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Q87C28

- HIS1_XYLFT

UniProt

Q87C28 - HIS1_XYLFT

Protein

ATP phosphoribosyltransferase

Gene

hisG

Organism
Xylella fastidiosa (strain Temecula1 / ATCC 700964)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (16 Jun 2003)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.UniRule annotation

    Catalytic activityi

    1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Enzyme regulationi

    Feedback inhibited by histidine.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ATP phosphoribosyltransferase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciXFAS183190:GIX4-1268-MONOMER.
    UniPathwayiUPA00031; UER00006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP phosphoribosyltransferaseUniRule annotation (EC:2.4.2.17UniRule annotation)
    Short name:
    ATP-PRTUniRule annotation
    Short name:
    ATP-PRTaseUniRule annotation
    Gene namesi
    Name:hisGUniRule annotation
    Ordered Locus Names:PD_1268
    OrganismiXylella fastidiosa (strain Temecula1 / ATCC 700964)
    Taxonomic identifieri183190 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella
    ProteomesiUP000002516: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 304304ATP phosphoribosyltransferasePRO_0000151876Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi183190.PD1268.

    Structurei

    3D structure databases

    ProteinModelPortaliQ87C28.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP phosphoribosyltransferase family. Long subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0040.
    KOiK00765.
    OMAiSWRESRD.
    OrthoDBiEOG66MQT3.

    Family and domain databases

    HAMAPiMF_00079. HisG_Long.
    InterProiIPR013820. ATP_PRibTrfase_cat.
    IPR018198. ATP_PRibTrfase_CS.
    IPR001348. ATP_PRibTrfase_HisG.
    IPR020621. ATP_PRibTrfase_HisG_long.
    IPR013115. HisG_C.
    [Graphical view]
    PANTHERiPTHR21403. PTHR21403. 1 hit.
    PfamiPF01634. HisG. 1 hit.
    PF08029. HisG_C. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00070. hisG. 1 hit.
    TIGR03455. HisG_C-term. 1 hit.
    PROSITEiPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q87C28-1 [UniParc]FASTAAdd to Basket

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    MSASTALPVR DRLRIAIQKS GRLTEPARRL LTACGLSWRQ SRDKLFCYGE    50
    SLPVDLLLVR DDDIPGLIAQ GVCDLGIVGR NELDEQAASR RRNGLPVPYQ 100
    TLRGLHFGQC RLMLAVPEEW EWQDISQLTG KRIATSYPAI LADWLQTHHI 150
    AAQIVELSGS VEIAPRLGTA DLICDLVSSG ATLAAHQLKP VIQIMESQAV 200
    LAGMICQPAD ARAGLLAMLL RRIDGMVNLR DSNLLMFRAF QEHLDALTRL 250
    LPDADPLVQL PDDGSGTLRV QTMCHGTITW QRLEELERAG AQGLMVLTVE 300
    RSLA 304
    Length:304
    Mass (Da):33,468
    Last modified:June 16, 2003 - v1
    Checksum:i88E37467DA88AFC8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009442 Genomic DNA. Translation: AAO29117.1.
    RefSeqiNP_779468.1. NC_004556.1.

    Genome annotation databases

    EnsemblBacteriaiAAO29117; AAO29117; PD_1268.
    GeneIDi1143990.
    KEGGixft:PD1268.
    PATRICi24150637. VBIXylFas71109_1625.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009442 Genomic DNA. Translation: AAO29117.1 .
    RefSeqi NP_779468.1. NC_004556.1.

    3D structure databases

    ProteinModelPortali Q87C28.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 183190.PD1268.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO29117 ; AAO29117 ; PD_1268 .
    GeneIDi 1143990.
    KEGGi xft:PD1268.
    PATRICi 24150637. VBIXylFas71109_1625.

    Phylogenomic databases

    eggNOGi COG0040.
    KOi K00765.
    OMAi SWRESRD.
    OrthoDBi EOG66MQT3.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00006 .
    BioCyci XFAS183190:GIX4-1268-MONOMER.

    Family and domain databases

    HAMAPi MF_00079. HisG_Long.
    InterProi IPR013820. ATP_PRibTrfase_cat.
    IPR018198. ATP_PRibTrfase_CS.
    IPR001348. ATP_PRibTrfase_HisG.
    IPR020621. ATP_PRibTrfase_HisG_long.
    IPR013115. HisG_C.
    [Graphical view ]
    PANTHERi PTHR21403. PTHR21403. 1 hit.
    Pfami PF01634. HisG. 1 hit.
    PF08029. HisG_C. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00070. hisG. 1 hit.
    TIGR03455. HisG_C-term. 1 hit.
    PROSITEi PS01316. ATP_P_PHORIBOSYLTR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative analyses of the complete genome sequences of Pierce's disease and citrus variegated chlorosis strains of Xylella fastidiosa."
      Van Sluys M.A., de Oliveira M.C., Monteiro-Vitorello C.B., Miyaki C.Y., Furlan L.R., Camargo L.E.A., da Silva A.C.R., Moon D.H., Takita M.A., Lemos E.G.M., Machado M.A., Ferro M.I.T., da Silva F.R., Goldman M.H.S., Goldman G.H., Lemos M.V.F., El-Dorry H., Tsai S.M.
      , Carrer H., Carraro D.M., de Oliveira R.C., Nunes L.R., Siqueira W.J., Coutinho L.L., Kimura E.T., Ferro E.S., Harakava R., Kuramae E.E., Marino C.L., Giglioti E., Abreu I.L., Alves L.M.C., do Amaral A.M., Baia G.S., Blanco S.R., Brito M.S., Cannavan F.S., Celestino A.V., da Cunha A.F., Fenille R.C., Ferro J.A., Formighieri E.F., Kishi L.T., Leoni S.G., Oliveira A.R., Rosa V.E. Jr., Sassaki F.T., Sena J.A.D., de Souza A.A., Truffi D., Tsukumo F., Yanai G.M., Zaros L.G., Civerolo E.L., Simpson A.J.G., Almeida N.F. Jr., Setubal J.C., Kitajima J.P.
      J. Bacteriol. 185:1018-1026(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Temecula1 / ATCC 700964.

    Entry informationi

    Entry nameiHIS1_XYLFT
    AccessioniPrimary (citable) accession number: Q87C28
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2003
    Last sequence update: June 16, 2003
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3