Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q87AJ1 (PDXA_XYLFT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
4-hydroxythreonine-4-phosphate dehydrogenase

EC=1.1.1.262
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenase
Gene names
Name:pdxA
Ordered Locus Names:PD_1834
OrganismXylella fastidiosa (strain Temecula1 / ATCC 700964) [Complete proteome] [HAMAP]
Taxonomic identifier183190 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella

Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) By similarity. HAMAP-Rule MF_00536

Catalytic activity

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH. HAMAP-Rule MF_00536

Cofactor

Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt By similarity.

Pathway

Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 4/5. HAMAP-Rule MF_00536

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00536

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00536.

Miscellaneous

The active site is located at the dimer interface By similarity.

Sequence similarities

Belongs to the PdxA family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3303304-hydroxythreonine-4-phosphate dehydrogenase HAMAP-Rule MF_00536
PRO_0000188840

Sites

Metal binding1611Divalent metal cation; shared with dimeric partner By similarity
Metal binding2061Divalent metal cation; shared with dimeric partner By similarity
Metal binding2611Divalent metal cation; shared with dimeric partner By similarity
Binding site1331Substrate By similarity
Binding site2691Substrate By similarity
Binding site2781Substrate By similarity
Binding site2871Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q87AJ1 [UniParc].

Last modified June 16, 2003. Version 1.
Checksum: 103FA63B9F0C1CF9

FASTA33034,654
        10         20         30         40         50         60 
MLHPALALVP GEPAGVGPEL CVRLVQQPRQ DCRLVAFADP ATLQAAAAAL DLPLRLLPPE 

        70         80         90        100        110        120 
ALPERPGDLP IQAHCHVHPT RFGHPDPANA PAVIAALCEA ASHCVHGVLH GIVTGPVHKA 

       130        140        150        160        170        180 
VINQSGIHYT GTTELLAAQA ECDVVMMLAN PHLRVALVTT HLPLRDVPDA ITAALLERCL 

       190        200        210        220        230        240 
RIVNTAMCGD FGIATPRIAV LGLNPHAGEE GYLGREELDV VIPVLQRLRA EGMVLLGPLS 

       250        260        270        280        290        300 
ADTAFLPTKL IGYDAVVAMY HDQGLPVLKH SGFEQAVNIT LGLPYPRVAV DHGTALDLAG 

       310        320        330 
RGVADPSSLF AATALCARLA ASRALLSVRS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE009442 Genomic DNA. Translation: AAO29666.1.
RefSeqNP_780017.1. NC_004556.1.

3D structure databases

ProteinModelPortalQ87AJ1.
SMRQ87AJ1. Positions 5-324.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING183190.PD1834.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO29666; AAO29666; PD_1834.
GeneID1143176.
KEGGxft:PD1834.
PATRIC24152146. VBIXylFas71109_2371.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1995.
KOK00097.
OMADTLFQDK.
OrthoDBEOG6GN6ZC.

Enzyme and pathway databases

BioCycXFAS183190:GIX4-1834-MONOMER.
UniPathwayUPA00244; UER00312.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
HAMAPMF_00536. PdxA.
InterProIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00557. pdxA. 1 hit.
ProtoNetSearch...

Entry information

Entry namePDXA_XYLFT
AccessionPrimary (citable) accession number: Q87AJ1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 16, 2003
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways