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Q872S3

- OS9_NEUCR

UniProt

Q872S3 - OS9_NEUCR

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Protein

Protein OS-9 homolog

Gene

yos-9

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei189 – 1891CarbohydrateBy similarity
Binding sitei266 – 2661CarbohydrateBy similarity
Binding sitei272 – 2721CarbohydrateBy similarity
Binding sitei294 – 2941CarbohydrateBy similarity
Binding sitei300 – 3001CarbohydrateBy similarity

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Protein OS-9 homolog
Gene namesi
Name:yos-9
ORF Names:B13B3.010, NCU08445
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
ProteomesiUP000001805: Chromosome 6, Linkage Group II

Subcellular locationi

Endoplasmic reticulum membrane PROSITE-ProRule annotation; Peripheral membrane protein By similarity; Lumenal side By similarity

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 590571Protein OS-9 homologPRO_0000043273Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi136 – 1361N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi169 ↔ 182By similarity
Disulfide bondi265 ↔ 298By similarity
Disulfide bondi280 ↔ 310By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Interacts with missfolded ER lumenal proteins.By similarity

Protein-protein interaction databases

STRINGi5141.NCU08445.1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini167 – 25084PRKCSHAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi587 – 5904Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the OS-9 family.Curated
Contains 1 PRKCSH domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG309879.
InParanoidiQ872S3.
KOiK10088.
OMAiNLNDERE.
OrthoDBiEOG7R2BVR.

Family and domain databases

InterProiIPR009011. Man6P_isomerase_rcpt-bd_dom.
IPR012913. PRKCSH.
[Graphical view]
PfamiPF07915. PRKCSH. 1 hit.
[Graphical view]
SUPFAMiSSF50911. SSF50911. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q872S3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRRPSLALLA LSSLPFGSAR QPASFSIHQD LLAHPQFEVI FSDSYVFEAD
60 70 80 90 100
AFALLEAANK TPKPTPASDG AHDGSTTRTD LTSAIRESAT ANADTDNGDE
110 120 130 140 150
SIGGTSPLRE TYELIAHPPM RYLCSIPIIA PPPALNKTAT ELAKAEEARE
160 170 180 190 200
VTRAYNKGWE LMRGLENQCL HFVSGWWSYQ YCYGKSIVQY HAVPNPKGGP
210 220 230 240 250
PLRDKNSQEY ILGTSLPPSS HSQKGKQIEV PNNEQKQLSP PPNTELQAKD
260 270 280 290 300
NQRYLVQRLD GGTICDLTGR PRTIEIQYHC NPALSGDRIG WIKEVTTCAY
310 320 330 340 350
LMVIHTPRLC ADVAFLPPKE TKAHPITCRQ IITSDEEALS FNQRRKNTID
360 370 380 390 400
SAAAAAAAVT TEDQKQGSES GSPEKLSYQG LTVAGIPIGA RRILPSTHVL
410 420 430 440 450
PLPRHLQQQR QEAQQGNLLE ALTKAAFKAD VFGDYGDDNN NNNNNHHPKA
460 470 480 490 500
GKGRKAAGAG KGQSGQKEMK KMRISERDID KLGLDQQTLD ALREEIRAAG
510 520 530 540 550
LDPDRNLNDE REAGGEIVWE FYADVSGDED DGAVAEEGKE VFVWYEDEDE
560 570 580 590
GGEPAEAGKD QKESKKGGNG EGSGSGSEEG SKEEYYRDEL
Length:590
Mass (Da):64,567
Last modified:June 1, 2003 - v1
Checksum:i7F1D509692ACF72D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX284762 Genomic DNA. Translation: CAD70506.1.
CM002237 Genomic DNA. Translation: EAA34179.1.
RefSeqiXP_963415.1. XM_958322.1.
UniGeneiNcr.20262.

Genome annotation databases

EnsemblFungiiEFNCRT00000007822; EFNCRP00000007811; EFNCRG00000007810.
GeneIDi3879555.
KEGGincr:NCU08445.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX284762 Genomic DNA. Translation: CAD70506.1 .
CM002237 Genomic DNA. Translation: EAA34179.1 .
RefSeqi XP_963415.1. XM_958322.1.
UniGenei Ncr.20262.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5141.NCU08445.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii EFNCRT00000007822 ; EFNCRP00000007811 ; EFNCRG00000007810 .
GeneIDi 3879555.
KEGGi ncr:NCU08445.

Phylogenomic databases

eggNOGi NOG309879.
InParanoidi Q872S3.
KOi K10088.
OMAi NLNDERE.
OrthoDBi EOG7R2BVR.

Family and domain databases

InterProi IPR009011. Man6P_isomerase_rcpt-bd_dom.
IPR012913. PRKCSH.
[Graphical view ]
Pfami PF07915. PRKCSH. 1 hit.
[Graphical view ]
SUPFAMi SSF50911. SSF50911. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
    Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
    Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
  2. "The genome sequence of the filamentous fungus Neurospora crassa."
    Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
    , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
    Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Entry informationi

Entry nameiOS9_NEUCR
AccessioniPrimary (citable) accession number: Q872S3
Secondary accession number(s): Q1K8N3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3