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Q874R1

- RHO4_SCHPO

UniProt

Q874R1 - RHO4_SCHPO

Protein

GTP-binding protein rho4

Gene

rho4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (16 Jan 2004)
      Previous versions | rss
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    Functioni

    Required for cell separation. Involved in the regulation of the septum degradation during cytokinesis and in the organization of F-actin patches and cytoplasmic microtubules.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi21 – 288GTPBy similarity
    Nucleotide bindingi70 – 745GTPBy similarity

    GO - Molecular functioni

    1. GTPase activity Source: PomBase
    2. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. cellular protein localization Source: PomBase
    2. fungal-type cell wall organization or biogenesis Source: PomBase
    3. GTP catabolic process Source: GOC
    4. microtubule cytoskeleton organization Source: PomBase
    5. primary cell septum disassembly Source: PomBase
    6. regulation of actin cytoskeleton organization Source: PomBase
    7. regulation of cell shape Source: PomBase
    8. regulation of mitotic barrier septum assembly Source: PomBase
    9. small GTPase mediated signal transduction Source: InterPro

    Keywords - Biological processi

    Cell cycle, Cell division

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP-binding protein rho4
    Gene namesi
    Name:rho4
    ORF Names:SPAC16A10.04
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC16A10.04.

    Subcellular locationi

    Membrane 2 Publications
    Note: Membrane-bound. Associates with the septum during mitosis.

    GO - Cellular componenti

    1. barrier septum Source: PomBase
    2. cell cortex Source: PomBase
    3. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi23 – 231G → V: Cell lysis during separation. 2 Publications
    Mutagenesisi28 – 281T → N: No cell lysis. 1 Publication
    Mutagenesisi74 – 741Q → L: Shrunken cells. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 200200GTP-binding protein rho4PRO_0000198943Add
    BLAST
    Propeptidei201 – 2033Removed in mature formBy similarityPRO_0000281273

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei200 – 2001Cysteine methyl esterBy similarity
    Lipidationi200 – 2001S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Proteomic databases

    MaxQBiQ874R1.

    Interactioni

    Protein-protein interaction databases

    BioGridi280552. 17 interactions.
    STRINGi4896.SPAC16A10.04-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ874R1.
    SMRiQ874R1. Positions 15-184.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi43 – 519Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rho family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000233974.
    KOiK07975.
    OMAiKESMRGR.
    OrthoDBiEOG7SN8QP.
    PhylomeDBiQ874R1.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003578. Small_GTPase_Rho.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00174. RHO. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51420. RHO. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q874R1-1 [UniParc]FASTAAdd to Basket

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    MSAFKKSGSK SETSKKLVVV GDGGCGKTCL LIVFSSGTFP ERYVPTVFEN    50
    YITDITYGPN SKVIELALWD TAGQEEYDRL RPLSYPNSNV ILLCFSIDCP 100
    ASLNNVTEKW YPEVQHFCPR TPIVLVGLKA DLRKDRNATE VLRTQGLTPV 150
    TYQQAQSVAL SMNAPYVECS AKENTGVNEV FQLAVGLTIK KSFSFSKKSC 200
    VIL 203
    Length:203
    Mass (Da):22,408
    Last modified:January 16, 2004 - v2
    Checksum:i69025B96208649F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAD86931.2.
    RefSeqiNP_001018257.1. NM_001019469.2.

    Genome annotation databases

    EnsemblFungiiSPAC16A10.04.1; SPAC16A10.04.1:pep; SPAC16A10.04.
    GeneIDi3361476.
    KEGGispo:SPAC16A10.04.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAD86931.2 .
    RefSeqi NP_001018257.1. NM_001019469.2.

    3D structure databases

    ProteinModelPortali Q874R1.
    SMRi Q874R1. Positions 15-184.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 280552. 17 interactions.
    STRINGi 4896.SPAC16A10.04-1.

    Proteomic databases

    MaxQBi Q874R1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC16A10.04.1 ; SPAC16A10.04.1:pep ; SPAC16A10.04 .
    GeneIDi 3361476.
    KEGGi spo:SPAC16A10.04.

    Organism-specific databases

    PomBasei SPAC16A10.04.

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000233974.
    KOi K07975.
    OMAi KESMRGR.
    OrthoDBi EOG7SN8QP.
    PhylomeDBi Q874R1.

    Miscellaneous databases

    NextBioi 20811519.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003578. Small_GTPase_Rho.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00174. RHO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51420. RHO. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel Rho GTPase involved in cytokinesis and cell wall integrity in the fission yeast Schizosaccharomyces pombe."
      Santos B., Gutierrez J., Calonge T.M., Perez P.
      Eukaryot. Cell 2:521-533(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF GLY-23 AND THR-28.
    2. "The small GTPase Rho4 is involved in controlling cell morphology and septation in fission yeast."
      Nakano K., Mutoh T., Arai R., Mabuchi I.
      Genes Cells 8:357-370(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF GLY-23 AND GLN-74.
    3. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiRHO4_SCHPO
    AccessioniPrimary (citable) accession number: Q874R1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: January 16, 2004
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3