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Q874R1 (RHO4_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP-binding protein rho4
Gene names
Name:rho4
ORF Names:SPAC16A10.04
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length203 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for cell separation. Involved in the regulation of the septum degradation during cytokinesis and in the organization of F-actin patches and cytoplasmic microtubules. Ref.1 Ref.2

Subcellular location

Membrane. Note: Membrane-bound. Associates with the septum during mitosis. Ref.1 Ref.2

Sequence similarities

Belongs to the small GTPase superfamily. Rho family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 200200GTP-binding protein rho4
PRO_0000198943
Propeptide201 – 2033Removed in mature form By similarity
PRO_0000281273

Regions

Nucleotide binding21 – 288GTP By similarity
Nucleotide binding70 – 745GTP By similarity
Motif43 – 519Effector region By similarity

Amino acid modifications

Modified residue2001Cysteine methyl ester By similarity
Lipidation2001S-geranylgeranyl cysteine By similarity

Experimental info

Mutagenesis231G → V: Cell lysis during separation. Ref.1 Ref.2
Mutagenesis281T → N: No cell lysis. Ref.1
Mutagenesis741Q → L: Shrunken cells. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q874R1 [UniParc].

Last modified January 16, 2004. Version 2.
Checksum: 69025B96208649F9

FASTA20322,408
        10         20         30         40         50         60 
MSAFKKSGSK SETSKKLVVV GDGGCGKTCL LIVFSSGTFP ERYVPTVFEN YITDITYGPN 

        70         80         90        100        110        120 
SKVIELALWD TAGQEEYDRL RPLSYPNSNV ILLCFSIDCP ASLNNVTEKW YPEVQHFCPR 

       130        140        150        160        170        180 
TPIVLVGLKA DLRKDRNATE VLRTQGLTPV TYQQAQSVAL SMNAPYVECS AKENTGVNEV 

       190        200 
FQLAVGLTIK KSFSFSKKSC VIL 

« Hide

References

« Hide 'large scale' references
[1]"Novel Rho GTPase involved in cytokinesis and cell wall integrity in the fission yeast Schizosaccharomyces pombe."
Santos B., Gutierrez J., Calonge T.M., Perez P.
Eukaryot. Cell 2:521-533(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF GLY-23 AND THR-28.
[2]"The small GTPase Rho4 is involved in controlling cell morphology and septation in fission yeast."
Nakano K., Mutoh T., Arai R., Mabuchi I.
Genes Cells 8:357-370(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF GLY-23 AND GLN-74.
[3]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329670 Genomic DNA. Translation: CAD86931.2.
RefSeqNP_001018257.1. NM_001019469.2.

3D structure databases

ProteinModelPortalQ874R1.
SMRQ874R1. Positions 15-184.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid280552. 17 interactions.
STRING4896.SPAC16A10.04-1.

Proteomic databases

MaxQBQ874R1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC16A10.04.1; SPAC16A10.04.1:pep; SPAC16A10.04.
GeneID3361476.
KEGGspo:SPAC16A10.04.

Organism-specific databases

PomBaseSPAC16A10.04.

Phylogenomic databases

eggNOGCOG1100.
HOGENOMHOG000233974.
KOK07975.
OMAKESMRGR.
OrthoDBEOG7SN8QP.
PhylomeDBQ874R1.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00174. RHO. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20811519.

Entry information

Entry nameRHO4_SCHPO
AccessionPrimary (citable) accession number: Q874R1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: May 14, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names