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Protein

NAD kinase

Gene

nadK

Organism
Xylella fastidiosa (strain Temecula1 / ATCC 700964)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei49Proton acceptorUniRule annotation1
Binding sitei54NADUniRule annotation1
Binding sitei148NADUniRule annotation1
Binding sitei156NAD; via carbonyl oxygenUniRule annotation1
Binding sitei183NAD; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi49 – 50NADUniRule annotation2
Nucleotide bindingi118 – 119NADUniRule annotation2
Nucleotide bindingi159 – 164NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:PD_0786
OrganismiXylella fastidiosa (strain Temecula1 / ATCC 700964)
Taxonomic identifieri183190 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella
Proteomesi
  • UP000002516 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001206941 – 259NAD kinaseAdd BLAST259

Structurei

3D structure databases

ProteinModelPortaliQ87DA0.
SMRiQ87DA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

KOiK00858.
OMAiNGIERMS.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase. 1 hit.
InterProiView protein in InterPro
IPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiView protein in Pfam
PF01513. NAD_kinase. 1 hit.
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q87DA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMMMTAAPR IAFLASTAEP AQRARQELMA RYGDCSIEEA DVLCALGGDG
60 70 80 90 100
FMLRTLHRHG ASGKPVYGMK LGSVGFLMNQ YHDDLLERLQ RAEPAKLRPL
110 120 130 140 150
QMMAQTESGV SVESLAYNEV SLLRQTHQAA YISIDLNGQT RIDELTGDGV
160 170 180 190 200
IVATPAGSTA YNYSAHGPIL PLGSHTLALT PIAPYRPRRW RGAILKADTE
210 220 230 240 250
IRLRVLDPYK RPVSVTADSH EIRDVVEVTI RESTEQRVTL LFDPEHNLEE

RIFSEQFAF
Length:259
Mass (Da):28,840
Last modified:June 16, 2003 - v1
Checksum:i1890D4E336C8A2D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009442 Genomic DNA. Translation: AAO28654.1.

Genome annotation databases

EnsemblBacteriaiAAO28654; AAO28654; PD_0786.
KEGGixft:PD_0786.

Similar proteinsi

Entry informationi

Entry nameiNADK_XYLFT
AccessioniPrimary (citable) accession number: Q87DA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 16, 2003
Last modified: September 27, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families