Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q875M9 (KPYK_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pyruvate kinase

Short name=PK
EC=2.7.1.40
Gene names
Name:PYK1
Synonyms:CDC19
Ordered Locus Names:KLLA0F23397g
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces

Protein attributes

Sequence length501 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactor

Magnesium By similarity.

Potassium By similarity.

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the pyruvate kinase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 501501Pyruvate kinase
PRO_0000112114

Sites

Metal binding521Potassium By similarity
Metal binding541Potassium By similarity
Metal binding851Potassium By similarity
Metal binding861Potassium; via carbonyl oxygen By similarity
Metal binding2431Magnesium Potential
Metal binding2671Magnesium By similarity
Binding site501Substrate By similarity
Binding site2661Substrate; via amide nitrogen By similarity
Binding site2671Substrate; via amide nitrogen By similarity
Binding site2991Substrate By similarity
Binding site3381ADP Potential
Site2411Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q875M9 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 12F2D4C3E4940B95

FASTA50154,917
        10         20         30         40         50         60 
MESRLGWLTD LSTETGTNLR RTSIICTIGP KTNNPETLVE LRKAGMNIVR MNFSHGSYEY 

        70         80         90        100        110        120 
HQSVIDNARK SEELYQGRPL AIALDTKGPE IRTGTTTNDV DYPIPPNHEM IFTTDDKYAK 

       130        140        150        160        170        180 
ACDDKTMYVD YKNITKVIEA GRIIYVDDGV LSFEVLEVID DNTLKVKSLN AGKICSHKGV 

       190        200        210        220        230        240 
NLPGTDVDLP ALSEKDKSDL KFGVKNGVHM VFASFIRTAQ DVLTIREVLG EQGKDIKIIV 

       250        260        270        280        290        300 
KIENQQGVNN FDDILKVTDG VMVARGDLGI EIPAPQVFAV QKKLIAKCNL AGKPVICATQ 

       310        320        330        340        350        360 
MLESMTYNPR PTRAEVSDVG NAVLDGADCV MLSGETAKGN YPINAVKTMA ETALIAEQAI 

       370        380        390        400        410        420 
PYIPTYDDLR NLTPKPTSTT ETIAAASVSA VFEQKARALI VLSTTGDTPR LVAKYKPNVP 

       430        440        450        460        470        480 
IVMVTRNPRA ARFSHLYRGV FPFVYDESSD SEWTVDVEKR INFGVKKAKE FGILVDGDTI 

       490        500 
VTIQGFAAGV GNSNTLRVLT V 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY145040 Genomic DNA. Translation: AAO32602.1.
CR382126 Genomic DNA. Translation: CAG98830.1.
RefSeqXP_456122.1. XM_456122.1.

3D structure databases

ProteinModelPortalQ875M9.
SMRQ875M9. Positions 3-501.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ875M9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2895322.
KEGGkla:KLLA0F23397g.

Phylogenomic databases

eggNOGCOG0469.
HOGENOMHOG000021559.
KOK00873.
OMAHGTRIAN.
OrthoDBEOG7M6DJC.

Enzyme and pathway databases

UniPathwayUPA00109; UER00188.

Family and domain databases

Gene3D2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERPTHR11817. PTHR11817. 1 hit.
PfamPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSPR01050. PYRUVTKNASE.
SUPFAMSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsTIGR01064. pyruv_kin. 1 hit.
PROSITEPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPYK_KLULA
AccessionPrimary (citable) accession number: Q875M9
Secondary accession number(s): Q6CIW7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: June 1, 2003
Last modified: November 13, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways