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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Xylella fastidiosa (strain Temecula1 / ATCC 700964)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei74S-adenosyl-L-methionineUniRule annotation1
Binding sitei99S-adenosyl-L-methionineUniRule annotation1
Binding sitei126S-adenosyl-L-methionineUniRule annotation1
Active sitei149By similarity1
Binding sitei149S-adenosyl-L-methionineUniRule annotation1
Binding sitei153SubstrateUniRule annotation1
Binding sitei185SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:PD_1876
OrganismiXylella fastidiosa (strain Temecula1 / ATCC 700964)
Taxonomic identifieri183190 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXylella
Proteomesi
  • UP000002516 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001714271 – 243tRNA (guanine-N(7)-)-methyltransferaseAdd BLAST243

Proteomic databases

PRIDEiQ87AE9

Structurei

3D structure databases

ProteinModelPortaliQ87AE9
SMRiQ87AE9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni222 – 225Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

KOiK03439
OMAiPDPWHKS

Family and domain databases

HAMAPiMF_01057 tRNA_methyltr_TrmB, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00091 TIGR00091, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

Q87AE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLLSSDGVQ VLPRPFTLNE RRREVRSFVL RQGHFTPAQK RAFDHYWPRF
60 70 80 90 100
GVDFIGQLRD LDVLFGRSAP KVLEVGFGNG AALRFAAQHE PRYDYIGIEV
110 120 130 140 150
YAPGVGRLLN GLAEDGSRHV RLYHYDAVEV LNKEIVDGAL DEIRIYFPDP
160 170 180 190 200
WHKKRHHKRR LIQPLFATLL VRKLRVGGCL HMATDWADYA EQMWDVLDAT
210 220 230 240
PGLVNRAGLR GQVPCPDWRV QTRFERRGQN LGHRVWNLLY DRV
Length:243
Mass (Da):28,191
Last modified:June 16, 2003 - v1
Checksum:i7C0C67CB73C1990C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009442 Genomic DNA Translation: AAO29708.1

Genome annotation databases

EnsemblBacteriaiAAO29708; AAO29708; PD_1876
KEGGixft:PD_1876

Similar proteinsi

Entry informationi

Entry nameiTRMB_XYLFT
AccessioniPrimary (citable) accession number: Q87AE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: June 16, 2003
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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