Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q872S3 (OS9_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein OS-9 homolog
Gene names
Name:yos-9
ORF Names:B13B3.010, NCU08445
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Sordariales › Sordariaceae › Neurospora ›

Protein attributes

Sequence length590 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation By similarity.

Subunit structure

Interacts with missfolded ER lumenal proteins By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side By similarity.

Sequence similarities

Belongs to the OS-9 family.

Contains 1 PRKCSH domain.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
   DomainSignal
   LigandLectin
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 590571Protein OS-9 homolog
PRO_0000043273

Regions

Domain167 – 25084PRKCSH
Motif587 – 5904Prevents secretion from ER Potential

Sites

Binding site1891Carbohydrate By similarity
Binding site2661Carbohydrate By similarity
Binding site2721Carbohydrate By similarity
Binding site2941Carbohydrate By similarity
Binding site3001Carbohydrate By similarity

Amino acid modifications

Glycosylation1361N-linked (GlcNAc...) Potential
Disulfide bond169 ↔ 182 By similarity
Disulfide bond265 ↔ 298 By similarity
Disulfide bond280 ↔ 310 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q872S3 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 7F1D509692ACF72D

FASTA59064,567
        10         20         30         40         50         60 
MRRPSLALLA LSSLPFGSAR QPASFSIHQD LLAHPQFEVI FSDSYVFEAD AFALLEAANK 

        70         80         90        100        110        120 
TPKPTPASDG AHDGSTTRTD LTSAIRESAT ANADTDNGDE SIGGTSPLRE TYELIAHPPM 

       130        140        150        160        170        180 
RYLCSIPIIA PPPALNKTAT ELAKAEEARE VTRAYNKGWE LMRGLENQCL HFVSGWWSYQ 

       190        200        210        220        230        240 
YCYGKSIVQY HAVPNPKGGP PLRDKNSQEY ILGTSLPPSS HSQKGKQIEV PNNEQKQLSP 

       250        260        270        280        290        300 
PPNTELQAKD NQRYLVQRLD GGTICDLTGR PRTIEIQYHC NPALSGDRIG WIKEVTTCAY 

       310        320        330        340        350        360 
LMVIHTPRLC ADVAFLPPKE TKAHPITCRQ IITSDEEALS FNQRRKNTID SAAAAAAAVT 

       370        380        390        400        410        420 
TEDQKQGSES GSPEKLSYQG LTVAGIPIGA RRILPSTHVL PLPRHLQQQR QEAQQGNLLE 

       430        440        450        460        470        480 
ALTKAAFKAD VFGDYGDDNN NNNNNHHPKA GKGRKAAGAG KGQSGQKEMK KMRISERDID 

       490        500        510        520        530        540 
KLGLDQQTLD ALREEIRAAG LDPDRNLNDE REAGGEIVWE FYADVSGDED DGAVAEEGKE 

       550        560        570        580        590 
VFVWYEDEDE GGEPAEAGKD QKESKKGGNG EGSGSGSEEG SKEEYYRDEL

« Hide

References

[1]"What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[2]"The genome sequence of the filamentous fungus Neurospora crassa."
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. expand/collapse author list , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX284762 Genomic DNA. Translation: CAD70506.1.
AABX02000044 Genomic DNA. Translation: EAA34179.1.
RefSeqXP_963415.1. XM_958322.1.
UniGeneNcr.20262.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000007822; EFNCRP00000007811; EFNCRG00000007810.
GeneID3879555.
KEGGncr:NCU08445.

Phylogenomic databases

eggNOGNOG309879.
KOK10088.
OMAPRTIEIQ.
OrthoDBEOG4PCF2J.

Family and domain databases

InterProIPR009011. Man6P_isomerase_rcpt-bd_dom.
IPR012913. PRKCSH.
[Graphical view]
PfamPF07915. PRKCSH. 1 hit.
[Graphical view]
SUPFAMSSF50911. Man6php_recept. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOS9_NEUCR
AccessionPrimary (citable) accession number: Q872S3
Secondary accession number(s): Q1K8N3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2003
Last modified: April 3, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents