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Q877G8

- Q877G8_METMI

UniProt

Q877G8 - Q877G8_METMI

Protein
Submitted name:

Chaperonin

Gene
N/A
Organism
Methanococcus maripaludis (Methanococcus deltae)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei59 – 591ADPImported
    Binding sitei66 – 661Sulfate 2
    Binding sitei83 – 831Sulfate 2
    Binding sitei386 – 3861ATPanalogImported
    Binding sitei404 – 4041ADP; via amide nitrogenImported
    Binding sitei404 – 4041ATPanalog; via amide nitrogenImported
    Binding sitei474 – 4741ATPanalogImported
    Binding sitei490 – 4901ADPImported
    Binding sitei490 – 4901ATPanalogImported

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi38 – 414ADPImported
    Nucleotide bindingi38 – 403ATPanalogImported
    Nucleotide bindingi59 – 613ATPanalogImported
    Nucleotide bindingi91 – 955ADPImported
    Nucleotide bindingi91 – 955ATPanalogImported
    Nucleotide bindingi160 – 1612ADPImported
    Nucleotide bindingi160 – 1612ATPanalogImported

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. protein folding Source: InterPro

    Keywords - Molecular functioni

    ChaperoneUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    ChaperoninImported
    OrganismiMethanococcus maripaludis (Methanococcus deltae)Imported
    Taxonomic identifieri39152 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-29771N.
    MINTiMINT-8373072.
    STRINGi267377.MMP1515.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3IYFelectron microscopy8.00A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P1-240[»]
    A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P268-543[»]
    3IZHelectron microscopy11.00A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P7-519[»]
    3IZIelectron microscopy6.70A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P7-519[»]
    3IZJelectron microscopy6.90A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P7-519[»]
    3IZKelectron microscopy4.90A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P268-519[»]
    A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P7-240[»]
    3IZLelectron microscopy6.20A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P268-519[»]
    A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P7-240[»]
    3IZMelectron microscopy7.20A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P7-519[»]
    3IZNelectron microscopy6.40A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P268-519[»]
    A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P7-240[»]
    3J02electron microscopy8.00A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P269-519[»]
    A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P7-240[»]
    3J03electron microscopy4.80A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P269-519[»]
    A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P7-240[»]
    3J3Xelectron microscopy4.30A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P1-532[»]
    3KFBX-ray3.20A/B/C/D/E/F/G/H1-543[»]
    3KFEX-ray3.50A/B/C/D/E/F/G/H1-543[»]
    3KFKX-ray6.00A/B/C/D1-543[»]
    3LOSelectron microscopy4.30A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P1-543[»]
    3RUQX-ray2.80A/B/C/D1-543[»]
    3RUSX-ray2.34A/B/C/D1-543[»]
    3RUVX-ray2.24A/B/C/D1-543[»]
    3RUWX-ray2.70A/B/C/D1-543[»]
    ProteinModelPortaliQ877G8.
    SMRiQ877G8. Positions 7-519.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ877G8.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TCP-1 chaperonin family.UniRule annotation

    Family and domain databases

    Gene3Di1.10.560.10. 2 hits.
    3.30.260.10. 2 hits.
    3.50.7.10. 1 hit.
    InterProiIPR017998. Chaperone_TCP-1.
    IPR002194. Chaperonin_TCP-1_CS.
    IPR002423. Cpn60/TCP-1.
    IPR027409. GroEL-like_apical_dom.
    IPR027413. GROEL-like_equatorial.
    IPR027410. TCP-1-like_intermed.
    IPR012714. Thermosome_arc.
    [Graphical view]
    PANTHERiPTHR11353. PTHR11353. 1 hit.
    PfamiPF00118. Cpn60_TCP1. 1 hit.
    [Graphical view]
    PRINTSiPR00304. TCOMPLEXTCP1.
    SUPFAMiSSF48592. SSF48592. 2 hits.
    SSF52029. SSF52029. 1 hit.
    TIGRFAMsiTIGR02339. thermosome_arch. 1 hit.
    PROSITEiPS00750. TCP1_1. 1 hit.
    PS00751. TCP1_2. 1 hit.
    PS00995. TCP1_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q877G8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQQPGVLPE NMKRYMGRDA QRMNILAGRI IAETVRSTLG PKGMDKMLVD    50
    DLGDVVVTND GVTILREMSV EHPAAKMLIE VAKTQEKEVG DGTTTAVVVA 100
    GELLRKAEEL LDQNVHPTIV VKGYQAAAQK AQELLKTIAC EVGAQDKEIL 150
    TKIAMTSITG KGAEKAKEKL AEIIVEAVSA VVDDEGKVDK DLIKIEKKSG 200
    ASIDDTELIK GVLVDKERVS AQMPKKVTDA KIALLNCAIE IKETETDAEI 250
    RITDPAKLME FIEQEEKMLK DMVAEIKASG ANVLFCQKGI DDLAQHYLAK 300
    EGIVAARRVK KSDMEKLAKA TGANVITNIK DLSAQDLGDA GLVEERKISG 350
    DSMIFVEECK HPKAVTMLIR GTTEHVIEEV ARAVDDAVGV VGCTIEDGRI 400
    VSGGGSTEVE LSMKLREYAE GISGREQLAV RAFADALEVI PRTLAENAGL 450
    DAIEILVKVR AAHASNGNKC AGLNVFTGAV EDMCENGVVE PLRVKTQAIQ 500
    SAAESTEMLL RIDDVIAAEK LRGAPDMGDM GGMPGMGGMP GMM 543
    Length:543
    Mass (Da):58,215
    Last modified:June 1, 2003 - v1
    Checksum:i3ED9187B0B2EEC89
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY099402 Genomic DNA. Translation: AAM21720.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY099402 Genomic DNA. Translation: AAM21720.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3IYF electron microscopy 8.00 A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P 1-240 [» ]
    A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P 268-543 [» ]
    3IZH electron microscopy 11.00 A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P 7-519 [» ]
    3IZI electron microscopy 6.70 A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P 7-519 [» ]
    3IZJ electron microscopy 6.90 A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P 7-519 [» ]
    3IZK electron microscopy 4.90 A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P 268-519 [» ]
    A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P 7-240 [» ]
    3IZL electron microscopy 6.20 A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P 268-519 [» ]
    A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P 7-240 [» ]
    3IZM electron microscopy 7.20 A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P 7-519 [» ]
    3IZN electron microscopy 6.40 A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P 268-519 [» ]
    A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P 7-240 [» ]
    3J02 electron microscopy 8.00 A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P 269-519 [» ]
    A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P 7-240 [» ]
    3J03 electron microscopy 4.80 A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P 269-519 [» ]
    A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P 7-240 [» ]
    3J3X electron microscopy 4.30 A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P 1-532 [» ]
    3KFB X-ray 3.20 A/B/C/D/E/F/G/H 1-543 [» ]
    3KFE X-ray 3.50 A/B/C/D/E/F/G/H 1-543 [» ]
    3KFK X-ray 6.00 A/B/C/D 1-543 [» ]
    3LOS electron microscopy 4.30 A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P 1-543 [» ]
    3RUQ X-ray 2.80 A/B/C/D 1-543 [» ]
    3RUS X-ray 2.34 A/B/C/D 1-543 [» ]
    3RUV X-ray 2.24 A/B/C/D 1-543 [» ]
    3RUW X-ray 2.70 A/B/C/D 1-543 [» ]
    ProteinModelPortali Q877G8.
    SMRi Q877G8. Positions 7-519.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-29771N.
    MINTi MINT-8373072.
    STRINGi 267377.MMP1515.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q877G8.

