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Protein

Glutathione reductase

Gene

gtr-1

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Maintains high levels of reduced glutathione in the cytosol.By similarity

Miscellaneous

The active site is a redox-active disulfide bond.By similarity

Catalytic activityi

2 glutathione + NADP+ = glutathione disulfide + NADPH.

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei457Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi38 – 46FADBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione reductase (EC:1.8.1.7)
Short name:
GR
Short name:
GRase
Gene namesi
Name:gtr-1
Synonyms:glr1
ORF Names:B10C3.130, NCU03339
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 6, Linkage Group II

Organism-specific databases

EuPathDBiFungiDB:NCU03339

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000679691 – 468Glutathione reductaseAdd BLAST468

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 51Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ873E8

Structurei

3D structure databases

ProteinModelPortaliQ873E8
SMRiQ873E8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

HOGENOMiHOG000276712
InParanoidiQ873E8
KOiK00383
OMAiVYGLHYL
OrthoDBiEOG092C2ILO

Family and domain databases

Gene3Di3.30.390.30, 1 hit
3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
IPR006322 Glutathione_Rdtase_euk/bac
IPR001100 Pyr_nuc-diS_OxRdtase
IPR004099 Pyr_nucl-diS_OxRdtase_dimer
IPR012999 Pyr_OxRdtase_I_AS
PANTHERiPTHR42737 PTHR42737, 1 hit
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PF02852 Pyr_redox_dim, 1 hit
PIRSFiPIRSF000350 Mercury_reductase_MerA, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
SSF55424 SSF55424, 1 hit
TIGRFAMsiTIGR01421 gluta_reduc_1, 1 hit
PROSITEiView protein in PROSITE
PS00076 PYRIDINE_REDOX_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q873E8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPISRETDF LVIGGGSGGI ATARAAAGKY GIKSMVVEGK RLGGTCVNVG
60 70 80 90 100
CVPKKVTFYA ALVAETIHQA KDYGFSVEQT APFDWPTFKQ KRDAYVARLN
110 120 130 140 150
GIYERNLAND KVEYVHGWAK LLSPNSVEVT LDDGTKSVVN AKKILIAVGG
160 170 180 190 200
NPTIPPHIPG SEYGTNSDGF FDIDTLPKKV ALVGAGYIAV EFAGMLNALG
210 220 230 240 250
VETHLFIRHD TFLRSFDPMI QQVSVKEYER IGVKVHKKSQ LTSVQKDAAG
260 270 280 290 300
KLAINFKEGE GEQSISDVDH LIWAVGRTPA VEGLGLDKAG VKTNEKGYIE
310 320 330 340 350
VDEYQNTSTE NIYAVGDVCG QVELTPVAIA AGRKLAARLF GPEEFRTLKL
360 370 380 390 400
NYDNVPSVVF AHPEIGSIGL TEPEAVAKYG AENLKIYKSS FTAMYYAMMK
410 420 430 440 450
PEDKAPTAYK LICAGPEEKV VGLHIIGLGS GEILQGFGVA VNMGATKADF
460
DNCVAIHPTS AEELVTLK
Length:468
Mass (Da):50,313
Last modified:June 1, 2003 - v1
Checksum:iA3802C1A7DC0B479
GO

Sequence cautioni

The sequence ESA43520 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence ESA43521 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284749 Genomic DNA Translation: CAD70360.1
CM002237 Genomic DNA Translation: ESA43520.1 Different initiation.
CM002237 Genomic DNA Translation: ESA43521.1 Different initiation.
RefSeqiXP_011393526.1, XM_011395224.1
XP_011393527.1, XM_011395225.1

Genome annotation databases

EnsemblFungiiESA43520; ESA43520; NCU03339
ESA43521; ESA43521; NCU03339
GeneIDi3872613
KEGGincr:NCU03339

Similar proteinsi

Entry informationi

Entry nameiGSHR_NEUCR
AccessioniPrimary (citable) accession number: Q873E8
Secondary accession number(s): Q1K529, V5IP83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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