Q876L3 (ARE1_SACBA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sterol O-acyltransferase 1
EC=2.3.1.26

Alternative name(s):
Sterol-ester synthase 1

Gene names

Name:

ARE1

Organism

Saccharomyces bayanus (Yeast) (Saccharomyces uvarum)

Taxonomic identifier

4931 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	623 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Acyl-CoA + cholesterol = CoA + cholesterol ester.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Acyltransferase Transferase
Gene Ontology (GO)
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cholesterol O-acyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 623	623	Sterol O-acyltransferase 1		PRO_0000207647
Regions
	Transmembrane	195 – 215	21	Helical; Potential
	Transmembrane	242 – 262	21	Helical; Potential
	Transmembrane	277 – 297	21	Helical; Potential
	Transmembrane	384 – 404	21	Helical; Potential
	Transmembrane	422 – 442	21	Helical; Potential
	Transmembrane	548 – 568	21	Helical; Potential
	Transmembrane	603 – 623	21	Helical; Potential
Sites
	Active site	560	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q876L3 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 86635C60C4741A35	FASTA	623	71,794
	10 20 30 40 50 60 MTEAKELLQD ERFLKIQELN SAEPSKRHSV TYDNVILPQE SVEVSPRSST TSLEEPATTT 70 80 90 100 110 120 ATGVAVAAAA AAAEKKKKKK GEDGDDEQDE QAEEKYPVDP RMQKYLSHLK SKSRTRVHRK 130 140 150 160 170 180 DASKYVSFFG DVSFDPRPTL LDSAVNVPFQ TTFKGPVLEK QLKGLQQTKK GEVAAAAATA 190 200 210 220 230 240 ATAATAAAAP PGKKLESNFS GIYVFAWMFM GWIAFRSCMD YYVSHEGGFA SMEIVQYMTS 250 260 270 280 290 300 DLFTIALLDL ALFLSTFFVV FVHWLVKLGF IRWKWTGFVA VSLFELCFIP VSFPVYVYYF 310 320 330 340 350 360 HFSWVTRIFL FLHSVVLLMK AHSFAFYNGY LWDIKNELEF SSNKLNKFKE SLSPETKDIL 370 380 390 400 410 420 QKSCDFCLFE LNYQTKDNDF PNNISCSNYF MFCMFPVLVY QINYPRTSHI RWRYVLEKFC 430 440 450 460 470 480 AIMGTIFLMM VTAQIFMHPV AMRCIEYHDT PSFGGWVPAV KQWLFLLFEM IPGFSVLYML 490 500 510 520 530 540 TFYMIWDALL NCVAELTRFA DRYFYGDWWN CVSFEEFSRI WNVPVHKFLL RHVYHSSMGA 550 560 570 580 590 600 LHFSKAQATL FTFLLSAVFH EIAMFAIFKE VRGYLFLFQL SQFAWTALSN TKFLRSRPQL 610 620 SNVVFTFGVC TGPSMIMTLY LTL

References

[1]	"Yeast genome duplication was followed by asynchronous differentiation of duplicated genes." Langkjaer R.B., Cliften P.F., Johnston M., Piskur J. Nature 421:848-852(2003) [PubMed: 12594514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 623-6C.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY144798 Genomic DNA. Translation: AAO32362.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
PhylomeDB	Q876L3.
Family and domain databases
InterPro	IPR004299. MBOAT_fam. IPR014371. Oat_ACAT_DAG_ARE. [Graphical view]
PANTHER	PTHR10408. PTHR10408. 1 hit.
Pfam	PF03062. MBOAT. 1 hit. [Graphical view]
PIRSF	PIRSF000439. Oat_ACAT_DAG_ARE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARE1_SACBA

Accession

Primary (citable) accession number: Q876L3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 9, 2003
Last sequence update:	June 1, 2003
Last modified:	October 19, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program