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Q875M9

- KPYK_KLULA

UniProt

Q875M9 - KPYK_KLULA

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Protein

Pyruvate kinase

Gene

PYK1

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactori

Protein has several cofactor binding sites:

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei50 – 501SubstrateBy similarity
Metal bindingi52 – 521PotassiumBy similarity
Metal bindingi54 – 541PotassiumBy similarity
Metal bindingi85 – 851PotassiumBy similarity
Metal bindingi86 – 861Potassium; via carbonyl oxygenBy similarity
Sitei241 – 2411Transition state stabilizerBy similarity
Metal bindingi243 – 2431MagnesiumSequence Analysis
Binding sitei266 – 2661Substrate; via amide nitrogenBy similarity
Metal bindingi267 – 2671MagnesiumBy similarity
Binding sitei267 – 2671Substrate; via amide nitrogenBy similarity
Binding sitei299 – 2991SubstrateBy similarity
Binding sitei338 – 3381ADPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: InterPro
  3. potassium ion binding Source: InterPro
  4. pyruvate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinase (EC:2.7.1.40)
Short name:
PK
Gene namesi
Name:PYK1
Synonyms:CDC19
Ordered Locus Names:KLLA0F23397g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598: Chromosome F

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Pyruvate kinasePRO_0000112114Add
BLAST

Proteomic databases

PRIDEiQ875M9.

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ875M9.
SMRiQ875M9. Positions 3-501.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.Curated

Phylogenomic databases

eggNOGiCOG0469.
HOGENOMiHOG000021559.
InParanoidiQ875M9.
KOiK00873.
OMAiGTHEEHK.
OrthoDBiEOG7M6DJC.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q875M9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESRLGWLTD LSTETGTNLR RTSIICTIGP KTNNPETLVE LRKAGMNIVR
60 70 80 90 100
MNFSHGSYEY HQSVIDNARK SEELYQGRPL AIALDTKGPE IRTGTTTNDV
110 120 130 140 150
DYPIPPNHEM IFTTDDKYAK ACDDKTMYVD YKNITKVIEA GRIIYVDDGV
160 170 180 190 200
LSFEVLEVID DNTLKVKSLN AGKICSHKGV NLPGTDVDLP ALSEKDKSDL
210 220 230 240 250
KFGVKNGVHM VFASFIRTAQ DVLTIREVLG EQGKDIKIIV KIENQQGVNN
260 270 280 290 300
FDDILKVTDG VMVARGDLGI EIPAPQVFAV QKKLIAKCNL AGKPVICATQ
310 320 330 340 350
MLESMTYNPR PTRAEVSDVG NAVLDGADCV MLSGETAKGN YPINAVKTMA
360 370 380 390 400
ETALIAEQAI PYIPTYDDLR NLTPKPTSTT ETIAAASVSA VFEQKARALI
410 420 430 440 450
VLSTTGDTPR LVAKYKPNVP IVMVTRNPRA ARFSHLYRGV FPFVYDESSD
460 470 480 490 500
SEWTVDVEKR INFGVKKAKE FGILVDGDTI VTIQGFAAGV GNSNTLRVLT

V
Length:501
Mass (Da):54,917
Last modified:June 1, 2003 - v1
Checksum:i12F2D4C3E4940B95
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY145040 Genomic DNA. Translation: AAO32602.1.
CR382126 Genomic DNA. Translation: CAG98830.1.
RefSeqiXP_456122.1. XM_456122.1.

Genome annotation databases

GeneIDi2895322.
KEGGikla:KLLA0F23397g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY145040 Genomic DNA. Translation: AAO32602.1 .
CR382126 Genomic DNA. Translation: CAG98830.1 .
RefSeqi XP_456122.1. XM_456122.1.

3D structure databases

ProteinModelPortali Q875M9.
SMRi Q875M9. Positions 3-501.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q875M9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2895322.
KEGGi kla:KLLA0F23397g.

Phylogenomic databases

eggNOGi COG0469.
HOGENOMi HOG000021559.
InParanoidi Q875M9.
KOi K00873.
OMAi GTHEEHK.
OrthoDBi EOG7M6DJC.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00188 .

Family and domain databases

Gene3Di 2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProi IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view ]
PANTHERi PTHR11817. PTHR11817. 1 hit.
Pfami PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view ]
PRINTSi PR01050. PYRUVTKNASE.
SUPFAMi SSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Yeast genome duplication was followed by asynchronous differentiation of duplicated genes."
    Langkjaer R.B., Cliften P.F., Johnston M., Piskur J.
    Nature 421:848-852(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 76492 / CBS 2359/152 / CLIB 210.
  2. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.

Entry informationi

Entry nameiKPYK_KLULA
AccessioniPrimary (citable) accession number: Q875M9
Secondary accession number(s): Q6CIW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: June 1, 2003
Last modified: November 26, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3