Q87AA7 (COAE_XYLFT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dephospho-CoA kinase
EC=2.7.1.24

Alternative name(s):
Dephosphocoenzyme A kinase

Gene names

Name:	coaE
Ordered Locus Names:	PD_1921

Organism

Xylella fastidiosa (strain Temecula1 / ATCC 700964) [Complete proteome] [HAMAP]

Taxonomic identifier

183190 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xylella › Xylella fastidiosa

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A By similarity. HAMAP-Rule MF_00376
Catalytic activity	ATP + 3'-dephospho-CoA = ADP + CoA. HAMAP-Rule MF_00376
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5. HAMAP-Rule MF_00376
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the CoaE family. Contains 1 DPCK (dephospho-CoA kinase) domain.
Sequence caution	The sequence AAO29751.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP dephospho-CoA kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 207	207	Dephospho-CoA kinase HAMAP-Rule MF_00376		PRO_0000173037
Regions
	Nucleotide binding	10 – 17	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q87AA7 [UniParc]. Last modified June 16, 2003. Version 1. Checksum: B3BE20D66ADEA58E	FASTA	207	22,253
	10 20 30 40 50 60 MSVYAVGLTG GVACGKSLLA QLFEALNTTV VDADTIARQV VEPGPVLNCI VARFGSKILR 70 80 90 100 110 120 ADGCLDRRFL RQRVFADVAE RKALEAIVHP VIRARLKQAA AAAAGPYVLV VIPLLAEAGG 130 140 150 160 170 180 RIGYPWLQRI LVVDAIPEVQ HARLMQRDSI DAEQASLMIA AQIGRKERLA IADDIVFNDG 190 200 DPAHLGGQVC NLDARYRALA SVFSDVD

References

[1]

"Comparative analyses of the complete genome sequences of Pierce's disease and citrus variegated chlorosis strains of Xylella fastidiosa." Van Sluys M.A., de Oliveira M.C., Monteiro-Vitorello C.B., Miyaki C.Y., Furlan L.R., Camargo L.E.A., da Silva A.C.R., Moon D.H., Takita M.A., Lemos E.G.M., Machado M.A., Ferro M.I.T., da Silva F.R., Goldman M.H.S., Goldman G.H., Lemos M.V.F., El-Dorry H., Tsai S.M. , Carrer H., Carraro D.M., de Oliveira R.C., Nunes L.R., Siqueira W.J., Coutinho L.L., Kimura E.T., Ferro E.S., Harakava R., Kuramae E.E., Marino C.L., Giglioti E., Abreu I.L., Alves L.M.C., do Amaral A.M., Baia G.S., Blanco S.R., Brito M.S., Cannavan F.S., Celestino A.V., da Cunha A.F., Fenille R.C., Ferro J.A., Formighieri E.F., Kishi L.T., Leoni S.G., Oliveira A.R., Rosa V.E. Jr., Sassaki F.T., Sena J.A.D., de Souza A.A., Truffi D., Tsukumo F., Yanai G.M., Zaros L.G., Civerolo E.L., Simpson A.J.G., Almeida N.F. Jr., Setubal J.C., Kitajima J.P. J. Bacteriol. 185:1018-1026(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Temecula1 / ATCC 700964.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE009442 Genomic DNA. Translation: AAO29751.1. Different initiation.
RefSeq	NP_780102.1. NC_004556.1.
3D structure databases
ProteinModelPortal	Q87AA7.
ModBase	Search...
Protein-protein interaction databases
STRING	183190.PD1921.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAO29751; AAO29751; PD_1921.
GeneID	1143263.
KEGG	xft:PD1921.
PATRIC	24152373. VBIXylFas71109_2482.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0237.
KO	K00859.
OMA	QRLACQM.
ProtClustDB	PRK00081.
Enzyme and pathway databases
UniPathway	UPA00241; UER00356.
Family and domain databases
HAMAP	MF_00376. Dephospho_CoA_kinase.
InterPro	IPR001977. Depp_CoAkinase. [Graphical view]
Pfam	PF01121. CoaE. 1 hit. [Graphical view]
TIGRFAMs	TIGR00152. TIGR00152. 1 hit.
PROSITE	PS51219. DPCK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COAE_XYLFT

Accession

Primary (citable) accession number: Q87AA7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 16, 2003
Last sequence update:	June 16, 2003
Last modified:	May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program