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Q87C29

- HISX_XYLFT

UniProt

Q87C29 - HISX_XYLFT

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Protein
Histidinol dehydrogenase
Gene
hisD, PD_1267
Organism
Xylella fastidiosa (strain Temecula1 / ATCC 700964)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei127 – 1271NAD By similarity
Binding sitei189 – 1891NAD By similarity
Binding sitei212 – 2121NAD By similarity
Binding sitei237 – 2371Substrate By similarity
Metal bindingi259 – 2591Zinc By similarity
Binding sitei259 – 2591Substrate By similarity
Metal bindingi262 – 2621Zinc By similarity
Binding sitei262 – 2621Substrate By similarity
Active sitei326 – 3261Proton acceptor By similarity
Active sitei327 – 3271Proton acceptor By similarity
Binding sitei327 – 3271Substrate By similarity
Metal bindingi360 – 3601Zinc By similarity
Binding sitei360 – 3601Substrate By similarity
Binding sitei414 – 4141Substrate By similarity
Metal bindingi419 – 4191Zinc By similarity
Binding sitei419 – 4191Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciXFAS183190:GIX4-1267-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:PD_1267
OrganismiXylella fastidiosa (strain Temecula1 / ATCC 700964)
Taxonomic identifieri183190 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella
ProteomesiUP000002516: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 431431Histidinol dehydrogenaseUniRule annotation
PRO_0000135886Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi183190.PD1267.

Structurei

3D structure databases

ProteinModelPortaliQ87C29.
SMRiQ87C29. Positions 2-429.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q87C29-1 [UniParc]FASTAAdd to Basket

« Hide

MKIIDWNQLD TAAQAKTLTR PAQTIATQTR EAVTALIEQV RRGGDTALRD    50
ITARFDGVDL ATFEVTAAEL AAAATAVAPE LQHAMQTAAA RIEAFHRAGM 100
TNDYRVETAP GVVCERLVRP IARVGLYVPA GSAPLFSTAL MLGVPARLAG 150
CREVVLCTPP SKDGRANPAV LLAARLTGVT RVFTLGGAQA IAAMAYGTAS 200
VPTCDKVFGP GNSFVTEAKQ QLAQAGVVAI DMPAGPSEVL VIADAAANPA 250
FIAADLLSQA EHGPDSQVLL LSDSDALMTA VQNALALQLQ QLSRAEIARQ 300
ALAHSRFIKV ATLETAFDIS NRYAPEHLIL ALRQPRAWLH RVAAAGSVFL 350
GDYTPEALGD YCSGTNHVLP TGGAARAYSG VSVSSFQNMI SVQAASRSGI 400
AEIGGCALTL ARAEGLDAHA NAVALRMGSA P 431
Length:431
Mass (Da):44,839
Last modified:June 6, 2003 - v1
Checksum:i4033BE03F7336FA6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009442 Genomic DNA. Translation: AAO29116.1.
RefSeqiNP_779467.1. NC_004556.1.

Genome annotation databases

EnsemblBacteriaiAAO29116; AAO29116; PD_1267.
GeneIDi1143989.
KEGGixft:PD1267.
PATRICi24150635. VBIXylFas71109_1624.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009442 Genomic DNA. Translation: AAO29116.1 .
RefSeqi NP_779467.1. NC_004556.1.

3D structure databases

ProteinModelPortali Q87C29.
SMRi Q87C29. Positions 2-429.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 183190.PD1267.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO29116 ; AAO29116 ; PD_1267 .
GeneIDi 1143989.
KEGGi xft:PD1267.
PATRICi 24150635. VBIXylFas71109_1624.

Phylogenomic databases

eggNOGi COG0141.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci XFAS183190:GIX4-1267-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative analyses of the complete genome sequences of Pierce's disease and citrus variegated chlorosis strains of Xylella fastidiosa."
    Van Sluys M.A., de Oliveira M.C., Monteiro-Vitorello C.B., Miyaki C.Y., Furlan L.R., Camargo L.E.A., da Silva A.C.R., Moon D.H., Takita M.A., Lemos E.G.M., Machado M.A., Ferro M.I.T., da Silva F.R., Goldman M.H.S., Goldman G.H., Lemos M.V.F., El-Dorry H., Tsai S.M.
    , Carrer H., Carraro D.M., de Oliveira R.C., Nunes L.R., Siqueira W.J., Coutinho L.L., Kimura E.T., Ferro E.S., Harakava R., Kuramae E.E., Marino C.L., Giglioti E., Abreu I.L., Alves L.M.C., do Amaral A.M., Baia G.S., Blanco S.R., Brito M.S., Cannavan F.S., Celestino A.V., da Cunha A.F., Fenille R.C., Ferro J.A., Formighieri E.F., Kishi L.T., Leoni S.G., Oliveira A.R., Rosa V.E. Jr., Sassaki F.T., Sena J.A.D., de Souza A.A., Truffi D., Tsukumo F., Yanai G.M., Zaros L.G., Civerolo E.L., Simpson A.J.G., Almeida N.F. Jr., Setubal J.C., Kitajima J.P.
    J. Bacteriol. 185:1018-1026(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Temecula1 / ATCC 700964.

Entry informationi

Entry nameiHISX_XYLFT
AccessioniPrimary (citable) accession number: Q87C29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2003
Last sequence update: June 6, 2003
Last modified: May 14, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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