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Q874R1

- RHO4_SCHPO

UniProt

Q874R1 - RHO4_SCHPO

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Protein

GTP-binding protein rho4

Gene

rho4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Required for cell separation. Involved in the regulation of the septum degradation during cytokinesis and in the organization of F-actin patches and cytoplasmic microtubules.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi21 – 288GTPBy similarity
Nucleotide bindingi70 – 745GTPBy similarity

GO - Molecular functioni

  1. GTPase activity Source: PomBase
  2. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. cellular protein localization Source: PomBase
  2. fungal-type cell wall organization or biogenesis Source: PomBase
  3. GTP catabolic process Source: GOC
  4. microtubule cytoskeleton organization Source: PomBase
  5. primary cell septum disassembly Source: PomBase
  6. regulation of actin cytoskeleton organization Source: PomBase
  7. regulation of cell shape Source: PomBase
  8. regulation of mitotic barrier septum assembly Source: PomBase
  9. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein rho4
Gene namesi
Name:rho4
ORF Names:SPAC16A10.04
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC16A10.04.

Subcellular locationi

Membrane 2 Publications
Note: Membrane-bound. Associates with the septum during mitosis.

GO - Cellular componenti

  1. barrier septum Source: PomBase
  2. cell cortex Source: PomBase
  3. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi23 – 231G → V: Cell lysis during separation. 2 Publications
Mutagenesisi28 – 281T → N: No cell lysis. 1 Publication
Mutagenesisi74 – 741Q → L: Shrunken cells. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 200200GTP-binding protein rho4PRO_0000198943Add
BLAST
Propeptidei201 – 2033Removed in mature formBy similarityPRO_0000281273

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei200 – 2001Cysteine methyl esterBy similarity
Lipidationi200 – 2001S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiQ874R1.

Interactioni

Protein-protein interaction databases

BioGridi280552. 17 interactions.
STRINGi4896.SPAC16A10.04-1.

Structurei

3D structure databases

ProteinModelPortaliQ874R1.
SMRiQ874R1. Positions 15-184.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 519Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233974.
InParanoidiQ874R1.
KOiK07975.
OMAiKESMRGR.
OrthoDBiEOG7SN8QP.
PhylomeDBiQ874R1.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00174. RHO. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q874R1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAFKKSGSK SETSKKLVVV GDGGCGKTCL LIVFSSGTFP ERYVPTVFEN
60 70 80 90 100
YITDITYGPN SKVIELALWD TAGQEEYDRL RPLSYPNSNV ILLCFSIDCP
110 120 130 140 150
ASLNNVTEKW YPEVQHFCPR TPIVLVGLKA DLRKDRNATE VLRTQGLTPV
160 170 180 190 200
TYQQAQSVAL SMNAPYVECS AKENTGVNEV FQLAVGLTIK KSFSFSKKSC

VIL
Length:203
Mass (Da):22,408
Last modified:January 16, 2004 - v2
Checksum:i69025B96208649F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAD86931.2.
RefSeqiNP_001018257.1. NM_001019469.2.

Genome annotation databases

EnsemblFungiiSPAC16A10.04.1; SPAC16A10.04.1:pep; SPAC16A10.04.
GeneIDi3361476.
KEGGispo:SPAC16A10.04.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAD86931.2 .
RefSeqi NP_001018257.1. NM_001019469.2.

3D structure databases

ProteinModelPortali Q874R1.
SMRi Q874R1. Positions 15-184.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 280552. 17 interactions.
STRINGi 4896.SPAC16A10.04-1.

Proteomic databases

MaxQBi Q874R1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC16A10.04.1 ; SPAC16A10.04.1:pep ; SPAC16A10.04 .
GeneIDi 3361476.
KEGGi spo:SPAC16A10.04.

Organism-specific databases

PomBasei SPAC16A10.04.

Phylogenomic databases

eggNOGi COG1100.
HOGENOMi HOG000233974.
InParanoidi Q874R1.
KOi K07975.
OMAi KESMRGR.
OrthoDBi EOG7SN8QP.
PhylomeDBi Q874R1.

Miscellaneous databases

NextBioi 20811519.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003578. Small_GTPase_Rho.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00174. RHO. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51420. RHO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel Rho GTPase involved in cytokinesis and cell wall integrity in the fission yeast Schizosaccharomyces pombe."
    Santos B., Gutierrez J., Calonge T.M., Perez P.
    Eukaryot. Cell 2:521-533(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF GLY-23 AND THR-28.
  2. "The small GTPase Rho4 is involved in controlling cell morphology and septation in fission yeast."
    Nakano K., Mutoh T., Arai R., Mabuchi I.
    Genes Cells 8:357-370(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF GLY-23 AND GLN-74.
  3. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiRHO4_SCHPO
AccessioniPrimary (citable) accession number: Q874R1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: October 29, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3