Reviewed,
UniProtKB/Swiss-Prot Q875K1 (ERG6_CLALS)
Last modified
January 20, 2009.
Version 28.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Sterol 24-C-methyltransferase EC=2.1.1.41 Alternative name(s): Delta(24)-sterol C-methyltransferase | ||
| Gene names |
| ||
| Organism | Clavispora lusitaniae (Candida lusitaniae) | ||
| Taxonomic identifier | 36911 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Metschnikowiaceae › Clavispora |
Protein attributes
| Sequence length | 375 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol By similarity. |
| Catalytic activity | S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol. |
| Pathway | Steroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 1/5. |
| Sequence similarities | Belongs to the methyltransferase superfamily. ERG6 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Lipid synthesis Steroid biosynthesis Sterol biosynthesis |
| Ligand | S-adenosyl-L-methionine |
| Molecular function | Methyltransferase Transferase |
| Gene Ontology (GO) | |
| Biological process | sterol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | sterol 24-C-methyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 375 | 375 | Sterol 24-C-methyltransferase | PRO_0000124791 | |||
Sequences
| ||||||||||||||||||
References
| [1] | "Disruption of ergosterol biosynthesis confers resistance to amphotericin B in Candida lusitaniae." Young L.Y., Hull C.M., Heitman J. Antimicrob. Agents Chemother. 47:2717-2724(2003) [PubMed: 12936965] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 42720. |
Cross-references
Sequence databases | |
|---|---|
| AY179503 Genomic DNA. Translation: AAO21936.1. | |
3D structure databases | |
| ModBase | Search... |
Enzyme and pathway databases | |
| BRENDA | 2.1.1.41. 274765. |
Family and domain databases | |
| InterPro | IPR013216. Methyltransf_11. IPR013705. Sterol_MeTrfase_C. [Graphical view] |
| Pfam | PF08241. Methyltransf_11. 1 hit. PF08498. Sterol_MT_C. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ERG6_CLALS | ||||||||
| Accession | Primary (citable) accession number: Q875K1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


