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Q877L9

- EFTU_CLOTE

UniProt

Q877L9 - EFTU_CLOTE

Protein

Elongation factor Tu

Gene

tufA

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Organism
Clostridium tetani (strain Massachusetts / E88)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    • Comment

    Functioni

    This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi19 – 268GTPUniRule annotation
    Nucleotide bindingi81 – 855GTPUniRule annotation
    Nucleotide bindingi136 – 1394GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: InterPro
    2. GTP binding Source: UniProtKB-HAMAP
    3. translation elongation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Elongation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCTET212717:GJAM-2410-MONOMER.
    CTET212717:GJAM-2420-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Elongation factor TuUniRule annotation
    Short name:
    EF-TuUniRule annotation
    Gene namesi
    Name:tufAUniRule annotation
    Ordered Locus Names:CTC_02602
    AND
    Name:tufBUniRule annotation
    Ordered Locus Names:CTC_02616
    OrganismiClostridium tetani (strain Massachusetts / E88)
    Taxonomic identifieri212717 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000001412: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 397397Elongation factor TuPRO_0000091314Add
    BLAST

    Proteomic databases

    PRIDEiQ877L9.

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi212717.CTC02616.

    Structurei

    3D structure databases

    ProteinModelPortaliQ877L9.
    SMRiQ877L9. Positions 2-397.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini10 – 206197tr-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni19 – 268G1By similarity
    Regioni60 – 645G2By similarity
    Regioni81 – 844G3By similarity
    Regioni136 – 1394G4By similarity
    Regioni174 – 1763G5By similarity

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0050.
    KOiK02358.
    OMAiISAPAAC.
    OrthoDBiEOG6R5C6X.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00118_B. EF_Tu_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    IPR004541. Transl_elong_EFTu/EF1A_bac/org.
    IPR004160. Transl_elong_EFTu/EF1A_C.
    [Graphical view]
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF03143. GTP_EFTU_D3. 1 hit.
    [Graphical view]
    PRINTSiPR00315. ELONGATNFCT.
    SUPFAMiSSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS00301. G_TR_1. 1 hit.
    PS51722. G_TR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q877L9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKEKFERSK PHVNIGTIGH VDHGKTTLTA AITTILGHKG FAKAFKYDEI    50
    DKAPEEKERG ITISTSHVEY ETENRHYAHV DCPGHADYVK NMITGAAQMD 100
    GAILVVSAAD GPMPQTREHI LLASRVGVEH IVVFLNKADQ VDDAELIELV 150
    EMEVRELMNE YGFPGDDAPV VVGSALKALE NPEDDAATQC IMDLMAAVDE 200
    YIPTPERATD KPFLMPVEDI FTITGRGTVA TGRVERGILK VGDEIEIVGL 250
    SDESKKSVIT GIEMFRKLLD EAQAGDNIGA LLRGVQRDEI QRGQVLAATG 300
    SVKPHKSFTG QVYVLKKEEG GRHTPFFNGY RPQFYFRTTD VTGSIALPEG 350
    VEMVMPGDHI DMKVELITRV AMDEGLRFAI REGGRTVGSG VVSEITE 397
    Length:397
    Mass (Da):43,447
    Last modified:June 1, 2003 - v1
    Checksum:iC11B97007670AD29
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015927 Genomic DNA. Translation: AAO37057.1.
    AE015927 Genomic DNA. Translation: AAO37067.1.
    RefSeqiNP_783120.1. NC_004557.1.
    NP_783130.1. NC_004557.1.
    WP_011100718.1. NC_004557.1.

    Genome annotation databases

    EnsemblBacteriaiAAO37057; AAO37057; CTC_02602.
    AAO37067; AAO37067; CTC_02616.
    GeneIDi1059595.
    1059735.
    KEGGictc:CTC02602.
    ctc:CTC02616.
    PATRICi19513333. VBICloTet101274_2697.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE015927 Genomic DNA. Translation: AAO37057.1 .
    AE015927 Genomic DNA. Translation: AAO37067.1 .
    RefSeqi NP_783120.1. NC_004557.1.
    NP_783130.1. NC_004557.1.
    WP_011100718.1. NC_004557.1.

    3D structure databases

    ProteinModelPortali Q877L9.
    SMRi Q877L9. Positions 2-397.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 212717.CTC02616.

    Proteomic databases

    PRIDEi Q877L9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO37057 ; AAO37057 ; CTC_02602 .
    AAO37067 ; AAO37067 ; CTC_02616 .
    GeneIDi 1059595.
    1059735.
    KEGGi ctc:CTC02602.
    ctc:CTC02616.
    PATRICi 19513333. VBICloTet101274_2697.

    Phylogenomic databases

    eggNOGi COG0050.
    KOi K02358.
    OMAi ISAPAAC.
    OrthoDBi EOG6R5C6X.

    Enzyme and pathway databases

    BioCyci CTET212717:GJAM-2410-MONOMER.
    CTET212717:GJAM-2420-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00118_B. EF_Tu_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    IPR004541. Transl_elong_EFTu/EF1A_bac/org.
    IPR004160. Transl_elong_EFTu/EF1A_C.
    [Graphical view ]
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF03143. GTP_EFTU_D3. 1 hit.
    [Graphical view ]
    PRINTSi PR00315. ELONGATNFCT.
    SUPFAMi SSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00485. EF-Tu. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS00301. G_TR_1. 1 hit.
    PS51722. G_TR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Massachusetts / E88.

    Entry informationi

    Entry nameiEFTU_CLOTE
    AccessioniPrimary (citable) accession number: Q877L9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3