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Protein

Gag polyprotein

Gene

gag

Organism
Simian immunodeficiency virus (SIV)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Viral budding, Viral budding via the host ESCRT complexesSAAS annotation, Virus exit from host cell

Keywords - Ligandi

Metal-binding, RNA-bindingUniRule annotationSAAS annotation, Viral nucleoproteinUniRule annotation, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Gag polyproteinUniRule annotationSAAS annotation
Gene namesi
Name:gagImported
OrganismiSimian immunodeficiency virus (SIV)Imported
Taxonomic identifieri11723 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiPan troglodytes (Chimpanzee) [TaxID: 9598]

Subcellular locationi

  • Host cytoplasm SAAS annotation
  • Host nucleus SAAS annotation
  • Virion UniRule annotation
  • Host nucleus UniRule annotation
  • Host cytoplasm UniRule annotation
  • Virion UniRule annotation
  • Host cytoplasm UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid proteinUniRule annotationSAAS annotation, Host cytoplasmUniRule annotationSAAS annotation, Host nucleusUniRule annotationSAAS annotation, Virion

PTM / Processingi

Post-translational modificationi

Gag-Pol polyprotein: Specific enzymatic cleavages by the viral protease yield mature proteins.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ87621.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini413 – 428CCHC-typeInterPro annotationAdd BLAST16
Domaini435 – 449CCHC-typeInterPro annotationAdd BLAST15

Sequence similaritiesi

Belongs to the primate lentivirus group gag polyprotein family.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Zinc-fingerUniRule annotationSAAS annotation

Family and domain databases

Gene3Di1.10.1200.30. 1 hit.
1.10.150.90. 1 hit.
1.10.375.10. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR000721. Gag_p24.
IPR000071. Lentvrl_matrix_N.
IPR012344. Matrix_HIV/RSV.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
IPR010999. Retrovr_matrix.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00540. Gag_p17. 1 hit.
PF00607. Gag_p24. 1 hit.
PF00098. zf-CCHC. 2 hits.
[Graphical view]
PRINTSiPR00234. HIV1MATRIX.
SMARTiSM00343. ZnF_C2HC. 2 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
SSF47836. SSF47836. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50158. ZF_CCHC. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q87621-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAGASVLRG EKLDTWESIR LRPGGKKKYM IKHLVWARSE LQRFALSSSL
60 70 80 90 100
LETSEGCEKA IHQLSPSIEI RSPEIISLFN TICVLWCVHK GEKIKDTEQA
110 120 130 140 150
VKTVKMKVMQ TQAETGSSQT ASRGMLLRLL LLNKQWCQRH LSGEGRNYPI
160 170 180 190 200
IVDAGGIARH QPLTPRTLNA WVKCVEEKNF NPEVIPMFSA LSEGATPHDL
210 220 230 240 250
NTMLNAVGDH QGAMQVLKEV INEEAAEWDR LHPTHAGPVQ AGQLREPTGS
260 270 280 290 300
DIAGTTSTVQ EQMQWMSTPQ QNGGVPVGDI YKRWIIMGLN KVVRXYSPVS
310 320 330 340 350
ILEIKQGPKE PFRDYVDRFY KTIRAEQASQ PVKAWMTETL LIQNANPDCK
360 370 380 390 400
HILKALGTGA SLEEMLTACQ GVGGPAHKAR VLAEAMASAN NAQGTAVFLQ
410 420 430 440 450
RGNGNRGGKR PLKCFNCGKE GHTARNCKAP RRKGCWRCGQ EGHQLKNCPA
460 470 480 490 500
TNTGKVNFLG KPTPTWWGCR PGNFVQKEEV VEPTAPPIEI YQEEHKRTQK
510 520
GLKGEEELPP SYSLKSLFGK DQ
Length:522
Mass (Da):57,865
Last modified:November 1, 1996 - v1
Checksum:i2FA5C00474D0A229
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U42720 Genomic DNA. Translation: AAB47723.1.

Keywords - Coding sequence diversityi

Ribosomal frameshiftingSAAS annotation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U42720 Genomic DNA. Translation: AAB47723.1.

3D structure databases

ProteinModelPortaliQ87621.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.1200.30. 1 hit.
1.10.150.90. 1 hit.
1.10.375.10. 1 hit.
4.10.60.10. 1 hit.
InterProiIPR000721. Gag_p24.
IPR000071. Lentvrl_matrix_N.
IPR012344. Matrix_HIV/RSV.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
IPR010999. Retrovr_matrix.
IPR001878. Znf_CCHC.
[Graphical view]
PfamiPF00540. Gag_p17. 1 hit.
PF00607. Gag_p24. 1 hit.
PF00098. zf-CCHC. 2 hits.
[Graphical view]
PRINTSiPR00234. HIV1MATRIX.
SMARTiSM00343. ZnF_C2HC. 2 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
SSF47836. SSF47836. 1 hit.
SSF47943. SSF47943. 1 hit.
SSF57756. SSF57756. 1 hit.
PROSITEiPS50158. ZF_CCHC. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ87621_SIV
AccessioniPrimary (citable) accession number: Q87621
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.