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Q875Z9

- KPYK_NAUCC

UniProt

Q875Z9 - KPYK_NAUCC

Protein

Pyruvate kinase

Gene

PYK1

Organism
Naumovozyma castellii (strain ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + pyruvate = ADP + phosphoenolpyruvate.

    Cofactori

    Magnesium.By similarity
    Potassium.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei50 – 501SubstrateBy similarity
    Metal bindingi52 – 521PotassiumBy similarity
    Metal bindingi54 – 541PotassiumBy similarity
    Metal bindingi85 – 851PotassiumBy similarity
    Metal bindingi86 – 861Potassium; via carbonyl oxygenBy similarity
    Sitei241 – 2411Transition state stabilizerBy similarity
    Metal bindingi243 – 2431MagnesiumSequence Analysis
    Binding sitei266 – 2661Substrate; via amide nitrogenBy similarity
    Metal bindingi267 – 2671MagnesiumBy similarity
    Binding sitei267 – 2671Substrate; via amide nitrogenBy similarity
    Binding sitei299 – 2991SubstrateBy similarity
    Binding sitei338 – 3381ADPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. magnesium ion binding Source: InterPro
    3. potassium ion binding Source: InterPro
    4. pyruvate kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00188.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate kinase (EC:2.7.1.40)
    Short name:
    PK
    Gene namesi
    Name:PYK1
    Synonyms:CDC19
    Ordered Locus Names:NCAS_0A07590
    OrganismiNaumovozyma castellii (strain ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii)
    Taxonomic identifieri1064592 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNaumovozyma
    ProteomesiUP000001640: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 501501Pyruvate kinasePRO_0000112116Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ875Z9.
    SMRiQ875Z9. Positions 3-499.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pyruvate kinase family.Curated

    Phylogenomic databases

    KOiK00873.
    OrthoDBiEOG7M6DJC.

    Family and domain databases

    Gene3Di2.40.33.10. 1 hit.
    3.20.20.60. 2 hits.
    3.40.1380.20. 1 hit.
    InterProiIPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR011037. Pyrv_Knase-like_insert_dom.
    IPR015794. Pyrv_Knase_a/b.
    IPR018209. Pyrv_Knase_AS.
    IPR015793. Pyrv_Knase_brl.
    IPR015795. Pyrv_Knase_C.
    IPR015806. Pyrv_Knase_insert_dom.
    [Graphical view]
    PANTHERiPTHR11817. PTHR11817. 1 hit.
    PfamiPF00224. PK. 1 hit.
    PF02887. PK_C. 1 hit.
    [Graphical view]
    PRINTSiPR01050. PYRUVTKNASE.
    SUPFAMiSSF50800. SSF50800. 1 hit.
    SSF51621. SSF51621. 2 hits.
    SSF52935. SSF52935. 1 hit.
    TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
    PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q875Z9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESRLARLTT LQVTAGDNLR RTSIIGTIGP KTNNPEVLVA LRKAGLNIVR    50
    MNFSHGSYEY HQSVIENARK SEELYPGRPL AIALDTKGPE IRTGTTTGEV 100
    DYPIPPNHEM IFSTDEKYAK ACDDKVMFVD YANITKVISK GKIIYVDDGV 150
    LSFEVLEVVD GKTLKVKSLN AGKICSHKGV NLPGTDVDLP ALSEKDKADL 200
    RFGVKNGVHM VFASFIRTAQ DVLTIREVLG EDGKDIKIVV KIENQQGVNN 250
    FDEILKVTDA VMVARGDLGI EIPAPEVLAV QKKLIAKSNL AGKPVICATQ 300
    MLESMTYNPR PTRAEVSDVG NAILDGADCV MLSGETAKGN YPINAVTTMA 350
    DTALIAEQAI AYQPLYDDLR NLTPKPTSTT ETVAASAVAA VYEQKAKAII 400
    VLSTSGTTPR LVSKYRPDCP IILVTRNPRA ARFSHLSRGV FPFVYEADSV 450
    ADWTEDVELR LKFGIEKAIE MGVMKKGDTY VSIQGFKAGE GHSNTLQVSN 500
    A 501
    Length:501
    Mass (Da):54,463
    Last modified:June 1, 2003 - v1
    Checksum:i6624A308CE8A2F75
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY144916 Genomic DNA. Translation: AAO32480.1.
    HE576752 Genomic DNA. Translation: CCC67317.1.
    RefSeqiXP_003673698.1. XM_003673650.1.

    Genome annotation databases

    GeneIDi11526928.
    KEGGincs:NCAS_0A07590.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY144916 Genomic DNA. Translation: AAO32480.1 .
    HE576752 Genomic DNA. Translation: CCC67317.1 .
    RefSeqi XP_003673698.1. XM_003673650.1.

    3D structure databases

    ProteinModelPortali Q875Z9.
    SMRi Q875Z9. Positions 3-499.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 11526928.
    KEGGi ncs:NCAS_0A07590.

    Phylogenomic databases

    KOi K00873.
    OrthoDBi EOG7M6DJC.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00188 .

    Family and domain databases

    Gene3Di 2.40.33.10. 1 hit.
    3.20.20.60. 2 hits.
    3.40.1380.20. 1 hit.
    InterProi IPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR011037. Pyrv_Knase-like_insert_dom.
    IPR015794. Pyrv_Knase_a/b.
    IPR018209. Pyrv_Knase_AS.
    IPR015793. Pyrv_Knase_brl.
    IPR015795. Pyrv_Knase_C.
    IPR015806. Pyrv_Knase_insert_dom.
    [Graphical view ]
    PANTHERi PTHR11817. PTHR11817. 1 hit.
    Pfami PF00224. PK. 1 hit.
    PF02887. PK_C. 1 hit.
    [Graphical view ]
    PRINTSi PR01050. PYRUVTKNASE.
    SUPFAMi SSF50800. SSF50800. 1 hit.
    SSF51621. SSF51621. 2 hits.
    SSF52935. SSF52935. 1 hit.
    TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
    PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Yeast genome duplication was followed by asynchronous differentiation of duplicated genes."
      Langkjaer R.B., Cliften P.F., Johnston M., Piskur J.
      Nature 421:848-852(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630.
    2. "Genome sequence of Naumovozyma castellii."
      Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P., Wolfe K.H.
      Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630.

    Entry informationi

    Entry nameiKPYK_NAUCC
    AccessioniPrimary (citable) accession number: Q875Z9
    Secondary accession number(s): G0V769
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3