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Protein

Glutamine synthetase

Gene

GLN1

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase (EC:6.3.1.2)
Short name:
GS
Alternative name(s):
Glutamate--ammonia ligase
Gene namesi
Name:GLN1
Ordered Locus Names:KLLA0E06259g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome E

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001531601 – 372Glutamine synthetaseAdd BLAST372

Interactioni

Subunit structurei

Homooctamer.By similarity

Protein-protein interaction databases

STRINGi284590.XP_454231.1.

Structurei

3D structure databases

ProteinModelPortaliQ874T6.
SMRiQ874T6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Phylogenomic databases

eggNOGiKOG0683. Eukaryota.
COG0174. LUCA.
HOGENOMiHOG000061500.
InParanoidiQ874T6.
KOiK01915.
OMAiMMPDGVT.
OrthoDBiEOG092C2OM1.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiView protein in InterPro
IPR008147. Gln_synt_b-grasp.
IPR036651. Gln_synt_N.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR027302. Gln_synth_N_conserv_site.
PfamiView protein in Pfam
PF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
SMARTiView protein in SMART
SM01230. Gln-synt_C. 1 hit.
SUPFAMiSSF54368. SSF54368. 1 hit.
SSF55931. SSF55931. 1 hit.
PROSITEiView protein in PROSITE
PS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q874T6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATSDIVEK THILQKYLEL DQRGAIIAEY VWIDSEGGLR SKGRTLNKKV
60 70 80 90 100
TSVDSLPEWN FDGSSTGQAP GHDSDIYLKP VAFYPDPFRR GDNIVVLAEC
110 120 130 140 150
WNNDGTPNKF NHRHEAAKLF EAHKDAEMWF GLEQEYTLFD QYDQVYGWPK
160 170 180 190 200
GGFPAPQGPY YCGVGAGKVF ARDVIEAHYR ACLYAGVNIS GINAEVMPSQ
210 220 230 240 250
WEFQVGPCEG IAMADQLWIA RYFLHRVAEE FGVKVSLHPK PLKGDWNGAG
260 270 280 290 300
CHTNVSTKLM RAPGGMKYIE DAIEKLSKRH NEHIKLYGAD NEQRLTGRHE
310 320 330 340 350
TASMSTFSSG VANRGASIRI PRSVNKEGYG YFEDRRPASN IDPYLVTGIM
360 370
CETVCGAIEN ANMTKEYERE SL
Length:372
Mass (Da):41,677
Last modified:June 1, 2003 - v1
Checksum:i70023A50041D1E65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ547613 Genomic DNA. Translation: CAD67983.1.
CR382125 Genomic DNA. Translation: CAG99318.1.
RefSeqiXP_454231.1. XM_454231.1.

Genome annotation databases

EnsemblFungiiCAG99318; CAG99318; KLLA0_E06293g.
GeneIDi2894685.
KEGGikla:KLLA0E06293g.

Similar proteinsi

Entry informationi

Entry nameiGLNA_KLULA
AccessioniPrimary (citable) accession number: Q874T6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: October 25, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families