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Q87DA5 (GCH4_XYLFT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:PD_0781
OrganismXylella fastidiosa (strain Temecula1 / ATCC 700964) [Complete proteome] [HAMAP]
Taxonomic identifier183190 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella

Protein attributes

Sequence length298 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Sequence caution

The sequence AAO28649.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 298298GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_0000147737

Sites

Site1551May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
Q87DA5 [UniParc].

Last modified May 5, 2009. Version 2.
Checksum: 147C68D489CA9086

FASTA29832,516
        10         20         30         40         50         60 
MSTSIPDVAV HDSPAIAAPL RWVGMDGIVV PVQLTTADGG QHVIGRARAQ IDLPAMGVKG 

        70         80         90        100        110        120 
IHMSRLYRLL DTYAVEPLTP VGICGLLSAM VNSHADCAST AARVDWYFDW LRRVPALVSN 

       130        140        150        160        170        180 
DLSGWRGYPV WLRAEYSAGH VQFWLCVEVA YSSTCPCSAA LARQMLADAF LQEHVEVSAL 

       190        200        210        220        230        240 
SPETVADWLR SNGSYATPHS QRSLARIEVA LTEQAVELGL PALVDCAERI LSTPVQAAVR 

       250        260        270        280        290 
RVDEQAFARL NGANLMYVED ATRRLQHGLA IHYSAFRVHV RHLESLHPND AVASTADE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE009442 Genomic DNA. Translation: AAO28649.1. Different initiation.
RefSeqNP_779000.1. NC_004556.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING183190.PD0781.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO28649; AAO28649; PD_0781.
GeneID1143503.
KEGGxft:PD0781.
PATRIC24149387. VBIXylFas71109_1007.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
KOK09007.
OMAAGRTTIQ.
OrthoDBEOG6X6RBH.

Enzyme and pathway databases

BioCycXFAS183190:GIX4-781-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_XYLFT
AccessionPrimary (citable) accession number: Q87DA5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: May 5, 2009
Last modified: May 14, 2014
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways