ID   Q872Q1_NEUCS            Unreviewed;       293 AA.
AC   Q872Q1;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   27-MAR-2024, entry version 102.
DE   RecName: Full=Cellulase {ECO:0000256|ARBA:ARBA00012601, ECO:0000256|PROSITE-ProRule:PRU10069};
DE            EC=3.2.1.4 {ECO:0000256|ARBA:ARBA00012601, ECO:0000256|PROSITE-ProRule:PRU10069};
GN   Name=B19A17.010 {ECO:0000313|EMBL:CAD70529.1};
GN   ORFNames=GE21DRAFT_9486 {ECO:0000313|EMBL:KHE87990.1};
OS   Neurospora crassa.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=5141 {ECO:0000313|EMBL:CAD70529.1};
RN   [1] {ECO:0000313|EMBL:CAD70529.1}
RP   NUCLEOTIDE SEQUENCE.
RA   German Neurospora genome project;
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CAD70529.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Schulte U., Aign V., Hoheisel J., Brandt P., Fartmann B., Holland R.,
RA   Nyakatura G., Mewes H.W., Mannhaupt G.;
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:KHE87990.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=73 {ECO:0000313|EMBL:KHE87990.1};
RG   DOE Joint Genome Institute;
RA   Baker S.E., Grigoriev I., Haridas S., LaButti K., McCluskey K.;
RT   "Draft genome sequence of Neurospora crassa strain FGSC 73.";
RL   Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endohydrolysis of (1->4)-beta-D-glucosidic linkages in
CC         cellulose, lichenin and cereal beta-D-glucans.; EC=3.2.1.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00000966, ECO:0000256|PROSITE-
CC         ProRule:PRU10069};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 45 (cellulase K) family.
CC       {ECO:0000256|ARBA:ARBA00007793}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX284763; CAD70529.1; -; Genomic_DNA.
DR   EMBL; KN389638; KHE87990.1; -; Genomic_DNA.
DR   SMR; Q872Q1; -.
DR   CAZy; CBM1; Carbohydrate-Binding Module Family 1.
DR   CAZy; GH45; Glycoside Hydrolase Family 45.
DR   VEuPathDB; FungiDB:NCU05121; -.
DR   eggNOG; ENOG502RXA6; Eukaryota.
DR   HOGENOM; CLU_045022_1_0_1; -.
DR   OrthoDB; 1349031at2759; -.
DR   Proteomes; UP000053122; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0008810; F:cellulase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030248; F:cellulose binding; IEA:InterPro.
DR   GO; GO:0030245; P:cellulose catabolic process; IEA:UniProtKB-KW.
DR   CDD; cd22278; DPBB_GH45_endoglucanase; 1.
DR   Gene3D; 2.40.40.10; RlpA-like domain; 1.
DR   InterPro; IPR035971; CBD_sf.
DR   InterPro; IPR000254; Cellulose-bd_dom_fun.
DR   InterPro; IPR000334; Glyco_hydro_45.
DR   InterPro; IPR036908; RlpA-like_sf.
DR   PANTHER; PTHR39730; ENDOGLUCANASE 1; 1.
DR   PANTHER; PTHR39730:SF1; ENDOGLUCANASE 1; 1.
DR   Pfam; PF00734; CBM_1; 1.
DR   Pfam; PF02015; Glyco_hydro_45; 1.
DR   SMART; SM00236; fCBD; 1.
DR   SUPFAM; SSF50685; Barwin-like endoglucanases; 1.
DR   SUPFAM; SSF57180; Cellulose-binding domain; 1.
DR   PROSITE; PS00562; CBM1_1; 1.
DR   PROSITE; PS51164; CBM1_2; 1.
DR   PROSITE; PS01140; GLYCOSYL_HYDROL_F45; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW   Cellulose degradation {ECO:0000256|ARBA:ARBA00023001};
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Polysaccharide degradation {ECO:0000256|ARBA:ARBA00023326};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..293
FT                   /note="Cellulase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5010846870"
FT   DOMAIN          257..293
FT                   /note="CBM1"
FT                   /evidence="ECO:0000259|PROSITE:PS51164"
FT   REGION          221..255
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        221..254
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        33
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10069"
SQ   SEQUENCE   293 AA;  30261 MW;  E7D96407F349877A CRC64;
     MRSSTILQTG LVAALPFAVQ AASGSGQSTR YWDCCKPSCS WSGKAPVNRP VLACDANNNP
     LSDASVKSGC DGGSAYTCAN NSPWAVNDQL SYGFAATKLS GGTESSWCCA CYALTFTSGP
     VAGKTLVVQS TSTGGDLGSN HFDINMPGGG VGLFDGCKRQ FGGLPGAQYG GISSRSQCDS
     FPAALKPGCQ WRFDWFQNAD NPNFTFKQVQ CPSELTSRTG CKRNDDSQFP VFTPPSGGGS
     NPSTPTTPPS SGGGSGCTAD KYAQCGGSGW SGCTNCPSGS TCKTINDYYH QCA
//