Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q875S4 (KPYK_LACK1) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Protein attributes

Sequence length501 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactor

Magnesium By similarity.

Potassium By similarity.

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the pyruvate kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 501501Pyruvate kinase
PRO_0000112117

Sites

Metal binding521Potassium By similarity
Metal binding541Potassium By similarity
Metal binding851Potassium By similarity
Metal binding861Potassium; via carbonyl oxygen By similarity
Metal binding2431Magnesium Potential
Metal binding2671Magnesium By similarity
Binding site501Substrate By similarity
Binding site2661Substrate; via amide nitrogen By similarity
Binding site2671Substrate; via amide nitrogen By similarity
Binding site2991Substrate By similarity
Binding site3381ADP Potential
Site2411Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q875S4 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 91291D046FB3174C

FASTA50154,895
        10         20         30         40         50         60 
MESRLGWLTE LQTETGANLR RTSIIGTIGP KTNNPETLVA LRKAGLNIVR MNFSHGSYEY 

        70         80         90        100        110        120 
HQSVIDNARK SEELYPGRPL AIALDTKGPE IRTGTTTNEV DYPIPPNHEM IFSIDDKYAK 

       130        140        150        160        170        180 
ACDDKVMYID YKNITKVIEK GKIIYVDDGV LSFEVLEVVD EQTLKVKSLN AGKICSHKGV 

       190        200        210        220        230        240 
NLPGTDVDLP ALSEKDKSDL RFGVKNGVHM VFASFIRTAQ DVLTIREVLG EDGKDVKIIV 

       250        260        270        280        290        300 
KIENQQGVNN FDEILKVTDG VMVARGDLGI EIPAPQVFAV QKKLIAKCNL AGKPVICATQ 

       310        320        330        340        350        360 
MLESMTYNPR PTRAEVSDVG NAVLDGADCV MLSGETAKGN YPINAVTIMA ETALIAEQAI 

       370        380        390        400        410        420 
PYVATYDDLR NFTPKPTSTT ETIAAAAVSS VFEQKAKAII VLSTTGDTPR LVSKYKPNVP 

       430        440        450        460        470        480 
IVMVTRNPRA ARFSHLYRGV FPFVYESDTE SEWTKDVESR LNFGIAKAKE FGMLKEGDTI 

       490        500 
VTIQGFAAGV GHSNTLRVLT V 

« Hide

References

[1]"Yeast genome duplication was followed by asynchronous differentiation of duplicated genes."
Langkjaer R.B., Cliften P.F., Johnston M., Piskur J.
Nature 421:848-852(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 58438 / CBS 3082 / CCRC 21498 / NBRC 1685 / JCM 7257 / NCYC 543 / NRRL Y-12651.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY144995 Genomic DNA. Translation: AAO32558.1.

3D structure databases

ProteinModelPortalQ875S4.
SMRQ875S4. Positions 3-501.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00109; UER00188.

Family and domain databases

Gene3D2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERPTHR11817. PTHR11817. 1 hit.
PfamPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSPR01050. PYRUVTKNASE.
SUPFAMSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsTIGR01064. pyruv_kin. 1 hit.
PROSITEPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPYK_LACK1
AccessionPrimary (citable) accession number: Q875S4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: June 1, 2003
Last modified: June 11, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways