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Q875M9

- KPYK_KLULA

UniProt

Q875M9 - KPYK_KLULA

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Protein

Pyruvate kinase

Gene
PYK1, CDC19, KLLA0F23397g
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactori

Magnesium By similarity.
Potassium By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei50 – 501Substrate By similarity
Metal bindingi52 – 521Potassium By similarity
Metal bindingi54 – 541Potassium By similarity
Metal bindingi85 – 851Potassium By similarity
Metal bindingi86 – 861Potassium; via carbonyl oxygen By similarity
Sitei241 – 2411Transition state stabilizer By similarity
Metal bindingi243 – 2431Magnesium Reviewed prediction
Binding sitei266 – 2661Substrate; via amide nitrogen By similarity
Metal bindingi267 – 2671Magnesium By similarity
Binding sitei267 – 2671Substrate; via amide nitrogen By similarity
Binding sitei299 – 2991Substrate By similarity
Binding sitei338 – 3381ADP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: InterPro
  3. potassium ion binding Source: InterPro
  4. pyruvate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinase (EC:2.7.1.40)
Short name:
PK
Gene namesi
Name:PYK1
Synonyms:CDC19
Ordered Locus Names:KLLA0F23397g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598: Chromosome F

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Pyruvate kinasePRO_0000112114Add
BLAST

Proteomic databases

PRIDEiQ875M9.

Interactioni

Subunit structurei

Homotetramer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ875M9.
SMRiQ875M9. Positions 3-501.

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.

Phylogenomic databases

eggNOGiCOG0469.
HOGENOMiHOG000021559.
KOiK00873.
OMAiGTHEEHK.
OrthoDBiEOG7M6DJC.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q875M9-1 [UniParc]FASTAAdd to Basket

« Hide

MESRLGWLTD LSTETGTNLR RTSIICTIGP KTNNPETLVE LRKAGMNIVR    50
MNFSHGSYEY HQSVIDNARK SEELYQGRPL AIALDTKGPE IRTGTTTNDV 100
DYPIPPNHEM IFTTDDKYAK ACDDKTMYVD YKNITKVIEA GRIIYVDDGV 150
LSFEVLEVID DNTLKVKSLN AGKICSHKGV NLPGTDVDLP ALSEKDKSDL 200
KFGVKNGVHM VFASFIRTAQ DVLTIREVLG EQGKDIKIIV KIENQQGVNN 250
FDDILKVTDG VMVARGDLGI EIPAPQVFAV QKKLIAKCNL AGKPVICATQ 300
MLESMTYNPR PTRAEVSDVG NAVLDGADCV MLSGETAKGN YPINAVKTMA 350
ETALIAEQAI PYIPTYDDLR NLTPKPTSTT ETIAAASVSA VFEQKARALI 400
VLSTTGDTPR LVAKYKPNVP IVMVTRNPRA ARFSHLYRGV FPFVYDESSD 450
SEWTVDVEKR INFGVKKAKE FGILVDGDTI VTIQGFAAGV GNSNTLRVLT 500
V 501
Length:501
Mass (Da):54,917
Last modified:June 1, 2003 - v1
Checksum:i12F2D4C3E4940B95
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY145040 Genomic DNA. Translation: AAO32602.1.
CR382126 Genomic DNA. Translation: CAG98830.1.
RefSeqiXP_456122.1. XM_456122.1.

Genome annotation databases

GeneIDi2895322.
KEGGikla:KLLA0F23397g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY145040 Genomic DNA. Translation: AAO32602.1 .
CR382126 Genomic DNA. Translation: CAG98830.1 .
RefSeqi XP_456122.1. XM_456122.1.

3D structure databases

ProteinModelPortali Q875M9.
SMRi Q875M9. Positions 3-501.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q875M9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2895322.
KEGGi kla:KLLA0F23397g.

Phylogenomic databases

eggNOGi COG0469.
HOGENOMi HOG000021559.
KOi K00873.
OMAi GTHEEHK.
OrthoDBi EOG7M6DJC.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00188 .

Family and domain databases

Gene3Di 2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProi IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view ]
PANTHERi PTHR11817. PTHR11817. 1 hit.
Pfami PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view ]
PRINTSi PR01050. PYRUVTKNASE.
SUPFAMi SSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Yeast genome duplication was followed by asynchronous differentiation of duplicated genes."
    Langkjaer R.B., Cliften P.F., Johnston M., Piskur J.
    Nature 421:848-852(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 76492 / CBS 2359/152 / CLIB 210.
  2. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.

Entry informationi

Entry nameiKPYK_KLULA
AccessioniPrimary (citable) accession number: Q875M9
Secondary accession number(s): Q6CIW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: June 1, 2003
Last modified: June 11, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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