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Q87B94 (PUR5_XYLFT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine cyclo-ligase

EC=6.3.3.1
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene names
Name:purM
Ordered Locus Names:PD_1564
OrganismXylella fastidiosa (strain Temecula1 / ATCC 700964) [Complete proteome] [HAMAP]
Taxonomic identifier183190 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP-Rule MF_00741

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP-Rule MF_00741

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00741.

Sequence similarities

Belongs to the AIR synthase family.

Ontologies

Keywords
   Biological processPurine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process'de novo' IMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoribosylformylglycinamidine cyclo-ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 351351Phosphoribosylformylglycinamidine cyclo-ligase HAMAP-Rule MF_00741
PRO_0000148277

Sequences

Sequence LengthMass (Da)Tools
Q87B94 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 313C7710F2ED19D7

FASTA35137,580
        10         20         30         40         50         60 
MTTPPPPSTT PLTYRDAGVD IDAGNALVER IKPLVKRTFR PEVMSGLGGF GALFNLAGKY 

        70         80         90        100        110        120 
KEPVLVSGTD GVGTKLKLAQ QLNRHNTIGI DLVAMCVNDV LVQGAEPLFF LDYFATGKLD 

       130        140        150        160        170        180 
IDTATAVISG IALGCEQSGC ALIGGETAEM PDMYPPGEYD LAGFCVAAVE KSQLLDGSQV 

       190        200        210        220        230        240 
REDDVLIGIA SSGPHSNGYS LIRRIYERAG SPADLDIHGT RLIDTLMAPT ALYVKPILKL 

       250        260        270        280        290        300 
LHTHSDAIHA MAHITGGGLT ENIIRVIPPN LGLRIDANAW TQPPVFQWLQ REGALADTEM 

       310        320        330        340        350 
WRTFNCGIGF VLVATPNQVA PLGQALDNQG LAHWQIGRVV TPVDNERVHI G 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE009442 Genomic DNA. Translation: AAO29406.1.
RefSeqNP_779757.1. NC_004556.1.

3D structure databases

ProteinModelPortalQ87B94.
SMRQ87B94. Positions 10-350.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING183190.PD1564.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO29406; AAO29406; PD_1564.
GeneID1142906.
KEGGxft:PD1564.
PATRIC24151380. VBIXylFas71109_1994.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0150.
KOK01933.
OMAEFEMYRT.
OrthoDBEOG61CM1V.

Enzyme and pathway databases

BioCycXFAS183190:GIX4-1564-MONOMER.
UniPathwayUPA00074; UER00129.

Family and domain databases

Gene3D3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPMF_00741_B. AIRS_B.
InterProIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsTIGR00878. purM. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR5_XYLFT
AccessionPrimary (citable) accession number: Q87B94
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways