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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

TRP1

Organism
Hansenula anomala (Yeast) (Candida pelliculosa)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.

Pathwayi

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042.

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:TRP1
OrganismiHansenula anomala (Yeast) (Candida pelliculosa)
Taxonomic identifieri4927 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPhaffomycetaceaeWickerhamomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 232232N-(5'-phosphoribosyl)anthranilate isomerasePRO_0000154332Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ875I3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.Curated

Family and domain databases

Gene3Di3.20.20.70. 2 hits.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 2 hits.

Sequencei

Sequence statusi: Complete.

Q875I3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVKICGVKD VEAAQVALES GADMIGMIFV PGKPRTIQVS NAKEVVSLVE
60 70 80 90 100
SKRKGLNSNE LYDSLKPGQD SLWFEQVHDS IKSNGPYSVG VFRNQSIEEI
110 120 130 140 150
NNIIEEVDID FVQLHGQESH DEYIPQLKKP VITRFVPNET KVLQSLKPNK
160 170 180 190 200
HLLPLFDSEA GGEGVKLNWS NLSDWSAKNN ARYLLAGGLT PDNVHEAIKL
210 220 230
DGVIGVDVSG GVETNGVKDY VKIKEFVKNA LQ
Length:232
Mass (Da):25,553
Last modified:June 1, 2003 - v1
Checksum:i122926A9FC253680
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY198188 Genomic DNA. Translation: AAO19636.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY198188 Genomic DNA. Translation: AAO19636.1.

3D structure databases

ProteinModelPortaliQ875I3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042.

Family and domain databases

Gene3Di3.20.20.70. 2 hits.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Cloning and sequence analysis of the TRP1 gene encoding the phosphoribosyl anthranilate isomerase from Pichia anomala (strain K)."
    Friel D., Vandenbol M., Jijakli M.H.
    Yeast 20:1331-1337(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K.

Entry informationi

Entry nameiTRPF_HANAN
AccessioniPrimary (citable) accession number: Q875I3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2003
Last modified: April 1, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.