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Q875Z9 (KPYK_NAUCC) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pyruvate kinase

Short name=PK
EC=2.7.1.40
Gene names
Name:PYK1
Synonyms:CDC19
Ordered Locus Names:NCAS_0A07590
OrganismNaumovozyma castellii (strain ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii) [Complete proteome]
Taxonomic identifier1064592 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNaumovozyma

Protein attributes

Sequence length501 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactor

Magnesium By similarity.

Potassium By similarity.

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the pyruvate kinase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 501501Pyruvate kinase
PRO_0000112116

Sites

Metal binding521Potassium By similarity
Metal binding541Potassium By similarity
Metal binding851Potassium By similarity
Metal binding861Potassium; via carbonyl oxygen By similarity
Metal binding2431Magnesium Potential
Metal binding2671Magnesium By similarity
Binding site501Substrate By similarity
Binding site2661Substrate; via amide nitrogen By similarity
Binding site2671Substrate; via amide nitrogen By similarity
Binding site2991Substrate By similarity
Binding site3381ADP Potential
Site2411Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q875Z9 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 6624A308CE8A2F75

FASTA50154,463
        10         20         30         40         50         60 
MESRLARLTT LQVTAGDNLR RTSIIGTIGP KTNNPEVLVA LRKAGLNIVR MNFSHGSYEY 

        70         80         90        100        110        120 
HQSVIENARK SEELYPGRPL AIALDTKGPE IRTGTTTGEV DYPIPPNHEM IFSTDEKYAK 

       130        140        150        160        170        180 
ACDDKVMFVD YANITKVISK GKIIYVDDGV LSFEVLEVVD GKTLKVKSLN AGKICSHKGV 

       190        200        210        220        230        240 
NLPGTDVDLP ALSEKDKADL RFGVKNGVHM VFASFIRTAQ DVLTIREVLG EDGKDIKIVV 

       250        260        270        280        290        300 
KIENQQGVNN FDEILKVTDA VMVARGDLGI EIPAPEVLAV QKKLIAKSNL AGKPVICATQ 

       310        320        330        340        350        360 
MLESMTYNPR PTRAEVSDVG NAILDGADCV MLSGETAKGN YPINAVTTMA DTALIAEQAI 

       370        380        390        400        410        420 
AYQPLYDDLR NLTPKPTSTT ETVAASAVAA VYEQKAKAII VLSTSGTTPR LVSKYRPDCP 

       430        440        450        460        470        480 
IILVTRNPRA ARFSHLSRGV FPFVYEADSV ADWTEDVELR LKFGIEKAIE MGVMKKGDTY 

       490        500 
VSIQGFKAGE GHSNTLQVSN A 

« Hide

References

« Hide 'large scale' references
[1]"Yeast genome duplication was followed by asynchronous differentiation of duplicated genes."
Langkjaer R.B., Cliften P.F., Johnston M., Piskur J.
Nature 421:848-852(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630.
[2]"Genome sequence of Naumovozyma castellii."
Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P., Wolfe K.H.
Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY144916 Genomic DNA. Translation: AAO32480.1.
HE576752 Genomic DNA. Translation: CCC67317.1.
RefSeqXP_003673698.1. XM_003673650.1.

3D structure databases

ProteinModelPortalQ875Z9.
SMRQ875Z9. Positions 3-499.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID11526928.
KEGGncs:NCAS_0A07590.

Phylogenomic databases

KOK00873.
OrthoDBEOG7M6DJC.

Enzyme and pathway databases

UniPathwayUPA00109; UER00188.

Family and domain databases

Gene3D2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERPTHR11817. PTHR11817. 1 hit.
PfamPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSPR01050. PYRUVTKNASE.
SUPFAMSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsTIGR01064. pyruv_kin. 1 hit.
PROSITEPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPYK_NAUCC
AccessionPrimary (citable) accession number: Q875Z9
Secondary accession number(s): G0V769
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: June 1, 2003
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways