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Q872S3

- OS9_NEUCR

UniProt

Q872S3 - OS9_NEUCR

Protein

Protein OS-9 homolog

Gene

yos-9

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei189 – 1891CarbohydrateBy similarity
    Binding sitei266 – 2661CarbohydrateBy similarity
    Binding sitei272 – 2721CarbohydrateBy similarity
    Binding sitei294 – 2941CarbohydrateBy similarity
    Binding sitei300 – 3001CarbohydrateBy similarity

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein OS-9 homolog
    Gene namesi
    Name:yos-9
    ORF Names:B13B3.010, NCU08445
    OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
    Taxonomic identifieri367110 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
    ProteomesiUP000001805: Chromosome 6, Linkage Group II

    Subcellular locationi

    Endoplasmic reticulum membrane PROSITE-ProRule annotation; Peripheral membrane protein By similarity; Lumenal side By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 590571Protein OS-9 homologPRO_0000043273Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi136 – 1361N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi169 ↔ 182By similarity
    Disulfide bondi265 ↔ 298By similarity
    Disulfide bondi280 ↔ 310By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Interacts with missfolded ER lumenal proteins.By similarity

    Protein-protein interaction databases

    STRINGi5141.NCU08445.1.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini167 – 25084PRKCSHAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi587 – 5904Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the OS-9 family.Curated
    Contains 1 PRKCSH domain.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG309879.
    KOiK10088.
    OMAiNLNDERE.
    OrthoDBiEOG7R2BVR.

    Family and domain databases

    InterProiIPR009011. Man6P_isomerase_rcpt-bd_dom.
    IPR012913. PRKCSH.
    [Graphical view]
    PfamiPF07915. PRKCSH. 1 hit.
    [Graphical view]
    SUPFAMiSSF50911. SSF50911. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q872S3-1 [UniParc]FASTAAdd to Basket

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    MRRPSLALLA LSSLPFGSAR QPASFSIHQD LLAHPQFEVI FSDSYVFEAD    50
    AFALLEAANK TPKPTPASDG AHDGSTTRTD LTSAIRESAT ANADTDNGDE 100
    SIGGTSPLRE TYELIAHPPM RYLCSIPIIA PPPALNKTAT ELAKAEEARE 150
    VTRAYNKGWE LMRGLENQCL HFVSGWWSYQ YCYGKSIVQY HAVPNPKGGP 200
    PLRDKNSQEY ILGTSLPPSS HSQKGKQIEV PNNEQKQLSP PPNTELQAKD 250
    NQRYLVQRLD GGTICDLTGR PRTIEIQYHC NPALSGDRIG WIKEVTTCAY 300
    LMVIHTPRLC ADVAFLPPKE TKAHPITCRQ IITSDEEALS FNQRRKNTID 350
    SAAAAAAAVT TEDQKQGSES GSPEKLSYQG LTVAGIPIGA RRILPSTHVL 400
    PLPRHLQQQR QEAQQGNLLE ALTKAAFKAD VFGDYGDDNN NNNNNHHPKA 450
    GKGRKAAGAG KGQSGQKEMK KMRISERDID KLGLDQQTLD ALREEIRAAG 500
    LDPDRNLNDE REAGGEIVWE FYADVSGDED DGAVAEEGKE VFVWYEDEDE 550
    GGEPAEAGKD QKESKKGGNG EGSGSGSEEG SKEEYYRDEL 590
    Length:590
    Mass (Da):64,567
    Last modified:June 1, 2003 - v1
    Checksum:i7F1D509692ACF72D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX284762 Genomic DNA. Translation: CAD70506.1.
    CM002237 Genomic DNA. Translation: EAA34179.1.
    RefSeqiXP_963415.1. XM_958322.1.
    UniGeneiNcr.20262.

    Genome annotation databases

    EnsemblFungiiEFNCRT00000007822; EFNCRP00000007811; EFNCRG00000007810.
    GeneIDi3879555.
    KEGGincr:NCU08445.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX284762 Genomic DNA. Translation: CAD70506.1 .
    CM002237 Genomic DNA. Translation: EAA34179.1 .
    RefSeqi XP_963415.1. XM_958322.1.
    UniGenei Ncr.20262.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5141.NCU08445.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFNCRT00000007822 ; EFNCRP00000007811 ; EFNCRG00000007810 .
    GeneIDi 3879555.
    KEGGi ncr:NCU08445.

    Phylogenomic databases

    eggNOGi NOG309879.
    KOi K10088.
    OMAi NLNDERE.
    OrthoDBi EOG7R2BVR.

    Family and domain databases

    InterProi IPR009011. Man6P_isomerase_rcpt-bd_dom.
    IPR012913. PRKCSH.
    [Graphical view ]
    Pfami PF07915. PRKCSH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50911. SSF50911. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
      Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
      Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
    2. "The genome sequence of the filamentous fungus Neurospora crassa."
      Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
      , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
      Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

    Entry informationi

    Entry nameiOS9_NEUCR
    AccessioniPrimary (citable) accession number: Q872S3
    Secondary accession number(s): Q1K8N3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3