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Q875K1

- ERG6_CLAL4

UniProt

Q875K1 - ERG6_CLAL4

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Protein

Sterol 24-C-methyltransferase

Gene

ERG6

Organism
Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.By similarity

Catalytic activityi

S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.

Pathwayi

GO - Molecular functioni

  1. sterol 24-C-methyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. sterol biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00768; UER00760.

Names & Taxonomyi

Protein namesi
Recommended name:
Sterol 24-C-methyltransferase (EC:2.1.1.41)
Alternative name(s):
Delta(24)-sterol C-methyltransferase
Gene namesi
Name:ERG6
ORF Names:CLUG_02673
OrganismiClavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)
Taxonomic identifieri306902 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesMetschnikowiaceaeClavispora
ProteomesiUP000007703: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Sterol 24-C-methyltransferasePRO_0000124791Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ875K1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiQ875K1.
KOiK00559.
OrthoDBiEOG7DVDMW.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025810. ERG6.
IPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases-like.
IPR013705. Sterol_MeTrfase_C.
[Graphical view]
PfamiPF08241. Methyltransf_11. 1 hit.
PF08498. Sterol_MT_C. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51685. SAM_MT_ERG6_SMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q875K1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSVKLAEKN FEQDKEFAKA MHGDSYKKRG ISALMAKAKE ASDVATNGYF
60 70 80 90 100
KHWDGGVSED DEKKRLDDYS SLTKNYYNLV TDFYEYGWGS SFHFSRYYKG
110 120 130 140 150
EAFRQATARH EHFLAHKMNI NENMRVLDVG CGVGGPGREI CRFTDCTIVG
160 170 180 190 200
LNNNDYQVER AQYYAKKYKL DDKLSYVKGD FMQMDFEPES FDAVYAIEAT
210 220 230 240 250
VHAPVLEGVY SEIYKVLKPG GVFGVYEWVM TDKYDENNEE HRKIAYGIEV
260 270 280 290 300
GDGIPKMYKR EVAEQALKNV GFDIEYEKDL ADVNDEIPWY YPLAGEWKYV
310 320 330 340 350
QTLSDCFTIF RTSKIGRTVT TNVVGLMEKI GLAPKGSKQV TGALEDAAVN
360 370
LVAGGEQKLF TPMMLYIARK PLDAK
Length:375
Mass (Da):42,698
Last modified:June 1, 2003 - v1
Checksum:i4B652EAA78F7FBD7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY179503 Genomic DNA. Translation: AAO21936.1.
CH408078 Genomic DNA. Translation: EEQ38547.1.
RefSeqiXP_002617229.1. XM_002617183.1.

Genome annotation databases

GeneIDi8497819.
KEGGiclu:CLUG_02673.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY179503 Genomic DNA. Translation: AAO21936.1 .
CH408078 Genomic DNA. Translation: EEQ38547.1 .
RefSeqi XP_002617229.1. XM_002617183.1.

3D structure databases

ProteinModelPortali Q875K1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 8497819.
KEGGi clu:CLUG_02673.

Phylogenomic databases

InParanoidi Q875K1.
KOi K00559.
OrthoDBi EOG7DVDMW.

Enzyme and pathway databases

UniPathwayi UPA00768 ; UER00760 .

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR025810. ERG6.
IPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases-like.
IPR013705. Sterol_MeTrfase_C.
[Graphical view ]
Pfami PF08241. Methyltransf_11. 1 hit.
PF08498. Sterol_MT_C. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 2 hits.
PROSITEi PS51685. SAM_MT_ERG6_SMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Disruption of ergosterol biosynthesis confers resistance to amphotericin B in Candida lusitaniae."
    Young L.Y., Hull C.M., Heitman J.
    Antimicrob. Agents Chemother. 47:2717-2724(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 42720.

Entry informationi

Entry nameiERG6_CLAL4
AccessioniPrimary (citable) accession number: Q875K1
Secondary accession number(s): C4Y2B0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3