Reviewed,
UniProtKB/Swiss-Prot Q875K1 (ERG6_CLAL4)
Last modified
January 19, 2010.
Version 31.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Sterol 24-C-methyltransferase EC=2.1.1.41 Alternative name(s): Delta(24)-sterol C-methyltransferase | ||||
| Gene names |
| ||||
| Organism | Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae) | ||||
| Taxonomic identifier | 306902 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Metschnikowiaceae › Clavispora |
Protein attributes
| Sequence length | 375 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol By similarity. |
| Catalytic activity | S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol. |
| Pathway | Steroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 1/5. |
| Sequence similarities | Belongs to the methyltransferase superfamily. ERG6 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Lipid synthesis Steroid biosynthesis Sterol biosynthesis |
| Ligand | S-adenosyl-L-methionine |
| Molecular function | Methyltransferase Transferase |
| Gene Ontology (GO) | |
| Biological process | sterol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | sterol 24-C-methyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 375 | 375 | Sterol 24-C-methyltransferase | PRO_0000124791 | |||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Disruption of ergosterol biosynthesis confers resistance to amphotericin B in Candida lusitaniae." Young L.Y., Hull C.M., Heitman J. Antimicrob. Agents Chemother. 47:2717-2724(2003) [PubMed: 12936965] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Evolution of pathogenicity and sexual reproduction in eight Candida genomes." Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S., Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I., Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C., Fitzpatrick D.A., de Groot P.W.J. Cuomo C.A.Nature 459:657-662(2009) [PubMed: 19465905] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AY179503 Genomic DNA. Translation: AAO21936.1. CH408078 Genomic DNA. Translation: EEQ38547.1. |
| RefSeq | XP_002617229.1. |
3D structure databases | |
| SMR | Q875K1. Positions 43-226, 72-282. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 8497819. |
Phylogenomic databases | |
| PhylomeDB | Q875K1. |
Enzyme and pathway databases | |
| BRENDA | 2.1.1.41. 274765. |
Family and domain databases | |
| InterPro | IPR013216. Methyltransf_11. IPR013705. Sterol_MeTrfase_C. [Graphical view] |
| Pfam | PF08241. Methyltransf_11. 1 hit. PF08498. Sterol_MT_C. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ERG6_CLAL4 | ||||||||
| Accession | Primary (citable) accession number: Q875K1 Secondary accession number(s): C4Y2B0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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