Reviewed, UniProtKB/Swiss-Prot Q874B3 (MTLD_PARBR)

Names and origin

Protein names	Recommended name:     Mannitol-1-phosphate 5-dehydrogenase       Short name=M1PDH       Short name=MPDH       Short name=MPD     EC=1.1.1.17
Organism	Paracoccidioides brasiliensis
Taxonomic identifier	121759 [NCBI]
Taxonomic lineage	Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Onygenales › mitosporic Onygenales › Paracoccidioides

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the NAD(H)-dependent interconversion of D-fructose 6-phosphate and D-mannitol 1-phosphate in the mannitol metabolic pathway By similarity.
Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 388	388	Mannitol-1-phosphate 5-dehydrogenase		PRO_0000371531
Regions
	Nucleotide binding	5 – 16	12	NAD By similarity
Sites
	Active site	213	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q874B3-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: B783BA0D44AF4FBC	FASTA	388	43,032
	10 20 30 40 50 60 MGKKAVHFGG GNIGRGFVGE FLHESGYEVV FVDVMDSVID ALQKASSYTV TEISGEGEHK 70 80 90 100 110 120 KVIENYRAIN SKHNLDDVIK EISTADVVTC AVGPNILKFI APPIAKGIDI RTQPKPLAVI 130 140 150 160 170 180 ACENAIGATD TLHGFIKDNT DESRRDSLPS RAQFANSAID RIVPTQDPNS GLDVKIEKFY 190 200 210 220 230 240 EWVVEKTPFG DVGHPDIKAI HWVDNLEPYI ERKLFTVNTG HATAAYFGYN AGKPTIHDAL 250 260 270 280 290 300 KDERIRSQVN AVLAETSALI VEKHHIPAEE QHDYVQKIIT RISNPYLEDV VQRVGRAPLR 310 320 330 340 350 360 KLSRKERFIG PAAQLAERGQ QVDALMGAVE EALKFQNVPD DEESFELHKI LKELSAADAT 370 380 TKLTDLEPDH PLYPRVLEKV TKVQSETK

References

[1]	"The mannitol-1-phosphate dehydrogenase of Paracoccidioides brasiliensis." Castro N.S., Parente J.A., Jesuino R.S.A., Pereira M., Felipe M.S.S., Soares C.M.A. Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY204753 mRNA. Translation: AAO47089.1.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR000669. Mannitol_DH_core. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_PARBR

Accession

Primary (citable) accession number: Q874B3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
Last sequence update:	June 1, 2003
Last modified:	June 16, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)