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Q876J2

- SPR1_SACU7

UniProt

Q876J2 - SPR1_SACU7

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Protein

Sporulation-specific glucan 1,3-beta-glucosidase

Gene

SPR1

Organism
Saccharomyces uvarum (strain ATCC 76518 / CBS 7001 / CLIB 283 / NBRC 10550 / MCYC 623 / NCYC 2669 / NRRL Y-11845) (Yeast) (Saccharomyces bayanus var. uvarum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Probably involved in the processes of spore formation and contributes to ascospore thermoresistance by participating in the morphogenesis of ascospore walls. The enzyme may do this by modifying glucan linkages in the developing ascospore wall, thus strengthening it or lending it plasticity (By similarity).By similarity

Catalytic activityi

Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei233 – 2331Proton donorBy similarity
Active sitei335 – 3351NucleophileBy similarity

GO - Molecular functioni

  1. glucan exo-1,3-beta-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. cell wall organization Source: UniProtKB-KW
  3. sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Cell wall biogenesis/degradation, Sporulation

Protein family/group databases

CAZyiGH5. Glycoside Hydrolase Family 5.

Names & Taxonomyi

Protein namesi
Recommended name:
Sporulation-specific glucan 1,3-beta-glucosidase (EC:3.2.1.58)
Alternative name(s):
Exo-1,3-beta-glucanase
Gene namesi
Name:SPR1
OrganismiSaccharomyces uvarum (strain ATCC 76518 / CBS 7001 / CLIB 283 / NBRC 10550 / MCYC 623 / NCYC 2669 / NRRL Y-11845) (Yeast) (Saccharomyces bayanus var. uvarum)
Taxonomic identifieri226127 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 445425Sporulation-specific glucan 1,3-beta-glucosidasePRO_0000007897Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ876J2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001547. Glyco_hydro_5.
IPR018087. Glyco_hydro_5_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF00150. Cellulase. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00659. GLYCOSYL_HYDROL_F5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q876J2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSFKRLTTL ALSFTQLVNC NPVSPKSKDS LQFIYKEKAN VYSEANSQSI
60 70 80 90 100
REKIRGVNLG GWLVLEPYIT PSIFEAFRTN PHNDNGIPVD EYRFCQSLGY
110 120 130 140 150
EKAKERLYNH WSTFYKEEDF AKIASQGFNM VRIPVGYWAF TTLSHDPYVT
160 170 180 190 200
GEQEYFLDKA VDWARKYGLK VWIDLHGAAG SQNGFDNSGL RDSYKFLDEE
210 220 230 240 250
YLSATMKALT YILSKYSTDI YLDTVIGIEL LNEPLGPVFD MERLKNLFLK
260 270 280 290 300
PAYDYLRNKI MSKQIIVMHD AFQPYNYWDN FLNGDKEEYG VILDHHHYQV
310 320 330 340 350
FSPIELARNM NERIKIACQW GVGTLSEKHW SVAGEFSAAL TDCTKWLNGV
360 370 380 390 400
GFGARYDGTW AKGNDKSYHI GSCANNENVG LWSEERKQNT RKFIEAQLDA
410 420 430 440
FEMTGGWIMW CYKTENSIEW DVEKLIQHNL FPQPISDRKH PNQCH
Length:445
Mass (Da):51,556
Last modified:June 1, 2003 - v1
Checksum:iB22023ACDED32279
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY144819 Genomic DNA. Translation: AAO32383.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY144819 Genomic DNA. Translation: AAO32383.1 .

3D structure databases

ProteinModelPortali Q876J2.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH5. Glycoside Hydrolase Family 5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001547. Glyco_hydro_5.
IPR018087. Glyco_hydro_5_CS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF00150. Cellulase. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00659. GLYCOSYL_HYDROL_F5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Yeast genome duplication was followed by asynchronous differentiation of duplicated genes."
    Langkjaer R.B., Cliften P.F., Johnston M., Piskur J.
    Nature 421:848-852(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 623-6C / CBS 9787 / CLIB 533.

Entry informationi

Entry nameiSPR1_SACU7
AccessioniPrimary (citable) accession number: Q876J2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3