Q877I0 (DEOC_PYRKO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyribose-phosphate aldolase
Short name=DERA
EC=4.1.2.4

Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase
Phosphodeoxyriboaldolase
Short name=Deoxyriboaldolase

Gene names

Name:	deoC
Ordered Locus Names:	TK2104

Organism

Pyrococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Thermococcus kodakaraensis (strain KOD1))

Taxonomic identifier

69014 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Thermococcus

Protein attributes

Sequence length	224 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate By similarity. HAMAP MF_00114
Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00114
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP MF_00114
Subcellular location	Cytoplasm By similarity HAMAP MF_00114.
Sequence similarities	Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 224	224	Deoxyribose-phosphate aldolase HAMAP MF_00114		PRO_0000057291
Sites
	Active site	158	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	187	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q877I0 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: B3EFEC0569702F4A	FASTA	224	24,506
	10 20 30 40 50 60 MNKREIARYI DQTNLKPYAT KEDIIKLCDE AIEYGFYAVC VNPYRVKLAK DYLREKNADV 70 80 90 100 110 120 KVASVIGFPL GATPTEVKVF EAKRALEDGA DELDMVINIG ALKDKDYEYV KNDIAEVVKV 130 140 150 160 170 180 AHERGAKVKV IIETCYLTEE EKVKACELAK EAGADFVKTS TGFGTGGATV EDVRLMRKVV 190 200 210 220 GPEMGVKAAG GIRTYEQALE MIEAGANRIG TSSGVKIVEG APDE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Presence of a novel phosphopentomutase and a 2-deoxyribose 5-phosphate aldolase reveals a metabolic link between pentoses and central carbon metabolism in the hyperthermophilic archaeon Thermococcus kodakaraensis." Rashid N., Imanaka H., Fukui T., Atomi H., Imanaka T. J. Bacteriol. 186:4185-4191(2004) [PubMed: 15205420] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC BAA-918 / JCM 12380 / KOD1.
[2]	"Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes." Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T. Genome Res. 15:352-363(2005) [PubMed: 15710748] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-918 / JCM 12380 / KOD1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB092961 Genomic DNA. Translation: BAC67708.1. AP006878 Genomic DNA. Translation: BAD86293.1.
RefSeq	YP_184517.1. NC_006624.1.
3D structure databases
ProteinModelPortal	Q877I0.
SMR	Q877I0. Positions 5-223.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBPYRT00000006571; EBPYRP00000006352; EBPYRG00000006570.
GeneID	3233914.
GenomeReviews	Gene locus TK2104 in contig AP006878_GR.
KEGG	tko:TK2104.
NMPDR	fig|69014.3.peg.2105.
Phylogenomic databases
eggNOG	arNOG10952.
HOGENOM	HBG636421.
OMA	IDHTNLK.
PhylomeDB	Q877I0.
ProtClustDB	CLSK2395926.
Enzyme and pathway databases
BioCyc	TKOD69014:TK2104-MONOMER.
Family and domain databases
HAMAP	MF_00114. DeoC_type1. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. IPR022979. Deoxyribose_phosphate_aldo_1. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01619.
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. DeoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOC_PYRKO

Accession

Primary (citable) accession number: Q877I0

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2003
Last sequence update:	June 1, 2003
Last modified:	November 16, 2011
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program