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Protein

Beta-hexosaminidase

Gene

nagZ

Organism
Xylella fastidiosa (strain Temecula1 / ATCC 700964)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.UniRule annotation

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.UniRule annotation

Pathwayi: peptidoglycan recycling

This protein is involved in the pathway peptidoglycan recycling, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan recycling and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei60SubstrateUniRule annotation1
Binding sitei68SubstrateUniRule annotation1
Binding sitei133SubstrateUniRule annotation1
Sitei174Important for catalytic activityUniRule annotation1
Active sitei176Proton donor/acceptorUniRule annotation1
Active sitei247NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00544.

Protein family/group databases

CAZyiGH3. Glycoside Hydrolase Family 3.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidaseUniRule annotation (EC:3.2.1.52UniRule annotation)
Alternative name(s):
Beta-N-acetylhexosaminidaseUniRule annotation
N-acetyl-beta-glucosaminidaseUniRule annotation
Gene namesi
Name:nagZUniRule annotation
Ordered Locus Names:PD_1383
OrganismiXylella fastidiosa (strain Temecula1 / ATCC 700964)
Taxonomic identifieri183190 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella
Proteomesi
  • UP000002516 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002108051 – 335Beta-hexosaminidaseAdd BLAST335

Structurei

3D structure databases

ProteinModelPortaliQ87BR5.
SMRiQ87BR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni163 – 164Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.UniRule annotation

Phylogenomic databases

KOiK01207.
OMAiHKETPRD.

Family and domain databases

Gene3Di3.20.20.300. 1 hit.
HAMAPiMF_00364. NagZ. 1 hit.
InterProiView protein in InterPro
IPR022956. Beta_hexosaminidase_bac.
IPR019800. Glyco_hydro_3_AS.
IPR001764. Glyco_hydro_3_N.
IPR036962. Glyco_hydro_3_N_sf.
IPR017853. Glycoside_hydrolase_SF.
PfamiView protein in Pfam
PF00933. Glyco_hydro_3. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiView protein in PROSITE
PS00775. GLYCOSYL_HYDROL_F3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q87BR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLIGVAGTT LSAQEVDWLQ DDAVAGVVLF KRNFASRAQI VELSAALREA
60 70 80 90 100
APRPLLLAVD QEGGRVQRFH EGYSALPPLQ GIGALYVRDP EAALELAFEH
110 120 130 140 150
AWLMASEVRA SGVDLSFAPV VDLGRGNRAI GDRAFSDDPH VVAAFAKAYV
160 170 180 190 200
QGMHAAGMPV TLKHFPGHGS VLEDTHVDLA VDVRALETLE SEDLVPFAAG
210 220 230 240 250
IAAGADAVMM AHVVYPNVAP EPAGFSAHWI EVILRGRMGF RGVVFSDDIG
260 270 280 290 300
MAAVRGVGGV VGCVHAHLDA GCDVVLVCHP ELVNDALSAV AGRRSNTAAL
310 320 330
IGLIGRGVLG WDGLLADVRY GSIQSHLFER FGTST
Length:335
Mass (Da):35,294
Last modified:June 16, 2003 - v1
Checksum:iD226818D0FF0C8D1
GO

Sequence cautioni

The sequence AAO29230 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009442 Genomic DNA. Translation: AAO29230.1. Different initiation.
RefSeqiWP_004091030.1. NC_004556.1.

Genome annotation databases

EnsemblBacteriaiAAO29230; AAO29230; PD_1383.
KEGGixft:PD_1383.

Similar proteinsi

Entry informationi

Entry nameiNAGZ_XYLFT
AccessioniPrimary (citable) accession number: Q87BR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 16, 2003
Last modified: October 25, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families