Q875I3 (TRPF_HANAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase
Short name=PRAI
EC=5.3.1.24

Gene names

Name:

TRP1

Organism

Hansenula anomala (Yeast) (Candida pelliculosa)

Taxonomic identifier

4927 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Phaffomycetaceae › Wickerhamomyces

Protein attributes

Sequence length	232 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.
Sequence similarities	Belongs to the TrpF family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Isomerase
Gene Ontology (GO)
Biological_process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	phosphoribosylanthranilate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 232	232	N-(5'-phosphoribosyl)anthranilate isomerase		PRO_0000154332

Sequences

	Sequence		Length	Mass (Da)
	Q875I3 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 122926A9FC253680	FASTA	232	25,553
	10 20 30 40 50 60 MLVKICGVKD VEAAQVALES GADMIGMIFV PGKPRTIQVS NAKEVVSLVE SKRKGLNSNE 70 80 90 100 110 120 LYDSLKPGQD SLWFEQVHDS IKSNGPYSVG VFRNQSIEEI NNIIEEVDID FVQLHGQESH 130 140 150 160 170 180 DEYIPQLKKP VITRFVPNET KVLQSLKPNK HLLPLFDSEA GGEGVKLNWS NLSDWSAKNN 190 200 210 220 230 ARYLLAGGLT PDNVHEAIKL DGVIGVDVSG GVETNGVKDY VKIKEFVKNA LQ

References

[1]	"Cloning and sequence analysis of the TRP1 gene encoding the phosphoribosyl anthranilate isomerase from Pichia anomala (strain K)." Friel D., Vandenbol M., Jijakli M.H. Yeast 20:1331-1337(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY198188 Genomic DNA. Translation: AAO19636.1.
3D structure databases
ProteinModelPortal	Q875I3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
UniPathway	UPA00035; UER00042.
Family and domain databases
Gene3D	3.20.20.70. 2 hits.
InterPro	IPR013785. Aldolase_TIM. IPR001240. PRAI. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Pfam	PF00697. PRAI. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPF_HANAN

Accession

Primary (citable) accession number: Q875I3

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	June 1, 2003
Last modified:	March 6, 2013
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program