    Family and domain databases

    Gene3Di 1.10.560.10. 2 hits.
    3.30.260.10. 2 hits.
    3.50.7.10. 1 hit.
    InterProi IPR017998. Chaperone_TCP-1.
    IPR002194. Chaperonin_TCP-1_CS.
    IPR002423. Cpn60/TCP-1.
    IPR027409. GroEL-like_apical_dom.
    IPR027413. GROEL-like_equatorial.
    IPR027410. TCP-1-like_intermed.
    IPR012714. Thermosome_arc.
    [Graphical view ]
    PANTHERi PTHR11353. PTHR11353. 1 hit.
    Pfami PF00118. Cpn60_TCP1. 1 hit.
    [Graphical view ]
    PRINTSi PR00304. TCOMPLEXTCP1.
    SUPFAMi SSF48592. SSF48592. 2 hits.
    SSF52029. SSF52029. 1 hit.
    TIGRFAMsi TIGR02339. thermosome_arch. 1 hit.
    PROSITEi PS00750. TCP1_1. 1 hit.
    PS00751. TCP1_2. 1 hit.
    PS00995. TCP1_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide-dependent protein folding in the type II chaperonin from the mesophilic archaeon Methanococcus maripaludis."
      Kusmierczyk A.R., Martin J.
      Biochem. J. 371:669-673(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: LLImported.
    2. "Crystal structures of a group II chaperonin reveal the open and closed states associated with the protein folding cycle."
      Pereira J.H., Ralston C.Y., Douglas N.R., Meyer D., Knee K.M., Goulet D.R., King J.A., Frydman J., Adams P.D.
      J. Biol. Chem. 285:27958-27966(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS) IN COMPLEX WITH ADP AND ATPANALOG.
    3. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (4.30 ANGSTROMS).
    4. "Dual action of ATP hydrolysis couples lid closure to substrate release into the group II chaperonin chamber."
      Douglas N.R., Reissmann S., Zhang J., Chen B., Jakana J., Kumar R., Chiu W., Frydman J.
      Cell 144:240-252(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY ELECTRON MICROSCOPY (4.90 ANGSTROMS) OF 268-519 AND 7-240.
    5. "Cryo-EM structure of a group II chaperonin in the prehydrolysis ATP-bound state leading to lid closure."
      Zhang J., Ma B., DiMaio F., Douglas N.R., Joachimiak L.A., Baker D., Frydman J., Levitt M., Chiu W.
      Structure 19:633-639(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY ELECTRON MICROSCOPY (4.80 ANGSTROMS) OF 269-519 AND 7-240.
    6. Cited for: X-RAY CRYSTALLOGRAPHY (2.24 ANGSTROMS) IN COMPLEX WITH ADP AND ATPANALOG.
    7. "Cryo-EM model validation using independent map reconstructions."
      DiMaio F., Zhang J., Chiu W., Baker D.
      Protein Sci. 22:865-868(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY ELECTRON MICROSCOPY (4.30 ANGSTROMS) OF 1-532.

    Entry informationi

    Entry nameiQ877G8_METMI
    AccessioniPrimary (citable) accession number: Q877G8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3