Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q875K1

- ERG6_CLAL4

UniProt

Q875K1 - ERG6_CLAL4

Protein

Sterol 24-C-methyltransferase

Gene

ERG6

Organism
Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.

    Pathwayi

    GO - Molecular functioni

    1. sterol 24-C-methyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. sterol biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    UniPathwayiUPA00768; UER00760.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sterol 24-C-methyltransferase (EC:2.1.1.41)
    Alternative name(s):
    Delta(24)-sterol C-methyltransferase
    Gene namesi
    Name:ERG6
    ORF Names:CLUG_02673
    OrganismiClavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)
    Taxonomic identifieri306902 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesMetschnikowiaceaeClavispora
    ProteomesiUP000007703: Unassembled WGS sequence

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 375375Sterol 24-C-methyltransferasePRO_0000124791Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ875K1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.PROSITE-ProRule annotation

    Phylogenomic databases

    KOiK00559.
    OrthoDBiEOG7DVDMW.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR025810. ERG6.
    IPR013216. Methyltransf_11.
    IPR029063. SAM-dependent_MTases-like.
    IPR013705. Sterol_MeTrfase_C.
    [Graphical view]
    PfamiPF08241. Methyltransf_11. 1 hit.
    PF08498. Sterol_MT_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 2 hits.
    PROSITEiPS51685. SAM_MT_ERG6_SMT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q875K1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSVKLAEKN FEQDKEFAKA MHGDSYKKRG ISALMAKAKE ASDVATNGYF    50
    KHWDGGVSED DEKKRLDDYS SLTKNYYNLV TDFYEYGWGS SFHFSRYYKG 100
    EAFRQATARH EHFLAHKMNI NENMRVLDVG CGVGGPGREI CRFTDCTIVG 150
    LNNNDYQVER AQYYAKKYKL DDKLSYVKGD FMQMDFEPES FDAVYAIEAT 200
    VHAPVLEGVY SEIYKVLKPG GVFGVYEWVM TDKYDENNEE HRKIAYGIEV 250
    GDGIPKMYKR EVAEQALKNV GFDIEYEKDL ADVNDEIPWY YPLAGEWKYV 300
    QTLSDCFTIF RTSKIGRTVT TNVVGLMEKI GLAPKGSKQV TGALEDAAVN 350
    LVAGGEQKLF TPMMLYIARK PLDAK 375
    Length:375
    Mass (Da):42,698
    Last modified:June 1, 2003 - v1
    Checksum:i4B652EAA78F7FBD7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY179503 Genomic DNA. Translation: AAO21936.1.
    CH408078 Genomic DNA. Translation: EEQ38547.1.
    RefSeqiXP_002617229.1. XM_002617183.1.

    Genome annotation databases

    GeneIDi8497819.
    KEGGiclu:CLUG_02673.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY179503 Genomic DNA. Translation: AAO21936.1 .
    CH408078 Genomic DNA. Translation: EEQ38547.1 .
    RefSeqi XP_002617229.1. XM_002617183.1.

    3D structure databases

    ProteinModelPortali Q875K1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8497819.
    KEGGi clu:CLUG_02673.

    Phylogenomic databases

    KOi K00559.
    OrthoDBi EOG7DVDMW.

    Enzyme and pathway databases

    UniPathwayi UPA00768 ; UER00760 .

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR025810. ERG6.
    IPR013216. Methyltransf_11.
    IPR029063. SAM-dependent_MTases-like.
    IPR013705. Sterol_MeTrfase_C.
    [Graphical view ]
    Pfami PF08241. Methyltransf_11. 1 hit.
    PF08498. Sterol_MT_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 2 hits.
    PROSITEi PS51685. SAM_MT_ERG6_SMT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Disruption of ergosterol biosynthesis confers resistance to amphotericin B in Candida lusitaniae."
      Young L.Y., Hull C.M., Heitman J.
      Antimicrob. Agents Chemother. 47:2717-2724(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 42720.

    Entry informationi

    Entry nameiERG6_CLAL4
    AccessioniPrimary (citable) accession number: Q875K1
    Secondary accession number(s): C4Y2B0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3