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Q87D58 (PUR9_XYLFT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:PD_0828
OrganismXylella fastidiosa (strain Temecula1 / ATCC 700964) [Complete proteome] [HAMAP]
Taxonomic identifier183190 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella

Protein attributes

Sequence length527 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 527527Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_0000192152

Sequences

Sequence LengthMass (Da)Tools
Q87D58 [UniParc].

Last modified June 16, 2003. Version 1.
Checksum: 3265D4F5E6BED741

FASTA52756,725
        10         20         30         40         50         60 
MASDFLPVHR ALLSVSDKTG LVELARVLLA YNIELLSTGG TATIIREAGL PVQDVADLTD 

        70         80         90        100        110        120 
FPEMMDGRVK TLHPVVHGGL LGRAGIDDAV MAKHGIAPID LLIVNLYPFE QITAKKDCTL 

       130        140        150        160        170        180 
ADAVDTIDIG GPAMLRSAAK NFARVAVATS PDQYPDLLAE LQAHHGQLSA EKRFALAVAA 

       190        200        210        220        230        240 
FNHVAQYDAA ISNYLSSVSD MHTTLPLRHE FPTQLNNTFV KMTDLRYGEN PHQSGAFYRD 

       250        260        270        280        290        300 
VHPQPGTLAT FKQLQGKRLS YNNLVDADAA WECVRQFEAP ACVIVKHANP CGVAVGTACS 

       310        320        330        340        350        360 
DAYEAAYATD PTSAFGGIIA FNRTLDAVTM QSILDRQFVE VLIAPYYDAD ALAYATKKAN 

       370        380        390        400        410        420 
VRVLRIPSTG AMNRYDFKRI GSGLLVQSAD SLNIHSGALK VVTQLAPTYA QQRDLLFAWH 

       430        440        450        460        470        480 
VAKYVKSNAI VYAKDNRTIG IGAGQMSRVY SARIAGIKAA DAHLAVTGSV MASDAFFPFR 

       490        500        510        520 
DGIDAAAATG IKAVIQPGGS MRDNEVIAAA DEHGIAMVFT GIRHFRH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE009442 Genomic DNA. Translation: AAO28696.1.
RefSeqNP_779047.1. NC_004556.1.

3D structure databases

ProteinModelPortalQ87D58.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING183190.PD0828.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO28696; AAO28696; PD_0828.
GeneID1143550.
KEGGxft:PD0828.
PATRIC24149535. VBIXylFas71109_1081.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0138.
KOK00602.
OMARAFKTDP.
OrthoDBEOG6QCDFF.

Enzyme and pathway databases

BioCycXFAS183190:GIX4-828-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_XYLFT
AccessionPrimary (citable) accession number: Q87D58
Entry history
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 16, 2003
Last modified: May 14, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways