M.C., do Amaral A.M., Baia G.S., Blanco S.R., Brito M.S., Cannavan F.S., Celestino A.V., da Cunha A.F., Fenille R.C., Ferro J.A., Formighieri E.F., Kishi L.T., Leoni S.G., Oliveira A.R., Rosa V.E. Jr., Sassaki F.T., Sena J.A.D., de Souza A.A., Truffi D., Tsukumo F., Yanai G.M., Zaros L.G., Civerolo E.L., Simpson A.J.G., Almeida N.F. Jr., Setubal J.C., Kitajima J.P. J. Bacteriol. 185:1018-1026(2003) [PubMed: 12533478] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE009442 Genomic DNA. Translation: AAO28596.1.
RefSeq	NP_778947.1.
3D structure databases
HSSP	HSSP built from PDB template 1AZW based on UniProtKB P52279.
SMR	Q87DF8. Positions 1-312.
ModBase	Search...
Protein-protein interaction databases
STRING	Q87DF8.
Protein family/group databases
MEROPS	S33.001.
Genome annotation databases
GeneID	1144930.
GenomeReviews	Gene locus PD_0727 in contig AE009442_GR.
KEGG	xft:PD0727.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q87DF8.
OMA	RLENHYF.
Enzyme and pathway databases
BioCyc	XFAS183190:PD_0727-MON.
Family and domain databases
InterPro	IPR000073. AB_hydrolase_1. IPR005944. Pept_S33. IPR002410. Peptidase_S33. [Graphical view]
Pfam	PF00561. Abhydrolase_1. 1 hit. [Graphical view]
PIRSF	PIRSF006431. Pept_S33. 1 hit.
PRINTS	PR00793. PROAMNOPTASE.
TIGRFAMs	TIGR01249. pro_imino_pep_1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PIP_XYLFT

Accession

Primary (citable) accession number: Q87DF8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 16, 2003
Last sequence update:	June 16, 2003
Last modified:	November 3, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)