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Reviewed, UniProtKB/Swiss-Prot Q874I4 (PYRD_CANAL)

Last modified November 25, 2008. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Dihydroorotate dehydrogenase, mitochondrial
      Short name=DHOdehase
      Short name=DHODase
      Short name=DHOD
    EC=1.3.3.1
Alternative name(s):
    Dihydroorotate oxidase
Gene names
Name: URA9
OrganismCandida albicans (Yeast)
Taxonomic identifier5476 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length444 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

(S)-dihydroorotate + O(2) = orotate + H(2)O(2).

Cofactor

Binds 1 FAD per subunit By similarity.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 4/6.

Subcellular location

Mitochondrion inner membraneBy similarity.

Sequence similarities

Belongs to the dihydroorotate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 444Dihydroorotate dehydrogenase, mitochondrialPRO_0000029891

Sites

Active site2571Nucleophile By similarity

Sequences

Sequence LengthMass (Da)Tools
Q874I4-1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: CD37C62FFA2E6902

FASTA44448,426
        10         20         30         40         50         60 
MFRPSIKFKQ STLSIIARRL KSSAQHQPLR SSFVPSPIVF VAGLAVAAVG GYYCLDSRSA 

        70         80         90        100        110        120 
IHEYVLCPLI RTFTDAESGH KLGIFFMKYG LSPRLLDDGK NDQSDVLGVQ VFGHKLKNPI 

       130        140        150        160        170        180 
GLAAGLDKDG EAIESLFNCG FSYVEIGSIT PEPQPGNPQP RFFRLPKDDA VINRYGFNSS 

       190        200        210        220        230        240 
GHFNVLATLK LRFNKLLNKF GTSHSSEQHP FSNAFQQGKL LGINLGKNKF GDEVNDYVKG 

       250        260        270        280        290        300 
VERLGPYADV LVINVSSPNT PGLRDLQSEA KLTNLLTTVV KERNVLGKNL LGNKPPVLVK 

       310        320        330        340        350        360 
VAPDLTEPEI ESIANSAKEA KVDGIIISNT TIQRPVDRLL TTDKQLINQA GGLSGKPLKP 

       370        380        390        400        410        420 
LSLKALRTLR KYTKDSDLVL IGCGGISNGK DALEFGKAGA TFIELYTAFA YKGPGLVGKI 

       430        440 
RDELAEELRK EGKTWEQIIG SDDK 

« Hide

References

[1]"Horizontal gene transfer promoted evolution of the ability to propagate under anaerobic conditions in yeasts."
Gojkovic Z., Knecht W., Zameitat E., Warneboldt J., Coutelis J.B., Pynyaha Y., Neuveglise C., Moller K., Loffler M., Piskur J.
Mol. Genet. Genomics 271:387-393(2004) [PubMed: 15014982] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Candida albicans DHOD."
Hall C.R., Dietrich F.S.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: MMRL 2010.

Cross-references

Sequence databases

AY230865 Genomic DNA. Translation: AAO74621.1.
AY240959 Genomic DNA. Translation: AAP39962.1.

3D structure databases

HSSPHSSP built from PDB template 1D3G based on UniProtKB Q02127.
ModBaseSearch...

Organism-specific databases

CGDCAL0005359. URA1.

Family and domain databases

InterProIPR013785. Aldolase_TIM.
IPR005719. DHO_DHase_2.
IPR001295. Dihydroorotate_DHase_core.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PfamPF01180. DHO_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR01036. pyrD_sub2. 1 hit.
PROSITEPS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRD_CANAL
AccessionPrimary (citable) accession number: Q874I4
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2003
Last modified: November 25, 2008
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

Candida albicans

Candida albicans: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents