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Q87C65

- SYL_XYLFT

UniProt

Q87C65 - SYL_XYLFT

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Xylella fastidiosa (strain Temecula1 / ATCC 700964)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei640 – 6401ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciXFAS183190:GIX4-1230-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:PD_1230
OrganismiXylella fastidiosa (strain Temecula1 / ATCC 700964)
Taxonomic identifieri183190 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella
ProteomesiUP000002516: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 879879Leucine--tRNA ligasePRO_0000152123Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi183190.PD1230.

Structurei

3D structure databases

ProteinModelPortaliQ87C65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi45 – 5511"HIGH" regionAdd
BLAST
Motifi637 – 6415"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q87C65-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPTEANTYDP QRIESTAQHY WDSTHAFEVN EHSNKPKYYC LSMLPYPSGA
60 70 80 90 100
LHMGHVRNYT IGDVISRYKR MTGHNVLQPM GWDAFGLPAE NAAIKNKVAP
110 120 130 140 150
AQWTYKNIER MRTQLKSLGY AINWSREFAT CQPDYYVHEQ HMFTRLMRKG
160 170 180 190 200
LAYRRNALVN WDPVDQTVLA NEQVIDGRGW RSGAPVEKRE IPQWFLRITD
210 220 230 240 250
YAQELLDGLN TLDDWPEPVK TMQRNWIGRS EGLEIRFEVR DVDNNALEAL
260 270 280 290 300
RVFTTRPDTL FGVTFVSIAP EHPLALHAAK SNPGLAGLLT QMKQGGLSEA
310 320 330 340 350
ELKTQEKRGM DTGLKAIHPI TNEQLPVWVA NFVLMAYGTG AVMAVPGHDQ
360 370 380 390 400
RDQEFANKYG LPIRQVIALK EPKNQDESTW EPDVWRDWYA DKTREFELIN
410 420 430 440 450
SAEFDGLDYQ GAFEVLAERF ERQGRGQRRV NYRLRDWGVS RQRYWGCPIP
460 470 480 490 500
VIYCPTCGAV PVPENQLPVI LPENVAFSGT GSPIKTDPEW RKTTCPECGG
510 520 530 540 550
PAERETDTFD TFMESSWYYA RYTSPNAREM LDKRANYWLP VDQYIGGIEH
560 570 580 590 600
AILHLMYFRF YHKLMRDARL VDSDEPAINL LTQGMVIAET FYRKNPDGSK
610 620 630 640 650
DWINPADVNV ECDERGRITG ATLISDGQPV LIGATEKMSK SKNNGVDPQI
660 670 680 690 700
MVTKYGADTV RLFSMFAAPP EQSLEWNETG VEGMARFLRR LWTQVHHHAS
710 720 730 740 750
HGPATALDIT ALDTAQKAIR CKTHNTIARV EDDYGRRRSF NTAIAAVMEL
760 770 780 790 800
SNTLARFDDT TTQSHAVRQE ALETMVLLLN PITPHTSHAL WQTLGHPETL
810 820 830 840 850
LEDLPFPKVD TTALVRETAI LAVQINGKLR GTIEVATDAP REHIENNALT
860 870
EPNTARFLEG LTVLKIIIVP GKIVNIVAR
Length:879
Mass (Da):99,824
Last modified:June 16, 2003 - v1
Checksum:i4C2EE01B8FDC497E
GO

Sequence cautioni

The sequence AAO29080.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009442 Genomic DNA. Translation: AAO29080.1. Different initiation.
RefSeqiNP_779431.1. NC_004556.1.

Genome annotation databases

EnsemblBacteriaiAAO29080; AAO29080; PD_1230.
GeneIDi1143952.
KEGGixft:PD1230.
PATRICi24150531. VBIXylFas71109_1572.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009442 Genomic DNA. Translation: AAO29080.1 . Different initiation.
RefSeqi NP_779431.1. NC_004556.1.

3D structure databases

ProteinModelPortali Q87C65.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 183190.PD1230.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO29080 ; AAO29080 ; PD_1230 .
GeneIDi 1143952.
KEGGi xft:PD1230.
PATRICi 24150531. VBIXylFas71109_1572.

Phylogenomic databases

eggNOGi COG0495.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci XFAS183190:GIX4-1230-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative analyses of the complete genome sequences of Pierce's disease and citrus variegated chlorosis strains of Xylella fastidiosa."
    Van Sluys M.A., de Oliveira M.C., Monteiro-Vitorello C.B., Miyaki C.Y., Furlan L.R., Camargo L.E.A., da Silva A.C.R., Moon D.H., Takita M.A., Lemos E.G.M., Machado M.A., Ferro M.I.T., da Silva F.R., Goldman M.H.S., Goldman G.H., Lemos M.V.F., El-Dorry H., Tsai S.M.
    , Carrer H., Carraro D.M., de Oliveira R.C., Nunes L.R., Siqueira W.J., Coutinho L.L., Kimura E.T., Ferro E.S., Harakava R., Kuramae E.E., Marino C.L., Giglioti E., Abreu I.L., Alves L.M.C., do Amaral A.M., Baia G.S., Blanco S.R., Brito M.S., Cannavan F.S., Celestino A.V., da Cunha A.F., Fenille R.C., Ferro J.A., Formighieri E.F., Kishi L.T., Leoni S.G., Oliveira A.R., Rosa V.E. Jr., Sassaki F.T., Sena J.A.D., de Souza A.A., Truffi D., Tsukumo F., Yanai G.M., Zaros L.G., Civerolo E.L., Simpson A.J.G., Almeida N.F. Jr., Setubal J.C., Kitajima J.P.
    J. Bacteriol. 185:1018-1026(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Temecula1 / ATCC 700964.

Entry informationi

Entry nameiSYL_XYLFT
AccessioniPrimary (citable) accession number: Q87C65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 16, 2003
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3