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Q875K1 (ERG6_CLAL4) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Sterol 24-C-methyltransferase

EC=2.1.1.41
Alternative name(s):
Delta(24)-sterol C-methyltransferase
Gene names
Name:ERG6
ORF Names:CLUG_02673
OrganismClavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae) [Complete proteome]
Taxonomic identifier306902 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesMetschnikowiaceaeClavispora

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol By similarity.

Catalytic activity

S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.

Pathway

Steroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 1/5.

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 375375Sterol 24-C-methyltransferase
PRO_0000124791

Sequences

Sequence LengthMass (Da)Tools
Q875K1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 4B652EAA78F7FBD7

FASTA37542,698
        10         20         30         40         50         60 
MTSVKLAEKN FEQDKEFAKA MHGDSYKKRG ISALMAKAKE ASDVATNGYF KHWDGGVSED 

        70         80         90        100        110        120 
DEKKRLDDYS SLTKNYYNLV TDFYEYGWGS SFHFSRYYKG EAFRQATARH EHFLAHKMNI 

       130        140        150        160        170        180 
NENMRVLDVG CGVGGPGREI CRFTDCTIVG LNNNDYQVER AQYYAKKYKL DDKLSYVKGD 

       190        200        210        220        230        240 
FMQMDFEPES FDAVYAIEAT VHAPVLEGVY SEIYKVLKPG GVFGVYEWVM TDKYDENNEE 

       250        260        270        280        290        300 
HRKIAYGIEV GDGIPKMYKR EVAEQALKNV GFDIEYEKDL ADVNDEIPWY YPLAGEWKYV 

       310        320        330        340        350        360 
QTLSDCFTIF RTSKIGRTVT TNVVGLMEKI GLAPKGSKQV TGALEDAAVN LVAGGEQKLF 

       370 
TPMMLYIARK PLDAK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY179503 Genomic DNA. Translation: AAO21936.1.
CH408078 Genomic DNA. Translation: EEQ38547.1.
RefSeqXP_002617229.1. XM_002617183.1.

3D structure databases

ProteinModelPortalQ875K1.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8497819.
KEGGclu:CLUG_02673.

Phylogenomic databases

KOK00559.
OrthoDBEOG7DVDMW.

Enzyme and pathway databases

UniPathwayUPA00768; UER00760.

Family and domain databases

InterProIPR025810. ERG6.
IPR013216. Methyltransf_11.
IPR013705. Sterol_MeTrfase_C.
[Graphical view]
PfamPF08241. Methyltransf_11. 1 hit.
PF08498. Sterol_MT_C. 1 hit.
[Graphical view]
PROSITEPS51685. SAM_MT_ERG6_SMT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameERG6_CLAL4
AccessionPrimary (citable) accession number: Q875K1
Secondary accession number(s): C4Y2B0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2003
Last modified: November 13, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways