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Q875S4

- KPYK_LACK1

UniProt

Q875S4 - KPYK_LACK1

Protein

Pyruvate kinase

Gene

PYK1

Organism
Lachancea kluyveri (strain ATCC 58438 / CBS 3082 / CCRC 21498 / NBRC 1685 / JCM 7257 / NCYC 543 / NRRL Y-12651) (Yeast) (Saccharomyces kluyveri)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + pyruvate = ADP + phosphoenolpyruvate.

    Cofactori

    Magnesium.By similarity
    Potassium.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei50 – 501SubstrateBy similarity
    Metal bindingi52 – 521PotassiumBy similarity
    Metal bindingi54 – 541PotassiumBy similarity
    Metal bindingi85 – 851PotassiumBy similarity
    Metal bindingi86 – 861Potassium; via carbonyl oxygenBy similarity
    Sitei241 – 2411Transition state stabilizerBy similarity
    Metal bindingi243 – 2431MagnesiumSequence Analysis
    Binding sitei266 – 2661Substrate; via amide nitrogenBy similarity
    Metal bindingi267 – 2671MagnesiumBy similarity
    Binding sitei267 – 2671Substrate; via amide nitrogenBy similarity
    Binding sitei299 – 2991SubstrateBy similarity
    Binding sitei338 – 3381ADPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. magnesium ion binding Source: InterPro
    3. potassium ion binding Source: InterPro
    4. pyruvate kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00188.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate kinase (EC:2.7.1.40)
    Short name:
    PK
    Gene namesi
    Name:PYK1
    Synonyms:CDC19
    OrganismiLachancea kluyveri (strain ATCC 58438 / CBS 3082 / CCRC 21498 / NBRC 1685 / JCM 7257 / NCYC 543 / NRRL Y-12651) (Yeast) (Saccharomyces kluyveri)
    Taxonomic identifieri226302 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeLachancea

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 501501Pyruvate kinasePRO_0000112117Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ875S4.
    SMRiQ875S4. Positions 3-501.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pyruvate kinase family.Curated

    Family and domain databases

    Gene3Di2.40.33.10. 1 hit.
    3.20.20.60. 2 hits.
    3.40.1380.20. 1 hit.
    InterProiIPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR011037. Pyrv_Knase-like_insert_dom.
    IPR015794. Pyrv_Knase_a/b.
    IPR018209. Pyrv_Knase_AS.
    IPR015793. Pyrv_Knase_brl.
    IPR015795. Pyrv_Knase_C.
    IPR015806. Pyrv_Knase_insert_dom.
    [Graphical view]
    PANTHERiPTHR11817. PTHR11817. 1 hit.
    PfamiPF00224. PK. 1 hit.
    PF02887. PK_C. 1 hit.
    [Graphical view]
    PRINTSiPR01050. PYRUVTKNASE.
    SUPFAMiSSF50800. SSF50800. 1 hit.
    SSF51621. SSF51621. 2 hits.
    SSF52935. SSF52935. 1 hit.
    TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
    PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q875S4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESRLGWLTE LQTETGANLR RTSIIGTIGP KTNNPETLVA LRKAGLNIVR    50
    MNFSHGSYEY HQSVIDNARK SEELYPGRPL AIALDTKGPE IRTGTTTNEV 100
    DYPIPPNHEM IFSIDDKYAK ACDDKVMYID YKNITKVIEK GKIIYVDDGV 150
    LSFEVLEVVD EQTLKVKSLN AGKICSHKGV NLPGTDVDLP ALSEKDKSDL 200
    RFGVKNGVHM VFASFIRTAQ DVLTIREVLG EDGKDVKIIV KIENQQGVNN 250
    FDEILKVTDG VMVARGDLGI EIPAPQVFAV QKKLIAKCNL AGKPVICATQ 300
    MLESMTYNPR PTRAEVSDVG NAVLDGADCV MLSGETAKGN YPINAVTIMA 350
    ETALIAEQAI PYVATYDDLR NFTPKPTSTT ETIAAAAVSS VFEQKAKAII 400
    VLSTTGDTPR LVSKYKPNVP IVMVTRNPRA ARFSHLYRGV FPFVYESDTE 450
    SEWTKDVESR LNFGIAKAKE FGMLKEGDTI VTIQGFAAGV GHSNTLRVLT 500
    V 501
    Length:501
    Mass (Da):54,895
    Last modified:June 1, 2003 - v1
    Checksum:i91291D046FB3174C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY144995 Genomic DNA. Translation: AAO32558.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY144995 Genomic DNA. Translation: AAO32558.1 .

    3D structure databases

    ProteinModelPortali Q875S4.
    SMRi Q875S4. Positions 3-501.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00188 .

    Family and domain databases

    Gene3Di 2.40.33.10. 1 hit.
    3.20.20.60. 2 hits.
    3.40.1380.20. 1 hit.
    InterProi IPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR011037. Pyrv_Knase-like_insert_dom.
    IPR015794. Pyrv_Knase_a/b.
    IPR018209. Pyrv_Knase_AS.
    IPR015793. Pyrv_Knase_brl.
    IPR015795. Pyrv_Knase_C.
    IPR015806. Pyrv_Knase_insert_dom.
    [Graphical view ]
    PANTHERi PTHR11817. PTHR11817. 1 hit.
    Pfami PF00224. PK. 1 hit.
    PF02887. PK_C. 1 hit.
    [Graphical view ]
    PRINTSi PR01050. PYRUVTKNASE.
    SUPFAMi SSF50800. SSF50800. 1 hit.
    SSF51621. SSF51621. 2 hits.
    SSF52935. SSF52935. 1 hit.
    TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
    PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Yeast genome duplication was followed by asynchronous differentiation of duplicated genes."
      Langkjaer R.B., Cliften P.F., Johnston M., Piskur J.
      Nature 421:848-852(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 58438 / CBS 3082 / CCRC 21498 / NBRC 1685 / JCM 7257 / NCYC 543 / NRRL Y-12651.

    Entry informationi

    Entry nameiKPYK_LACK1
    AccessioniPrimary (citable) accession number: Q875S4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3