Reviewed, UniProtKB/Swiss-Prot Q875K1 (ERG6_CLAL4)

Names and origin

Protein names

Recommended name:
    Sterol 24-C-methyltransferase
    EC=2.1.1.41
Alternative name(s):
    Delta(24)-sterol C-methyltransferase

Gene names

Name:	ERG6
ORF Names:	CLUG_02673

Organism

Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)

Taxonomic identifier

306902 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Metschnikowiaceae › Clavispora

Protein attributes

Sequence length	375 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol By similarity.
Catalytic activity	S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.
Pathway	Steroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 1/5.
Sequence similarities	Belongs to the methyltransferase superfamily. ERG6 family.

Ontologies

Keywords
Biological process	Lipid synthesis Steroid biosynthesis Sterol biosynthesis
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Gene Ontology (GO)
Biological process	sterol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	sterol 24-C-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 375	375	Sterol 24-C-methyltransferase		PRO_0000124791

Sequences

	Sequence		Length	Mass (Da)
	Q875K1-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 4B652EAA78F7FBD7	FASTA	375	42,698
	10 20 30 40 50 60 MTSVKLAEKN FEQDKEFAKA MHGDSYKKRG ISALMAKAKE ASDVATNGYF KHWDGGVSED 70 80 90 100 110 120 DEKKRLDDYS SLTKNYYNLV TDFYEYGWGS SFHFSRYYKG EAFRQATARH EHFLAHKMNI 130 140 150 160 170 180 NENMRVLDVG CGVGGPGREI CRFTDCTIVG LNNNDYQVER AQYYAKKYKL DDKLSYVKGD 190 200 210 220 230 240 FMQMDFEPES FDAVYAIEAT VHAPVLEGVY SEIYKVLKPG GVFGVYEWVM TDKYDENNEE 250 260 270 280 290 300 HRKIAYGIEV GDGIPKMYKR EVAEQALKNV GFDIEYEKDL ADVNDEIPWY YPLAGEWKYV 310 320 330 340 350 360 QTLSDCFTIF RTSKIGRTVT TNVVGLMEKI GLAPKGSKQV TGALEDAAVN LVAGGEQKLF 370 TPMMLYIARK PLDAK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Disruption of ergosterol biosynthesis confers resistance to amphotericin B in Candida lusitaniae." Young L.Y., Hull C.M., Heitman J. Antimicrob. Agents Chemother. 47:2717-2724(2003) [PubMed: 12936965] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Evolution of pathogenicity and sexual reproduction in eight Candida genomes." Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S., Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I., Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C., Fitzpatrick D.A., de Groot P.W.J. , Harris D., Hoyer L.L., Hube B., Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D., Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T., Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C., Birren B.W., Kellis M., Cuomo C.A. Nature 459:657-662(2009) [PubMed: 19465905] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY179503 Genomic DNA. Translation: AAO21936.1. CH408078 Genomic DNA. Translation: EEQ38547.1.
RefSeq	XP_002617229.1.
3D structure databases
SMR	Q875K1. Positions 43-226, 72-282.
ModBase	Search...
Genome annotation databases
GeneID	8497819.
Phylogenomic databases
PhylomeDB	Q875K1.
Enzyme and pathway databases
BRENDA	2.1.1.41. 274765.
Family and domain databases
InterPro	IPR013216. Methyltransf_11. IPR013705. Sterol_MeTrfase_C. [Graphical view]
Pfam	PF08241. Methyltransf_11. 1 hit. PF08498. Sterol_MT_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ERG6_CLAL4

Accession

Primary (citable) accession number: Q875K1
Secondary accession number(s): C4Y2B0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	June 1, 2003
Last modified:	January 19, 2010
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)