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Protein

GTP-binding protein rho4

Gene

rho4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for cell separation. Involved in the regulation of the septum degradation during cytokinesis and in the organization of F-actin patches and cytoplasmic microtubules.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi21 – 28GTPBy similarity8
Nucleotide bindingi70 – 74GTPBy similarity5

GO - Molecular functioni

  • GTPase activity Source: PomBase
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • cellular protein localization Source: PomBase
  • division septum assembly Source: PomBase
  • fungal-type cell wall organization or biogenesis Source: PomBase
  • positive regulation of cell separation after cytokinesis Source: PomBase
  • primary cell septum disassembly Source: PomBase
  • regulation of actin cytoskeleton organization Source: PomBase
  • regulation of cell shape Source: PomBase
  • regulation of division septum assembly Source: PomBase
  • small GTPase mediated signal transduction Source: InterPro

Keywordsi

Biological processCell cycle, Cell division
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-194840 Rho GTPase cycle
R-SPO-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein rho4
Gene namesi
Name:rho4
ORF Names:SPAC16A10.04
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC16A10.04
PomBaseiSPAC16A10.04 rho4

Subcellular locationi

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi23G → V: Cell lysis during separation. 2 Publications1
Mutagenesisi28T → N: No cell lysis. 1 Publication1
Mutagenesisi74Q → L: Shrunken cells. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001989431 – 200GTP-binding protein rho4Add BLAST200
PropeptideiPRO_0000281273201 – 203Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei200Cysteine methyl esterBy similarity1
Lipidationi200S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiQ874R1
PaxDbiQ874R1
PRIDEiQ874R1

Interactioni

Protein-protein interaction databases

BioGridi280552, 25 interactors
STRINGi4896.SPAC16A10.04.1

Structurei

3D structure databases

ProteinModelPortaliQ874R1
SMRiQ874R1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi43 – 51Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

HOGENOMiHOG000233974
InParanoidiQ874R1
OMAiYAENRFP
OrthoDBiEOG092C4TDG
PhylomeDBiQ874R1

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q874R1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAFKKSGSK SETSKKLVVV GDGGCGKTCL LIVFSSGTFP ERYVPTVFEN
60 70 80 90 100
YITDITYGPN SKVIELALWD TAGQEEYDRL RPLSYPNSNV ILLCFSIDCP
110 120 130 140 150
ASLNNVTEKW YPEVQHFCPR TPIVLVGLKA DLRKDRNATE VLRTQGLTPV
160 170 180 190 200
TYQQAQSVAL SMNAPYVECS AKENTGVNEV FQLAVGLTIK KSFSFSKKSC

VIL
Length:203
Mass (Da):22,408
Last modified:January 16, 2004 - v2
Checksum:i69025B96208649F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAD86931.2
RefSeqiNP_001018257.1, NM_001019469.2

Genome annotation databases

EnsemblFungiiSPAC16A10.04.1; SPAC16A10.04.1:pep; SPAC16A10.04
GeneIDi3361476
KEGGispo:SPAC16A10.04

Similar proteinsi

Entry informationi

Entry nameiRHO4_SCHPO
AccessioniPrimary (citable) accession number: Q874R1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: May 23, 2018
This is version 127 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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